YMR320W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR320W / YMR320W

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:2.58E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.94|P-value:9.08E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.20|P-value:3.34E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.85|P-value:2.30E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.03|P-value:6.53E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.12|P-value:6.39E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.53|P-value:9.02E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.27|P-value:2.60E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.02|P-value:6.98E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.16|P-value:5.18E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:4.01|P-value:1.07E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.95|P-value:8.57E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.16|P-value:5.14E-6 ID:SGTC_529|Compound:4076-0302|FD-Score:3.29|P-value:2.49E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:4.88|P-value:1.18E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.20|P-value:3.41E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.74|P-value:3.75E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:-2.99|P-value:7.52E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.51|P-value:2.62E-12 ID:SGTC_601|Compound:0986-0029|FD-Score:3.90|P-value:1.75E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.53|P-value:9.12E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:3.02|P-value:6.97E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.83|P-value:2.51E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.43|P-value:1.31E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:3.94|P-value:1.49E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.28|P-value:2.55E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.17|P-value:4.86E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.02|P-value:6.64E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.65|P-value:5.45E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.23|P-value:2.95E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.22|P-value:3.17E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.67|P-value:4.99E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.19|P-value:3.63E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.13|P-value:4.51E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.37|P-value:6.32E-9 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.94|P-value:9.37E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.38|P-value:1.74E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.38|P-value:1.70E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.30|P-value:2.28E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.23|P-value:3.60E-6 ID:SGTC_1608|Compound:st001473|FD-Score:3.22|P-value:3.28E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.16|P-value:3.87E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.06|P-value:5.89E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.70|P-value:4.39E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.05|P-value:6.17E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.63|P-value:6.00E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.23|P-value:3.08E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.03|P-value:9.68E-6 ID:SGTC_2074|Compound:5212007|FD-Score:-2.94|P-value:9.01E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.35|P-value:1.93E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.84|P-value:1.38E-7 ID:SGTC_2340|Compound:7987427|FD-Score:3.71|P-value:4.14E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.05|P-value:6.20E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.01|P-value:6.80E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.53|P-value:7.81E-7 ID:SGTC_2384|Compound:9036245|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_2401|Compound:5128683|FD-Score:2.95|P-value:8.78E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.35|P-value:2.01E-6 ID:SGTC_2570|Compound:licareol|FD-Score:3.30|P-value:2.33E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.50|P-value:1.02E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.55|P-value:2.07E-9 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.50|P-value:9.88E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.96|P-value:1.29E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.64|P-value:5.82E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.44|P-value:1.28E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.67|P-value:5.14E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.30|P-value:2.47E-6 ID:SGTC_2845|Compound:9003024|FD-Score:4.13|P-value:6.00E-6 ID:SGTC_2882|Compound:9058044|FD-Score:6.09|P-value:5.50E-11 ID:SGTC_2952|Compound:9073731|FD-Score:3.23|P-value:3.08E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.45|P-value:1.28E-4 ID:SGTC_3047|Compound:9092122|FD-Score:5.61|P-value:1.40E-9 ID:SGTC_3130|Compound:9127414|FD-Score:5.05|P-value:4.35E-8 ID:SGTC_3133|Compound:9127736|FD-Score:4.82|P-value:1.58E-7 ID:SGTC_3154|Compound:9100113|FD-Score:-3.21|P-value:3.30E-4 ID:SGTC_3155|Compound:9099265|FD-Score:2.99|P-value:7.56E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.74|P-value:2.52E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:2.58E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.94|P-value:9.08E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.20|P-value:3.34E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.85|P-value:2.30E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.03|P-value:6.53E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.12|P-value:6.39E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.53|P-value:9.02E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.27|P-value:2.60E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.02|P-value:6.98E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.16|P-value:5.18E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:4.01|P-value:1.07E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.95|P-value:8.57E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.16|P-value:5.14E-6 ID:SGTC_529|Compound:4076-0302|FD-Score:3.29|P-value:2.49E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:4.88|P-value:1.18E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.20|P-value:3.41E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.74|P-value:3.75E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:-2.99|P-value:7.52E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.51|P-value:2.62E-12 ID:SGTC_601|Compound:0986-0029|FD-Score:3.90|P-value:1.75E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.53|P-value:9.12E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:3.02|P-value:6.97E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.83|P-value:2.51E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.43|P-value:1.31E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:3.94|P-value:1.49E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.28|P-value:2.55E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.17|P-value:4.86E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.02|P-value:6.64E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.65|P-value:5.45E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.23|P-value:2.95E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.22|P-value:3.17E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.67|P-value:4.99E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.19|P-value:3.63E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.13|P-value:4.51E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.37|P-value:6.32E-9 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.94|P-value:9.37E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.38|P-value:1.74E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.38|P-value:1.70E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.30|P-value:2.28E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.23|P-value:3.60E-6 ID:SGTC_1608|Compound:st001473|FD-Score:3.22|P-value:3.28E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.16|P-value:3.87E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.06|P-value:5.89E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.70|P-value:4.39E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.05|P-value:6.17E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.63|P-value:6.00E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.23|P-value:3.08E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.03|P-value:9.68E-6 ID:SGTC_2074|Compound:5212007|FD-Score:-2.94|P-value:9.01E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.35|P-value:1.93E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.84|P-value:1.38E-7 ID:SGTC_2340|Compound:7987427|FD-Score:3.71|P-value:4.14E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.05|P-value:6.20E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.01|P-value:6.80E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.53|P-value:7.81E-7 ID:SGTC_2384|Compound:9036245|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_2401|Compound:5128683|FD-Score:2.95|P-value:8.78E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.35|P-value:2.01E-6 ID:SGTC_2570|Compound:licareol|FD-Score:3.30|P-value:2.33E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.50|P-value:1.02E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.55|P-value:2.07E-9 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.50|P-value:9.88E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.96|P-value:1.29E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.64|P-value:5.82E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.44|P-value:1.28E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.67|P-value:5.14E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-4.30|P-value:2.47E-6 ID:SGTC_2845|Compound:9003024|FD-Score:4.13|P-value:6.00E-6 ID:SGTC_2882|Compound:9058044|FD-Score:6.09|P-value:5.50E-11 ID:SGTC_2952|Compound:9073731|FD-Score:3.23|P-value:3.08E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.45|P-value:1.28E-4 ID:SGTC_3047|Compound:9092122|FD-Score:5.61|P-value:1.40E-9 ID:SGTC_3130|Compound:9127414|FD-Score:5.05|P-value:4.35E-8 ID:SGTC_3133|Compound:9127736|FD-Score:4.82|P-value:1.58E-7 ID:SGTC_3154|Compound:9100113|FD-Score:-3.21|P-value:3.30E-4 ID:SGTC_3155|Compound:9099265|FD-Score:2.99|P-value:7.56E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.74|P-value:2.52E-7

Top fitness defect scores for YMR320W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_594 1487-1584 6.51 10.8 µM 2.62E-12 4 3.82E-11
2 SGTC_2882 9058044 6.09 58.4 µM 5.50E-11 3 5.78E-10
3 SGTC_3047 9092122 5.61 49.5 µM 1.40E-9 2 1.04E-8
4 SGTC_2596 sinensetin 5.55 100.0 µM 2.07E-9 8 1.47E-8
5 SGTC_1203 3992-3522 5.37 103.0 µM 6.32E-9 9 3.97E-8
6 SGTC_3130 9127414 5.05 49.5 µM 4.35E-8 9 2.22E-7
7 SGTC_553 k007-0256 4.88 45.7 µM 1.18E-7 heme biosynthesis & mitochondrial translocase 11 5.41E-7
8 SGTC_3133 9127736 4.82 49.5 µM 1.58E-7 10 7.04E-7
9 SGTC_3224 9130643 4.74 49.5 µM 2.52E-7 RPP1 & pyrimidine depletion 11 1.07E-6
10 SGTC_2370 9071495 4.53 200.0 µM 7.81E-7 mitochondrial processes 17 2.93E-6
11 SGTC_766 1391-0721 4.43 126.0 µM 1.31E-6 6 4.64E-6
12 SGTC_2488 5268135 4.35 45.7 µM 2.01E-6 39 6.80E-6
13 SGTC_1451 4152-0210 4.23 104.0 µM 3.60E-6 17 1.15E-5
14 SGTC_863 0466-0191 4.17 129.0 µM 4.86E-6 cell wall 62 1.50E-5
15 SGTC_431 k089-0097 4.16 107.0 µM 5.14E-6 iron homeostasis 35 1.58E-5
16 SGTC_341 1486-1430 4.16 230.0 µM 5.18E-6 20 1.59E-5
17 SGTC_2845 9003024 4.13 43.0 µM 6.00E-6 amide catabolism 39 1.81E-5
18 SGTC_270 tamoxifen 4.12 5.5 µM 6.39E-6 NEO1 22 1.91E-5
19 SGTC_2009 4012297 4.03 12.1 µM 9.68E-6 cell wall signaling 58 2.77E-5
20 SGTC_422 cantharidin 4.01 155.0 µM 1.07E-5 cell wall signaling 56 3.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.60E-8 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.090 1.78E-7 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.086 5.43E-7 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.085 8.89E-7 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.084 1.05E-6 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.079 5.06E-6 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.079 5.12E-6 YGL208W SIP2 hom One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
0.075 1.43E-5 YJL176C SWI3 hom Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions
0.074 1.98E-5 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.070 4.52E-5 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.070 4.81E-5 YML022W APT1 hom Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication
0.069 6.93E-5 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.067 1.04E-4 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.066 1.24E-4 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.066 1.25E-4 YLR303W MET17 hom Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis