YNL004W / HRB1

Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL004W / HRB1

Click on Significant Values for Screen Details ID:SGTC_280|Compound:3448-3607|FD-Score:3.96|P-value:2.58E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.31|P-value:2.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.08|P-value:8.62E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.27|P-value:6.36E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.11|P-value:1.33E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-4.43|P-value:1.68E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.05|P-value:9.71E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.31|P-value:3.06E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.24|P-value:7.19E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.82|P-value:4.78E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.07|P-value:8.98E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.16|P-value:4.32E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.18|P-value:3.98E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.36|P-value:3.07E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.96|P-value:1.60E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.75|P-value:4.02E-5 ID:SGTC_1805|Compound:st050013|FD-Score:3.25|P-value:4.60E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.40|P-value:3.38E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.25|P-value:4.67E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.51|P-value:1.91E-6 ID:SGTC_2505|Compound:galangin|FD-Score:3.21|P-value:5.43E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.14|P-value:4.74E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.19|P-value:5.75E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.24|P-value:4.86E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.75|P-value:6.54E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.08|P-value:5.78E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.96|P-value:2.58E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.31|P-value:2.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.08|P-value:8.62E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.27|P-value:6.36E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.11|P-value:1.33E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-4.43|P-value:1.68E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.05|P-value:9.71E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.20|P-value:5.50E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.31|P-value:3.06E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.24|P-value:7.19E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.82|P-value:4.78E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.07|P-value:8.98E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.16|P-value:4.32E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.18|P-value:3.98E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.36|P-value:3.07E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.96|P-value:1.60E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.75|P-value:4.02E-5 ID:SGTC_1805|Compound:st050013|FD-Score:3.25|P-value:4.60E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.40|P-value:3.38E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.25|P-value:4.67E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.51|P-value:1.91E-6 ID:SGTC_2505|Compound:galangin|FD-Score:3.21|P-value:5.43E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.14|P-value:4.74E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.19|P-value:5.75E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.24|P-value:4.86E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.75|P-value:6.54E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.08|P-value:5.78E-4

Top fitness defect scores for YNL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2175 5807670 4.51 165.3 µM 1.91E-6 15 3.18E-6
2 SGTC_2106 5357045 4.40 167.3 µM 3.38E-6 9 5.45E-6
3 SGTC_403 arphamenine a 4.27 50.0 µM 6.36E-6 60S ribosome export 14 9.91E-6
4 SGTC_1136 pergolide 4.24 1.1 µM 7.19E-6 31 1.11E-5
5 SGTC_2950 9072895 4.12 21.5 µM 1.26E-5 32 1.89E-5
6 SGTC_418 lividomycin a 4.11 100.0 µM 1.33E-5 9 2.00E-5
7 SGTC_280 3448-3607 3.96 3.0 µM 2.58E-5 60S ribosome export 8 3.72E-5
8 SGTC_1212 0520-0165 3.82 585.0 µM 4.78E-5 37 6.69E-5
9 SGTC_3203 9113543 3.75 49.5 µM 6.54E-5 38 8.99E-5
10 SGTC_797 k781-0471 3.62 270.0 µM 1.12E-4 RPP1 & pyrimidine depletion 34 1.49E-4
11 SGTC_359 0081-0058 3.54 15.9 µM 1.51E-4 60S ribosome export 61 1.99E-4
12 SGTC_1045 1348-1485 3.54 165.0 µM 1.53E-4 52 2.02E-4
13 SGTC_2751 anetholtrithion 3.53 17.2 µM 1.57E-4 36 2.06E-4
14 SGTC_398 bronopol 3.51 33.3 µM 1.70E-4 RNA processing & uracil transport 30 2.22E-4
15 SGTC_1972 st070201 3.50 17.4 µM 1.79E-4 37 2.34E-4
16 SGTC_1633 st005664 3.36 67.9 µM 3.07E-4 58 3.89E-4
17 SGTC_1805 st050013 3.25 60.3 µM 4.60E-4 18 5.72E-4
18 SGTC_2141 5621638 3.25 7.7 µM 4.67E-4 tubulin folding & SWR complex 53 5.80E-4
19 SGTC_1888 azatryptophan 3.24 97.5 µM 4.85E-4 40 6.02E-4
20 SGTC_3153 9100258 3.24 49.5 µM 4.86E-4 57 6.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.63E-9 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.104 1.80E-9 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.087 4.21E-7 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.082 2.13E-6 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.076 1.09E-5 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.075 1.45E-5 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.074 1.94E-5 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.073 2.34E-5 YDR424C DYN2 hom Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
0.072 3.26E-5 YIL020C HIS6 hom Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.071 4.10E-5 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.067 9.61E-5 YOR044W IRC23 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
0.066 1.21E-4 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
0.064 1.86E-4 YGL153W PEX14 hom Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
0.063 2.45E-4 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.063 2.73E-4 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions