YNL002C / RLP7

Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL002C / RLP7

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:5.44|P-value:9.40E-8 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.35|P-value:6.55E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.72|P-value:1.79E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.60|P-value:5.25E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:5.46|P-value:8.74E-8 ID:SGTC_627|Compound:1391-0720|FD-Score:3.41|P-value:5.28E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.33|P-value:7.06E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.49|P-value:4.10E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:6.32E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.55|P-value:3.31E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.48|P-value:4.19E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.71|P-value:1.89E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:8.53|P-value:1.83E-16 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:6.88|P-value:2.32E-11 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.34|P-value:6.68E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.89|P-value:1.13E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.50|P-value:8.17E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.17|P-value:3.23E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.92|P-value:8.58E-5 ID:SGTC_1660|Compound:st012960|FD-Score:3.25|P-value:8.94E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.63|P-value:2.49E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.38|P-value:5.92E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.24|P-value:9.48E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.54|P-value:3.43E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.42|P-value:5.13E-4 ID:SGTC_1927|Compound:st060202|FD-Score:5.00|P-value:8.62E-7 ID:SGTC_1932|Compound:st074806|FD-Score:3.22|P-value:9.87E-4 ID:SGTC_1961|Compound:st076550|FD-Score:4.22|P-value:2.60E-5 ID:SGTC_1973|Compound:st070275|FD-Score:3.27|P-value:8.59E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.54|P-value:3.37E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.48|P-value:4.85E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.83|P-value:1.19E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.74|P-value:1.68E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.73|P-value:2.12E-8 ID:SGTC_2330|Compound:7979373|FD-Score:-3.80|P-value:1.60E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.38|P-value:5.85E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.42|P-value:6.09E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.61|P-value:6.08E-6 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.75|P-value:1.59E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:-3.58|P-value:3.49E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.33|P-value:7.00E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.56|P-value:6.25E-6 ID:SGTC_2874|Compound:9043904|FD-Score:3.28|P-value:8.31E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.45|P-value:4.73E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.27|P-value:9.88E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.93|P-value:8.30E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.90|P-value:9.41E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.85|P-value:1.13E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.02|P-value:7.62E-7 ID:SGTC_3286|Compound:9117135|FD-Score:4.55|P-value:6.67E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:5.44|P-value:9.40E-8 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.35|P-value:6.55E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.72|P-value:1.79E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.60|P-value:5.25E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:5.46|P-value:8.74E-8 ID:SGTC_627|Compound:1391-0720|FD-Score:3.41|P-value:5.28E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.33|P-value:7.06E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.49|P-value:4.10E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:6.32E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.55|P-value:3.31E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.48|P-value:4.19E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.71|P-value:1.89E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:8.53|P-value:1.83E-16 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:6.88|P-value:2.32E-11 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.34|P-value:6.68E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.89|P-value:1.13E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.50|P-value:8.17E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.17|P-value:3.23E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.92|P-value:8.58E-5 ID:SGTC_1660|Compound:st012960|FD-Score:3.25|P-value:8.94E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.63|P-value:2.49E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.38|P-value:5.92E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.24|P-value:9.48E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.54|P-value:3.43E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.42|P-value:5.13E-4 ID:SGTC_1927|Compound:st060202|FD-Score:5.00|P-value:8.62E-7 ID:SGTC_1932|Compound:st074806|FD-Score:3.22|P-value:9.87E-4 ID:SGTC_1961|Compound:st076550|FD-Score:4.22|P-value:2.60E-5 ID:SGTC_1973|Compound:st070275|FD-Score:3.27|P-value:8.59E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.54|P-value:3.37E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.48|P-value:4.85E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.83|P-value:1.19E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.74|P-value:1.68E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.73|P-value:2.12E-8 ID:SGTC_2330|Compound:7979373|FD-Score:-3.80|P-value:1.60E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.38|P-value:5.85E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.42|P-value:6.09E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.61|P-value:6.08E-6 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.75|P-value:1.59E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:-3.58|P-value:3.49E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.33|P-value:7.00E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.56|P-value:6.25E-6 ID:SGTC_2874|Compound:9043904|FD-Score:3.28|P-value:8.31E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.45|P-value:4.73E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.27|P-value:9.88E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.93|P-value:8.30E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.90|P-value:9.41E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.85|P-value:1.13E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.02|P-value:7.62E-7 ID:SGTC_3286|Compound:9117135|FD-Score:4.55|P-value:6.67E-6

Top fitness defect scores for YNL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1074 carmofur 8.53 3.8 µM 1.83E-16 exosome 7 7.52E-18 0.45
2 SGTC_1077 5-fluorocytosine 6.88 377.0 nM 2.32E-11 exosome 9 2.93E-12 0.23
3 SGTC_2328 6201408 5.73 200.0 µM 2.12E-8 3 5.09E-9 0.32
4 SGTC_610 4215-0184 5.46 155.0 µM 8.74E-8 exosome 14 2.40E-8 0.02
5 SGTC_118 0083-0097 5.44 135.3 µM 9.40E-8 translation 8 2.60E-8 0.67
6 SGTC_3224 9130643 5.02 49.5 µM 7.62E-7 RPP1 & pyrimidine depletion 4 2.56E-7 0.41
7 SGTC_1927 st060202 5.00 13.8 µM 8.62E-7 2 2.93E-7 0.17
8 SGTC_486 niguldipine 4.60 82.0 µM 5.25E-6 amide catabolism 2 2.11E-6 0.26
9 SGTC_2798 7813637 4.56 45.5 µM 6.25E-6 10 2.55E-6 0.01
10 SGTC_3286 9117135 4.55 37.2 µM 6.67E-6 6 2.73E-6 0.01
11 SGTC_1386 3228-0095 4.50 33.8 µM 8.17E-6 2 3.41E-6 1.06
12 SGTC_1961 st076550 4.22 68.7 µM 2.60E-5 6 1.20E-5 0.04
13 SGTC_1388 3346-4487 4.17 254.0 µM 3.23E-5 1 1.53E-5 0.40
14 SGTC_3081 9117243 3.93 49.5 µM 8.30E-5 fatty acid desaturase (OLE1) 28 4.27E-5 0.00
15 SGTC_1466 k213-0079 3.92 57.5 µM 8.58E-5 14 4.43E-5 0.11
16 SGTC_3083 9117465 3.90 49.5 µM 9.41E-5 6 4.90E-5 0.13
17 SGTC_1698 5-fluorocytosine 3.86 1.1 µM 1.08E-4 exosome 14 5.70E-5 0.03
18 SGTC_3223 9129970 3.85 49.5 µM 1.13E-4 6 5.96E-5 0.17
19 SGTC_2192 5915882 3.83 198.5 µM 1.19E-4 RNA processing & uracil transport 15 6.33E-5 0.15
20 SGTC_2653 dihydrofissinolide 3.75 100.0 µM 1.59E-4 2 8.69E-5 0.29

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 2.87E-67 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.290 3.96E-66 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.282 4.08E-62 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.268 5.27E-56 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.223 6.87E-39 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.219 1.51E-37 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.206 1.42E-33 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.196 2.46E-30 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.190 1.35E-28 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.184 6.77E-27 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.171 2.05E-23 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.167 1.87E-22 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.149 5.05E-18 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.136 3.15E-15 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
0.131 3.46E-14 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp