YMR315W

Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR315W / YMR315W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.29|P-value:5.73E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.65|P-value:1.52E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.44|P-value:3.06E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:5.42|P-value:3.95E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:6.39|P-value:1.16E-10 ID:SGTC_202|Compound:3594-0513|FD-Score:3.34|P-value:4.80E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:6.37|P-value:1.34E-10 ID:SGTC_211|Compound:3455-0679|FD-Score:4.03|P-value:3.25E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.77|P-value:9.52E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.39|P-value:4.03E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.99|P-value:2.10E-12 ID:SGTC_667|Compound:1498-1044|FD-Score:3.40|P-value:3.86E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.20|P-value:7.05E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:6.13|P-value:6.02E-10 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.23|P-value:7.01E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.70|P-value:1.12E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.45|P-value:2.92E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.20|P-value:1.61E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.66|P-value:1.43E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.93|P-value:5.02E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.96|P-value:4.32E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.13|P-value:9.64E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.17|P-value:8.46E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.36|P-value:7.69E-6 ID:SGTC_1739|Compound:st037196|FD-Score:5.07|P-value:2.48E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-3.12|P-value:9.32E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.11|P-value:9.68E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.95|P-value:4.08E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.21|P-value:7.51E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.88|P-value:6.02E-5 ID:SGTC_2286|Compound:7945697|FD-Score:4.33|P-value:9.08E-6 ID:SGTC_2357|Compound:9067248|FD-Score:4.45|P-value:5.13E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.48|P-value:4.54E-6 ID:SGTC_2459|Compound:5811157|FD-Score:3.34|P-value:4.67E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.48|P-value:2.88E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.32|P-value:9.22E-6 ID:SGTC_2556|Compound:citropten|FD-Score:-3.16|P-value:8.10E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.45|P-value:5.17E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.90|P-value:5.71E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.14|P-value:1.75E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.26|P-value:6.20E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.45|P-value:3.21E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.48|P-value:2.61E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.93|P-value:5.27E-7 ID:SGTC_3242|Compound:9133940|FD-Score:3.34|P-value:4.79E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.29|P-value:5.73E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.65|P-value:1.52E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.44|P-value:3.06E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:5.42|P-value:3.95E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:6.39|P-value:1.16E-10 ID:SGTC_202|Compound:3594-0513|FD-Score:3.34|P-value:4.80E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:6.37|P-value:1.34E-10 ID:SGTC_211|Compound:3455-0679|FD-Score:4.03|P-value:3.25E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.77|P-value:9.52E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.39|P-value:4.03E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.99|P-value:2.10E-12 ID:SGTC_667|Compound:1498-1044|FD-Score:3.40|P-value:3.86E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.20|P-value:7.05E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:6.13|P-value:6.02E-10 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.23|P-value:7.01E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.70|P-value:1.12E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.45|P-value:2.92E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.20|P-value:1.61E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.66|P-value:1.43E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.93|P-value:5.02E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.96|P-value:4.32E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.13|P-value:9.64E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.17|P-value:8.46E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.36|P-value:7.69E-6 ID:SGTC_1739|Compound:st037196|FD-Score:5.07|P-value:2.48E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-3.12|P-value:9.32E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.11|P-value:9.68E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.95|P-value:4.08E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.21|P-value:7.51E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.88|P-value:6.02E-5 ID:SGTC_2286|Compound:7945697|FD-Score:4.33|P-value:9.08E-6 ID:SGTC_2357|Compound:9067248|FD-Score:4.45|P-value:5.13E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.48|P-value:4.54E-6 ID:SGTC_2459|Compound:5811157|FD-Score:3.34|P-value:4.67E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.48|P-value:2.88E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.32|P-value:9.22E-6 ID:SGTC_2556|Compound:citropten|FD-Score:-3.16|P-value:8.10E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.45|P-value:5.17E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.90|P-value:5.71E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.14|P-value:1.75E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.26|P-value:6.20E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.45|P-value:3.21E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.48|P-value:2.61E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.93|P-value:5.27E-7 ID:SGTC_3242|Compound:9133940|FD-Score:3.34|P-value:4.79E-4

Top fitness defect scores for YMR315W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 6.99 121.0 µM 2.10E-12 translation 22 1.39E-12
2 SGTC_161 4065-0411 6.39 162.2 µM 1.16E-10 22 8.19E-11
3 SGTC_204 1543-0184 6.37 62.4 µM 1.34E-10 TRP & mitochondrial translation 8 9.42E-11
4 SGTC_968 1309-0633 6.13 340.0 µM 6.02E-10 2 4.34E-10
5 SGTC_121 0557-0495 5.42 61.3 µM 3.95E-8 calcium & mitochondrial duress 22 3.03E-8
6 SGTC_2658 polymyxin b sulfate 5.14 77.0 µM 1.75E-7 NEO1 28 1.38E-7
7 SGTC_1739 st037196 5.07 92.5 µM 2.48E-7 4 1.95E-7
8 SGTC_3231 9132313 4.93 49.5 µM 5.27E-7 1 4.20E-7
9 SGTC_2368 9071271 4.48 200.0 µM 4.54E-6 21 3.74E-6
10 SGTC_2357 9067248 4.45 200.0 µM 5.13E-6 9 4.23E-6
11 SGTC_2607 solasodine 4.45 47.4 µM 5.17E-6 43 4.27E-6
12 SGTC_1713 st033146 4.36 12.8 µM 7.69E-6 18 6.38E-6
13 SGTC_2286 7945697 4.33 125.0 µM 9.08E-6 42 7.55E-6
14 SGTC_2549 cedrol 4.32 20.9 µM 9.22E-6 11 7.67E-6
15 SGTC_1124 fisetin 4.20 1.2 µM 1.61E-5 27 1.35E-5
16 SGTC_211 3455-0679 4.03 143.5 µM 3.25E-5 17 2.75E-5
17 SGTC_1205 4161-2785 3.96 76.0 µM 4.32E-5 31 3.68E-5
18 SGTC_1197 1601-0112 3.93 267.0 µM 5.02E-5 19 4.29E-5
19 SGTC_2613 3',4'-dimethoxydalbergione 3.90 24.6 µM 5.71E-5 26 4.88E-5
20 SGTC_2285 7945142 3.88 200.0 µM 6.02E-5 24 5.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.34E-12 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.116 1.36E-11 YML055W SPC2 hom Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
0.114 4.33E-11 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.107 5.40E-10 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.103 2.03E-9 YMR082C_d YMR082C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.21E-9 YML010W SPT5 het Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.090 2.12E-7 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.088 3.23E-7 YHL021C AIM17 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.087 4.86E-7 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.084 1.24E-6 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.083 1.66E-6 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit
0.082 1.73E-6 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.082 1.79E-6 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.082 2.05E-6 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.079 4.44E-6 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss