YMR316W / DIA1

Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR316W / DIA1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:12.50|P-value:5.46E-33 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.49|P-value:3.76E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.86|P-value:3.15E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.77|P-value:1.73E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.74|P-value:1.95E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.99|P-value:1.04E-6 ID:SGTC_199|Compound:4063-0024|FD-Score:3.29|P-value:9.10E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:4.11|P-value:4.74E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.69|P-value:4.06E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.61|P-value:3.04E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.03|P-value:6.40E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:3.98|P-value:7.84E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.32|P-value:8.26E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.57|P-value:3.48E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:6.22|P-value:1.57E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:4.36|P-value:1.67E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:4.96|P-value:1.17E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:4.03|P-value:6.40E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:7.27|P-value:2.16E-12 ID:SGTC_908|Compound:3448-7491|FD-Score:3.42|P-value:5.89E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.10|P-value:4.86E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.37|P-value:6.85E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.37|P-value:1.65E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.28|P-value:2.39E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.44|P-value:5.56E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.22|P-value:3.09E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.46|P-value:5.11E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.24|P-value:2.82E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.77|P-value:1.72E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.72|P-value:2.05E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.47|P-value:4.05E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.27|P-value:9.64E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.54|P-value:3.93E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.81|P-value:1.62E-8 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.98|P-value:6.34E-9 ID:SGTC_1683|Compound:st010134|FD-Score:5.19|P-value:4.00E-7 ID:SGTC_1696|Compound:st025591|FD-Score:3.56|P-value:3.63E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.36|P-value:1.71E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.64|P-value:2.76E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.06|P-value:4.68E-5 ID:SGTC_1851|Compound:st056236|FD-Score:4.16|P-value:3.81E-5 ID:SGTC_1942|Compound:st076330|FD-Score:5.97|P-value:6.48E-9 ID:SGTC_2085|Compound:5307070|FD-Score:3.46|P-value:5.20E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.39|P-value:6.48E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.63|P-value:2.32E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.38|P-value:5.56E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.96|P-value:6.87E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.82|P-value:1.76E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.00|P-value:9.70E-7 ID:SGTC_2836|Compound:9010338|FD-Score:-3.91|P-value:8.34E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-3.57|P-value:2.85E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.75|P-value:1.50E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.66|P-value:4.61E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.38|P-value:6.79E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.23|P-value:9.17E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.22|P-value:3.05E-5 ID:SGTC_3235|Compound:9132602|FD-Score:4.23|P-value:2.87E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.28|P-value:9.39E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.00|P-value:7.14E-5 ID:SGTC_3335|Compound:9143315|FD-Score:3.27|P-value:9.77E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.82|P-value:1.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.50|P-value:5.46E-33 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.49|P-value:3.76E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.86|P-value:3.15E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.77|P-value:1.73E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.74|P-value:1.95E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.99|P-value:1.04E-6 ID:SGTC_199|Compound:4063-0024|FD-Score:3.29|P-value:9.10E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:4.11|P-value:4.74E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.69|P-value:4.06E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.61|P-value:3.04E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.03|P-value:6.40E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:3.98|P-value:7.84E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.32|P-value:8.26E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.57|P-value:3.48E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:6.22|P-value:1.57E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:4.36|P-value:1.67E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:4.96|P-value:1.17E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:4.03|P-value:6.40E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:7.27|P-value:2.16E-12 ID:SGTC_908|Compound:3448-7491|FD-Score:3.42|P-value:5.89E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.10|P-value:4.86E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.37|P-value:6.85E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.37|P-value:1.65E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.28|P-value:2.39E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.44|P-value:5.56E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.22|P-value:3.09E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.46|P-value:5.11E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.24|P-value:2.82E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.77|P-value:1.72E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.72|P-value:2.05E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.47|P-value:4.05E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.27|P-value:9.64E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.54|P-value:3.93E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.81|P-value:1.62E-8 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.98|P-value:6.34E-9 ID:SGTC_1683|Compound:st010134|FD-Score:5.19|P-value:4.00E-7 ID:SGTC_1696|Compound:st025591|FD-Score:3.56|P-value:3.63E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.36|P-value:1.71E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.64|P-value:2.76E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.06|P-value:4.68E-5 ID:SGTC_1851|Compound:st056236|FD-Score:4.16|P-value:3.81E-5 ID:SGTC_1942|Compound:st076330|FD-Score:5.97|P-value:6.48E-9 ID:SGTC_2085|Compound:5307070|FD-Score:3.46|P-value:5.20E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.39|P-value:6.48E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.63|P-value:2.32E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.38|P-value:5.56E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.96|P-value:6.87E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.82|P-value:1.76E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.00|P-value:9.70E-7 ID:SGTC_2836|Compound:9010338|FD-Score:-3.91|P-value:8.34E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-3.57|P-value:2.85E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.75|P-value:1.50E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.66|P-value:4.61E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.38|P-value:6.79E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.23|P-value:9.17E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.22|P-value:3.05E-5 ID:SGTC_3235|Compound:9132602|FD-Score:4.23|P-value:2.87E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.28|P-value:9.39E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.00|P-value:7.14E-5 ID:SGTC_3335|Compound:9143315|FD-Score:3.27|P-value:9.77E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.82|P-value:1.44E-4

Top fitness defect scores for YMR316W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 12.50 9.0 µM 5.46E-33 cell wall 46 5.13E-36
2 SGTC_767 0929-0023 7.27 86.0 µM 2.16E-12 TRP & mitochondrial translation 15 1.82E-13
3 SGTC_138 0850-0259 6.86 40.9 µM 3.15E-11 cell wall 79 3.43E-12
4 SGTC_729 4092-0585 6.22 94.1 µM 1.57E-9 2 2.47E-10
5 SGTC_1680 diphenhydramine 5.98 100.0 µM 6.34E-9 NEO1 6 1.14E-9
6 SGTC_1942 st076330 5.97 65.2 µM 6.48E-9 3 1.17E-9
7 SGTC_2605 digitonin 5.96 300.0 nM 6.87E-9 3 1.25E-9
8 SGTC_1661 st013063 5.81 9.7 µM 1.62E-8 6 3.20E-9
9 SGTC_1683 st010134 5.19 710.0 nM 4.00E-7 9 1.07E-7
10 SGTC_2697 mebhydrolin 5.00 72.4 µM 9.70E-7 NEO1 45 2.82E-7
11 SGTC_190 3970-0790 4.99 3.7 µM 1.04E-6 1 3.03E-7
12 SGTC_763 3453-1109 4.96 128.0 µM 1.17E-6 6 3.45E-7
13 SGTC_513 4245-1575 4.69 41.7 µM 4.06E-6 unfolded protein response 85 1.35E-6
14 SGTC_3129 9127257 4.66 49.5 µM 4.61E-6 9 1.55E-6
15 SGTC_1105 epirubicin 4.37 18.1 µM 1.65E-5 anthracycline transcription coupled DNA repair 14 6.28E-6
16 SGTC_759 3486-0358 4.36 89.3 µM 1.67E-5 14 6.36E-6
17 SGTC_1715 st032160 4.36 10.2 µM 1.71E-5 35 6.54E-6
18 SGTC_1385 3091-4834 4.28 14.1 µM 2.39E-5 RPP1 & pyrimidine depletion 14 9.43E-6
19 SGTC_1543 azetidyl-2-carboxylic acid 4.24 198.0 µM 2.82E-5 7 1.13E-5
20 SGTC_3235 9132602 4.23 49.5 µM 2.87E-5 17 1.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 3.90E-55 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.252 1.39E-49 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.237 3.91E-44 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.233 1.79E-42 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.230 1.29E-41 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.225 1.13E-39 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.214 4.71E-36 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.210 6.58E-35 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.205 2.84E-33 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.202 3.38E-32 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.196 2.24E-30 YJL059W YHC3 hom Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
0.192 2.53E-29 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.191 5.64E-29 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.189 2.66E-28 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.187 8.89E-28 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress