YMR326C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR326C / YMR326C

Click on Significant Values for Screen Details ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.45|P-value:3.00E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.08|P-value:9.58E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.11|P-value:8.58E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.68|P-value:1.05E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.04|P-value:2.39E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.29|P-value:4.63E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.15|P-value:1.14E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:4.57|P-value:2.16E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.21|P-value:6.08E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.72|P-value:9.17E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.62|P-value:1.34E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.13|P-value:8.12E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.29|P-value:4.57E-4 ID:SGTC_1630|Compound:st005209|FD-Score:5.06|P-value:1.83E-7 ID:SGTC_1726|Compound:st035556|FD-Score:5.49|P-value:1.79E-8 ID:SGTC_1916|Compound:st067606|FD-Score:3.77|P-value:7.48E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-3.40|P-value:3.66E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.41|P-value:3.01E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.37|P-value:3.52E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:-3.22|P-value:6.91E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.16|P-value:7.40E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.20|P-value:1.45E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.54|P-value:1.84E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.45|P-value:3.00E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.08|P-value:9.58E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.11|P-value:8.58E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.68|P-value:1.05E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.04|P-value:2.39E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.29|P-value:4.63E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.15|P-value:1.14E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:4.57|P-value:2.16E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.21|P-value:6.08E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.72|P-value:9.17E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.62|P-value:1.34E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.13|P-value:8.12E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.29|P-value:4.57E-4 ID:SGTC_1630|Compound:st005209|FD-Score:5.06|P-value:1.83E-7 ID:SGTC_1726|Compound:st035556|FD-Score:5.49|P-value:1.79E-8 ID:SGTC_1916|Compound:st067606|FD-Score:3.77|P-value:7.48E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-3.40|P-value:3.66E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.41|P-value:3.01E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.37|P-value:3.52E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:-3.22|P-value:6.91E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.16|P-value:7.40E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.20|P-value:1.45E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.54|P-value:1.84E-4

Top fitness defect scores for YMR326C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1726 st035556 5.49 14.6 µM 1.79E-8 14 2.04E-8
2 SGTC_619 1652-1634 5.15 108.0 µM 1.14E-7 PDR1 6 1.28E-7
3 SGTC_1630 st005209 5.06 31.3 µM 1.83E-7 9 2.06E-7
4 SGTC_739 1486-1183 4.57 203.0 µM 2.16E-6 12 2.40E-6
5 SGTC_602 3130-1533 4.04 38.1 µM 2.39E-5 15 2.63E-5
6 SGTC_1916 st067606 3.77 49.2 µM 7.48E-5 44 8.19E-5
7 SGTC_1187 1391-0724 3.72 117.0 µM 9.17E-5 amide catabolism 22 1.00E-4
8 SGTC_519 k048-0011 3.68 62.8 µM 1.05E-4 29 1.15E-4
9 SGTC_1257 0669-0121 3.62 16.0 µM 1.34E-4 39 1.47E-4
10 SGTC_3128 9127691 3.54 49.5 µM 1.84E-4 29 2.01E-4
11 SGTC_2533 agelasine 3.41 13.7 µM 3.01E-4 ERG2 73 3.26E-4
12 SGTC_2605 digitonin 3.37 300.0 nM 3.52E-4 55 3.82E-4
13 SGTC_1626 st003712 3.29 1.8 µM 4.57E-4 49 4.95E-4
14 SGTC_604 1000-0114 3.29 314.0 µM 4.63E-4 51 5.01E-4
15 SGTC_1075 aripiprazole 3.21 15.2 µM 6.08E-4 65 6.57E-4
16 SGTC_1283 0922-0125 3.19 16.4 µM 6.54E-4 49 7.07E-4
17 SGTC_2829 7992743 3.16 58.4 µM 7.40E-4 77 7.99E-4
18 SGTC_1354 1498-1681 3.13 81.0 µM 8.12E-4 55 8.77E-4
19 SGTC_2638 epoxomicin 3.12 18.0 µM 8.26E-4 63 8.91E-4
20 SGTC_258 haloperidol 3.11 50.8 µM 8.58E-4 fatty acid desaturase (OLE1) 67 9.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.29E-13 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.105 8.94E-10 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.100 5.86E-9 YML088W UFO1 hom F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
0.099 1.03E-8 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.095 3.25E-8 YPL203W TPK2 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase
0.094 5.88E-8 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.091 1.34E-7 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.091 1.38E-7 YPL088W_p YPL088W_p hom Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.089 2.20E-7 YOL063C CRT10 hom Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat
0.089 2.24E-7 YDR425W SNX41 hom Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p
0.086 5.39E-7 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.086 5.52E-7 YDL104C QRI7 hom Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
0.086 5.73E-7 YBL012C_d YBL012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.76E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.084 1.04E-6 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats