YMR319C / FET4

Low-affinity Fe(II) transporter of the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR319C / FET4

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:-4.09|P-value:8.78E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.99|P-value:7.36E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.47|P-value:1.56E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.68|P-value:1.84E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.53|P-value:2.84E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.45|P-value:4.59E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.52|P-value:2.91E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-4.42|P-value:3.56E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:10.70|P-value:1.55E-16 ID:SGTC_576|Compound:1073-0113|FD-Score:5.43|P-value:1.82E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.55|P-value:2.69E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.60|P-value:2.34E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.37|P-value:4.46E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.63|P-value:2.25E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:6.17|P-value:1.34E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:5.90|P-value:3.53E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.36|P-value:4.22E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.64|P-value:8.80E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:6.87|P-value:8.45E-8 ID:SGTC_856|Compound:0433-0016|FD-Score:4.28|P-value:5.62E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:9.98|P-value:1.40E-14 ID:SGTC_881|Compound:0833-0569|FD-Score:4.13|P-value:8.46E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.47|P-value:1.58E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:7.09|P-value:3.30E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.25|P-value:5.72E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:9.69|P-value:7.83E-14 ID:SGTC_1002|Compound:4049-0206|FD-Score:-4.68|P-value:1.68E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.90|P-value:9.80E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.19|P-value:7.14E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.17|P-value:7.60E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.20|P-value:7.09E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.53|P-value:2.84E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.55|P-value:1.19E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:9.06|P-value:2.56E-12 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.33|P-value:2.54E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.25|P-value:6.12E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:10.30|P-value:1.70E-15 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.45|P-value:4.61E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.48|P-value:1.51E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.38|P-value:4.37E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.92|P-value:6.82E-8 ID:SGTC_1659|Compound:st012954|FD-Score:4.28|P-value:5.62E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.46|P-value:3.47E-4 ID:SGTC_1760|Compound:st045453|FD-Score:6.00|P-value:2.45E-6 ID:SGTC_1792|Compound:st045773|FD-Score:4.18|P-value:7.36E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.93|P-value:8.87E-5 ID:SGTC_1884|Compound:5633444|FD-Score:13.60|P-value:1.44E-25 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.07|P-value:9.25E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-4.15|P-value:7.44E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.28|P-value:2.98E-5 ID:SGTC_2003|Compound:4023581|FD-Score:5.89|P-value:3.75E-6 ID:SGTC_2061|Compound:5245884|FD-Score:4.81|P-value:1.28E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.54|P-value:2.78E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.68|P-value:7.59E-6 ID:SGTC_2183|Compound:6420625|FD-Score:4.90|P-value:9.72E-5 ID:SGTC_2218|Compound:6965428|FD-Score:-4.14|P-value:7.57E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.23|P-value:6.52E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.12|P-value:4.86E-5 ID:SGTC_2340|Compound:7987427|FD-Score:5.29|P-value:2.82E-5 ID:SGTC_2352|Compound:9027995|FD-Score:7.41|P-value:8.56E-9 ID:SGTC_2385|Compound:9074692|FD-Score:6.81|P-value:1.08E-7 ID:SGTC_2401|Compound:5128683|FD-Score:4.73|P-value:1.61E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-4.36|P-value:4.25E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.44|P-value:3.66E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.18|P-value:6.85E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.63|P-value:9.29E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.25|P-value:5.65E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:6.14|P-value:1.50E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:-5.26|P-value:2.87E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.79|P-value:1.36E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:5.40|P-value:1.97E-5 ID:SGTC_2780|Compound:5215298|FD-Score:4.63|P-value:2.18E-4 ID:SGTC_2796|Compound:7949634|FD-Score:6.34|P-value:7.03E-7 ID:SGTC_2800|Compound:7887935|FD-Score:4.36|P-value:4.64E-4 ID:SGTC_2801|Compound:7907800|FD-Score:4.88|P-value:1.04E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.44|P-value:3.66E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-5.24|P-value:3.05E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-4.94|P-value:7.75E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-4.19|P-value:6.64E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.10|P-value:8.43E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.09|P-value:9.33E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.93|P-value:8.87E-5 ID:SGTC_3062|Compound:9077494|FD-Score:5.49|P-value:1.49E-5 ID:SGTC_3197|Compound:9113331|FD-Score:5.05|P-value:6.15E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.12|P-value:8.62E-4 ID:SGTC_3252|Compound:9135871|FD-Score:6.19|P-value:1.25E-6 ID:SGTC_3296|Compound:9122258|FD-Score:4.46|P-value:3.45E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-4.74|P-value:1.43E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-4.09|P-value:8.78E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.99|P-value:7.36E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.47|P-value:1.56E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.68|P-value:1.84E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.53|P-value:2.84E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.45|P-value:4.59E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.52|P-value:2.91E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-4.42|P-value:3.56E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:10.70|P-value:1.55E-16 ID:SGTC_576|Compound:1073-0113|FD-Score:5.43|P-value:1.82E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.55|P-value:2.69E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.60|P-value:2.34E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.37|P-value:4.46E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.63|P-value:2.25E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:6.17|P-value:1.34E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:5.90|P-value:3.53E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.36|P-value:4.22E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.64|P-value:8.80E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:6.87|P-value:8.45E-8 ID:SGTC_856|Compound:0433-0016|FD-Score:4.28|P-value:5.62E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:9.98|P-value:1.40E-14 ID:SGTC_881|Compound:0833-0569|FD-Score:4.13|P-value:8.46E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.47|P-value:1.58E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:7.09|P-value:3.30E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.25|P-value:5.72E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:9.69|P-value:7.83E-14 ID:SGTC_1002|Compound:4049-0206|FD-Score:-4.68|P-value:1.68E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.90|P-value:9.80E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.19|P-value:7.14E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.17|P-value:7.60E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.20|P-value:7.09E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.53|P-value:2.84E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.55|P-value:1.19E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:9.06|P-value:2.56E-12 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.33|P-value:2.54E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.25|P-value:6.12E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:10.30|P-value:1.70E-15 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.45|P-value:4.61E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.48|P-value:1.51E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.38|P-value:4.37E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.92|P-value:6.82E-8 ID:SGTC_1659|Compound:st012954|FD-Score:4.28|P-value:5.62E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.46|P-value:3.47E-4 ID:SGTC_1760|Compound:st045453|FD-Score:6.00|P-value:2.45E-6 ID:SGTC_1792|Compound:st045773|FD-Score:4.18|P-value:7.36E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.93|P-value:8.87E-5 ID:SGTC_1884|Compound:5633444|FD-Score:13.60|P-value:1.44E-25 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.07|P-value:9.25E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-4.15|P-value:7.44E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.28|P-value:2.98E-5 ID:SGTC_2003|Compound:4023581|FD-Score:5.89|P-value:3.75E-6 ID:SGTC_2061|Compound:5245884|FD-Score:4.81|P-value:1.28E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.54|P-value:2.78E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.68|P-value:7.59E-6 ID:SGTC_2183|Compound:6420625|FD-Score:4.90|P-value:9.72E-5 ID:SGTC_2218|Compound:6965428|FD-Score:-4.14|P-value:7.57E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.23|P-value:6.52E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.12|P-value:4.86E-5 ID:SGTC_2340|Compound:7987427|FD-Score:5.29|P-value:2.82E-5 ID:SGTC_2352|Compound:9027995|FD-Score:7.41|P-value:8.56E-9 ID:SGTC_2385|Compound:9074692|FD-Score:6.81|P-value:1.08E-7 ID:SGTC_2401|Compound:5128683|FD-Score:4.73|P-value:1.61E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-4.36|P-value:4.25E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.44|P-value:3.66E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.18|P-value:6.85E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.63|P-value:9.29E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.25|P-value:5.65E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:6.14|P-value:1.50E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:-5.26|P-value:2.87E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.79|P-value:1.36E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:5.40|P-value:1.97E-5 ID:SGTC_2780|Compound:5215298|FD-Score:4.63|P-value:2.18E-4 ID:SGTC_2796|Compound:7949634|FD-Score:6.34|P-value:7.03E-7 ID:SGTC_2800|Compound:7887935|FD-Score:4.36|P-value:4.64E-4 ID:SGTC_2801|Compound:7907800|FD-Score:4.88|P-value:1.04E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.44|P-value:3.66E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-5.24|P-value:3.05E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-4.94|P-value:7.75E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-4.19|P-value:6.64E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.10|P-value:8.43E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.09|P-value:9.33E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.93|P-value:8.87E-5 ID:SGTC_3062|Compound:9077494|FD-Score:5.49|P-value:1.49E-5 ID:SGTC_3197|Compound:9113331|FD-Score:5.05|P-value:6.15E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.12|P-value:8.62E-4 ID:SGTC_3252|Compound:9135871|FD-Score:6.19|P-value:1.25E-6 ID:SGTC_3296|Compound:9122258|FD-Score:4.46|P-value:3.45E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-4.74|P-value:1.43E-4

Top fitness defect scores for YMR319C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1884 5633444 13.60 25.0 µM 1.44E-25 redox potentiating 6 1.39E-42
2 SGTC_525 k781-2675 10.70 26.7 µM 1.55E-16 redox potentiating 5 4.01E-27
3 SGTC_1453 4237-0541 10.30 195.0 µM 1.70E-15 heme biosynthesis & mitochondrial translocase 1 2.40E-25
4 SGTC_875 0709-0210 9.98 25.7 µM 1.40E-14 fatty acid desaturase (OLE1) 5 8.88E-24
5 SGTC_978 1416-0512 9.69 87.4 µM 7.83E-14 redox potentiating 2 1.68E-22
6 SGTC_1165 k072-0275 9.06 30.3 µM 2.56E-12 4 6.44E-20
7 SGTC_2352 9027995 7.41 87.8 µM 8.56E-9 tubulin folding & SWR complex 7 6.54E-14
8 SGTC_976 1348-1067 7.09 47.6 µM 3.30E-8 60S ribosome export 1 6.49E-13
9 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 6.92 54.9 µM 6.82E-8 redox potentiating 26 2.23E-12
10 SGTC_824 1304-0008 6.87 100.0 µM 8.45E-8 DNA damage response 4 3.21E-12
11 SGTC_2385 9074692 6.81 200.0 µM 1.08E-7 6 4.85E-12
12 SGTC_637 1181-0519 6.63 7.3 µM 2.25E-7 fatty acid desaturase (OLE1) 45 1.69E-11
13 SGTC_384 k007-0144 6.45 5.2 µM 4.59E-7 ERAD & cell cycle 22 5.67E-11
14 SGTC_1505 k297-0037 6.45 20.6 µM 4.61E-7 5 5.71E-11
15 SGTC_2796 7949634 6.34 45.5 µM 7.03E-7 3 1.17E-10
16 SGTC_3252 9135871 6.19 49.5 µM 1.25E-6 1 3.10E-10
17 SGTC_768 0384-0033 6.17 77.3 µM 1.34E-6 fatty acid desaturase (OLE1) 36 3.48E-10
18 SGTC_2657 nystatin 6.14 74.4 µM 1.50E-6 1 4.22E-10
19 SGTC_1760 st045453 6.00 10.4 µM 2.45E-6 NEO1-PIK1 81 9.66E-10
20 SGTC_801 0866-0028 5.90 10.1 µM 3.53E-6 4 1.80E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 5.75E-31 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.188 7.18E-28 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.179 1.37E-25 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.169 6.03E-23 YML012C-A_d YML012C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
0.169 6.38E-23 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.168 9.84E-23 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.163 2.34E-21 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.162 4.48E-21 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.162 5.28E-21 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.159 2.75E-20 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.158 3.30E-20 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.157 5.38E-20 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.153 5.06E-19 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.153 5.61E-19 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.151 1.40E-18 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome