YMR316C-A_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR316C-A / YMR316C-A

Click on Significant Values for Screen Details ID:SGTC_173|Compound:1273-0061|FD-Score:4.20|P-value:6.92E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.14|P-value:5.74E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.41|P-value:1.83E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.00|P-value:9.51E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.41|P-value:2.04E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.43|P-value:1.89E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.43|P-value:9.20E-9 ID:SGTC_784|Compound:4579-0127|FD-Score:3.35|P-value:2.64E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.33|P-value:2.79E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.53|P-value:1.28E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:4.95|P-value:1.47E-7 ID:SGTC_921|Compound:1561-0023|FD-Score:5.16|P-value:4.36E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:3.00|P-value:9.56E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.80|P-value:4.25E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.03|P-value:8.49E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.64|P-value:8.04E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.23|P-value:3.71E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.98|P-value:1.91E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.19|P-value:4.74E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.91|P-value:2.53E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-4.21|P-value:5.61E-6 ID:SGTC_1790|Compound:st045711|FD-Score:5.10|P-value:6.05E-8 ID:SGTC_1794|Compound:st048918|FD-Score:3.97|P-value:1.95E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.34|P-value:2.77E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.73|P-value:5.55E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.08|P-value:7.19E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.30|P-value:2.88E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.60|P-value:9.25E-7 ID:SGTC_1861|Compound:st057647|FD-Score:3.20|P-value:4.66E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.30|P-value:3.22E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.19|P-value:4.34E-4 ID:SGTC_2029|Compound:5175081|FD-Score:5.18|P-value:3.98E-8 ID:SGTC_2061|Compound:5245884|FD-Score:3.35|P-value:2.64E-4 ID:SGTC_2075|Compound:5212009|FD-Score:5.04|P-value:8.76E-8 ID:SGTC_2191|Compound:5911152|FD-Score:3.53|P-value:1.29E-4 ID:SGTC_2281|Compound:7943571|FD-Score:6.75|P-value:1.22E-12 ID:SGTC_2288|Compound:7946289|FD-Score:3.74|P-value:5.43E-5 ID:SGTC_2450|Compound:5739737|FD-Score:4.38|P-value:2.87E-6 ID:SGTC_2453|Compound:5731132|FD-Score:-3.49|P-value:1.31E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.51|P-value:1.25E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.16|P-value:5.36E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.43|P-value:1.73E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.70|P-value:6.34E-5 ID:SGTC_2713|Compound:st079149|FD-Score:4.00|P-value:1.68E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.56|P-value:1.14E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.40|P-value:2.18E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.00|P-value:9.43E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.20|P-value:6.78E-6 ID:SGTC_2852|Compound:9023854|FD-Score:5.62|P-value:2.85E-9 ID:SGTC_3101|Compound:9120531|FD-Score:3.81|P-value:4.06E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.72|P-value:5.78E-5 ID:SGTC_3307|Compound:9126885|FD-Score:5.30|P-value:1.93E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:4.20|P-value:6.92E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.14|P-value:5.74E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.41|P-value:1.83E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.00|P-value:9.51E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.41|P-value:2.04E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.43|P-value:1.89E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.43|P-value:9.20E-9 ID:SGTC_784|Compound:4579-0127|FD-Score:3.35|P-value:2.64E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.33|P-value:2.79E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.53|P-value:1.28E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:4.95|P-value:1.47E-7 ID:SGTC_921|Compound:1561-0023|FD-Score:5.16|P-value:4.36E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:3.00|P-value:9.56E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.80|P-value:4.25E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.03|P-value:8.49E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.64|P-value:8.04E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.23|P-value:3.71E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.98|P-value:1.91E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.19|P-value:4.74E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.91|P-value:2.53E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-4.21|P-value:5.61E-6 ID:SGTC_1790|Compound:st045711|FD-Score:5.10|P-value:6.05E-8 ID:SGTC_1794|Compound:st048918|FD-Score:3.97|P-value:1.95E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.34|P-value:2.77E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.73|P-value:5.55E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.08|P-value:7.19E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.30|P-value:2.88E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.60|P-value:9.25E-7 ID:SGTC_1861|Compound:st057647|FD-Score:3.20|P-value:4.66E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.30|P-value:3.22E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.19|P-value:4.34E-4 ID:SGTC_2029|Compound:5175081|FD-Score:5.18|P-value:3.98E-8 ID:SGTC_2061|Compound:5245884|FD-Score:3.35|P-value:2.64E-4 ID:SGTC_2075|Compound:5212009|FD-Score:5.04|P-value:8.76E-8 ID:SGTC_2191|Compound:5911152|FD-Score:3.53|P-value:1.29E-4 ID:SGTC_2281|Compound:7943571|FD-Score:6.75|P-value:1.22E-12 ID:SGTC_2288|Compound:7946289|FD-Score:3.74|P-value:5.43E-5 ID:SGTC_2450|Compound:5739737|FD-Score:4.38|P-value:2.87E-6 ID:SGTC_2453|Compound:5731132|FD-Score:-3.49|P-value:1.31E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.51|P-value:1.25E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.16|P-value:5.36E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.43|P-value:1.73E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.70|P-value:6.34E-5 ID:SGTC_2713|Compound:st079149|FD-Score:4.00|P-value:1.68E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.56|P-value:1.14E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.40|P-value:2.18E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.00|P-value:9.43E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.20|P-value:6.78E-6 ID:SGTC_2852|Compound:9023854|FD-Score:5.62|P-value:2.85E-9 ID:SGTC_3101|Compound:9120531|FD-Score:3.81|P-value:4.06E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.72|P-value:5.78E-5 ID:SGTC_3307|Compound:9126885|FD-Score:5.30|P-value:1.93E-8

Top fitness defect scores for YMR316C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2281 7943571 6.75 200.0 µM 1.22E-12 1 7.19E-12
2 SGTC_2852 9023854 5.62 52.0 µM 2.85E-9 12 9.67E-9
3 SGTC_722 3534-0461 5.43 190.0 µM 9.20E-9 PDR1 12 2.87E-8
4 SGTC_3307 9126885 5.30 69.3 µM 1.93E-8 11 5.70E-8
5 SGTC_2029 5175081 5.18 200.0 µM 3.98E-8 4 1.12E-7
6 SGTC_921 1561-0023 5.16 372.0 µM 4.36E-8 5 1.22E-7
7 SGTC_1790 st045711 5.10 43.5 µM 6.05E-8 4 1.65E-7
8 SGTC_2075 5212009 5.04 200.0 µM 8.76E-8 3 2.33E-7
9 SGTC_893 0958-0369 4.95 48.9 µM 1.47E-7 13 3.77E-7
10 SGTC_1854 st056233 4.60 32.9 µM 9.25E-7 amide catabolism 10 2.09E-6
11 SGTC_2450 5739737 4.38 12.9 µM 2.87E-6 15 6.00E-6
12 SGTC_2844 9010103 4.20 26.0 µM 6.78E-6 26 1.33E-5
13 SGTC_173 1273-0061 4.20 2.7 µM 6.92E-6 mitochondrial stress 177 1.36E-5
14 SGTC_2713 st079149 4.00 53.4 µM 1.68E-5 17 3.11E-5
15 SGTC_1289 0976-0073 3.98 69.1 µM 1.91E-5 11 3.50E-5
16 SGTC_1794 st048918 3.97 76.9 µM 1.95E-5 11 3.57E-5
17 SGTC_1739 st037196 3.91 92.5 µM 2.53E-5 24 4.55E-5
18 SGTC_3101 9120531 3.81 49.5 µM 4.06E-5 37 7.07E-5
19 SGTC_995 3931-2021 3.80 34.6 µM 4.25E-5 RPP1 & pyrimidine depletion 27 7.38E-5
20 SGTC_2288 7946289 3.74 167.3 µM 5.43E-5 34 9.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 6.66E-7 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress
0.080 3.77E-6 YOR185C GSP2 hom GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress
0.074 1.79E-5 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.071 4.33E-5 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.070 5.59E-5 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.30E-5 YBR060C ORC2 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
0.066 1.38E-4 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.065 1.55E-4 YPR172W_p YPR172W_p hom Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication
0.065 1.63E-4 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.065 1.64E-4 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.063 2.73E-4 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.063 2.87E-4 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.063 2.88E-4 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.062 3.03E-4 YHL031C GOS1 hom v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
0.061 3.91E-4 YPL067C_p YPL067C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene