YNL006W / LST8

Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL006W / LST8

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.56|P-value:4.24E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.31|P-value:1.29E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.97|P-value:6.48E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.32|P-value:1.20E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.28|P-value:1.42E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:2.81|P-value:9.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.49|P-value:3.66E-7 ID:SGTC_183|Compound:3914-0051|FD-Score:3.07|P-value:3.45E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.36|P-value:1.34E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.46|P-value:6.70E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:5.28|P-value:2.99E-9 ID:SGTC_548|Compound:1436-0017|FD-Score:4.34|P-value:8.77E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.21|P-value:2.42E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:5.44|P-value:1.03E-9 ID:SGTC_605|Compound:1315-0399|FD-Score:3.11|P-value:2.90E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.96|P-value:6.76E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:2.81|P-value:9.48E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.68|P-value:2.40E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.15|P-value:2.50E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:2.84|P-value:8.31E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.16|P-value:2.41E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:2.90|P-value:6.76E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.81|P-value:5.77E-8 ID:SGTC_910|Compound:3454-3003|FD-Score:4.99|P-value:1.93E-8 ID:SGTC_913|Compound:3487-1245|FD-Score:5.00|P-value:1.81E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:2.91|P-value:6.47E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.37|P-value:1.27E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.66|P-value:3.42E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.01|P-value:4.36E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.80|P-value:9.78E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.28|P-value:1.45E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.25|P-value:1.65E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:2.92|P-value:6.15E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.60|P-value:4.69E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.24|P-value:2.17E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.20|P-value:2.55E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.63|P-value:1.64E-7 ID:SGTC_2244|Compound:6635614|FD-Score:-3.25|P-value:2.11E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.81|P-value:1.31E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.56|P-value:2.68E-13 ID:SGTC_2395|Compound:5646831|FD-Score:-2.98|P-value:6.18E-4 ID:SGTC_2399|Compound:5884133|FD-Score:2.84|P-value:8.27E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.58|P-value:3.91E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.08|P-value:3.36E-4 ID:SGTC_2439|Compound:5492030|FD-Score:2.95|P-value:5.56E-4 ID:SGTC_2443|Compound:5493264|FD-Score:4.45|P-value:4.66E-7 ID:SGTC_2444|Compound:5485484|FD-Score:3.18|P-value:2.25E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:2.83|P-value:8.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.84|P-value:8.25E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.87|P-value:9.46E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.19|P-value:2.09E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.98|P-value:5.62E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.98|P-value:4.93E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.06|P-value:4.49E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.00|P-value:5.76E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.45|P-value:7.05E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.65|P-value:3.69E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.82|P-value:1.67E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.92|P-value:2.91E-8 ID:SGTC_3213|Compound:9129884|FD-Score:2.91|P-value:6.51E-4 ID:SGTC_3289|Compound:9119912|FD-Score:2.87|P-value:7.58E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.93|P-value:7.13E-6 ID:SGTC_3334|Compound:9142812|FD-Score:3.40|P-value:8.46E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:3.56|P-value:4.24E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.31|P-value:1.29E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.97|P-value:6.48E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.32|P-value:1.20E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.28|P-value:1.42E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:2.81|P-value:9.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.49|P-value:3.66E-7 ID:SGTC_183|Compound:3914-0051|FD-Score:3.07|P-value:3.45E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.36|P-value:1.34E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.46|P-value:6.70E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:5.28|P-value:2.99E-9 ID:SGTC_548|Compound:1436-0017|FD-Score:4.34|P-value:8.77E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.21|P-value:2.42E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:5.44|P-value:1.03E-9 ID:SGTC_605|Compound:1315-0399|FD-Score:3.11|P-value:2.90E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.96|P-value:6.76E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:2.81|P-value:9.48E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.68|P-value:2.40E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.15|P-value:2.50E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:2.84|P-value:8.31E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.16|P-value:2.41E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:2.90|P-value:6.76E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.81|P-value:5.77E-8 ID:SGTC_910|Compound:3454-3003|FD-Score:4.99|P-value:1.93E-8 ID:SGTC_913|Compound:3487-1245|FD-Score:5.00|P-value:1.81E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:2.91|P-value:6.47E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.37|P-value:1.27E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.66|P-value:3.42E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.01|P-value:4.36E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.80|P-value:9.78E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.28|P-value:1.45E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.25|P-value:1.65E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:2.92|P-value:6.15E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.60|P-value:4.69E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.24|P-value:2.17E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.20|P-value:2.55E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.63|P-value:1.64E-7 ID:SGTC_2244|Compound:6635614|FD-Score:-3.25|P-value:2.11E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.81|P-value:1.31E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.56|P-value:2.68E-13 ID:SGTC_2395|Compound:5646831|FD-Score:-2.98|P-value:6.18E-4 ID:SGTC_2399|Compound:5884133|FD-Score:2.84|P-value:8.27E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.58|P-value:3.91E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.08|P-value:3.36E-4 ID:SGTC_2439|Compound:5492030|FD-Score:2.95|P-value:5.56E-4 ID:SGTC_2443|Compound:5493264|FD-Score:4.45|P-value:4.66E-7 ID:SGTC_2444|Compound:5485484|FD-Score:3.18|P-value:2.25E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:2.83|P-value:8.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.84|P-value:8.25E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.87|P-value:9.46E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.19|P-value:2.09E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.98|P-value:5.62E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.98|P-value:4.93E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.06|P-value:4.49E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.00|P-value:5.76E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.45|P-value:7.05E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.65|P-value:3.69E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.82|P-value:1.67E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.92|P-value:2.91E-8 ID:SGTC_3213|Compound:9129884|FD-Score:2.91|P-value:6.51E-4 ID:SGTC_3289|Compound:9119912|FD-Score:2.87|P-value:7.58E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.93|P-value:7.13E-6 ID:SGTC_3334|Compound:9142812|FD-Score:3.40|P-value:8.46E-5

Top fitness defect scores for YNL006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2249 haloperidol 6.56 116.4 µM 2.68E-13 ergosterol depletion effects on membrane 15 2.71E-11 0.75
2 SGTC_593 1203-0218 5.44 61.7 µM 1.03E-9 1 2.63E-8 0.92
3 SGTC_538 2922-0838 5.28 53.3 µM 2.99E-9 Golgi 2 6.38E-8 1.06
4 SGTC_913 3487-1245 5.00 167.0 µM 1.81E-8 5 2.86E-7 0.10
5 SGTC_910 3454-3003 4.99 490.0 µM 1.93E-8 4 3.02E-7 1.15
6 SGTC_2967 9089538 4.92 49.9 µM 2.91E-8 4 4.25E-7 0.02
7 SGTC_908 3448-7491 4.81 47.7 µM 5.77E-8 mitochondrial stress 5 7.53E-7 0.30
8 SGTC_2241 6772625 4.63 37.8 µM 1.64E-7 5 1.80E-6 0.47
9 SGTC_173 1273-0061 4.49 2.7 µM 3.66E-7 mitochondrial stress 18 3.52E-6 0.11
10 SGTC_2443 5493264 4.45 126.7 µM 4.66E-7 3 4.30E-6 0.35
11 SGTC_548 1436-0017 4.34 110.0 µM 8.77E-7 TSC3-RPN4 4 7.29E-6 0.33
12 SGTC_2640 pentamidine 3.98 10.4 µM 5.62E-6 mitochondrial processes 15 3.44E-5 0.01
13 SGTC_3318 9139014 3.93 38.6 µM 7.13E-6 10 4.19E-5 0.03
14 SGTC_2246 7293507 3.81 91.6 µM 1.31E-5 11 6.94E-5 0.04
15 SGTC_662 k832-1615 3.68 104.0 µM 2.40E-5 6 1.16E-4 0.02
16 SGTC_2401 5128683 3.58 200.0 µM 3.91E-5 13 1.74E-4 0.05
17 SGTC_12 0849-0099 3.56 9.3 µM 4.24E-5 8 1.86E-4 0.22
18 SGTC_524 r073-0010 3.46 27.8 µM 6.70E-5 22 2.72E-4 0.05
19 SGTC_2849 9019321 3.45 13.0 µM 7.05E-5 11 2.84E-4 0.11
20 SGTC_3334 9142812 3.40 21.9 µM 8.46E-5 10 3.31E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.40E-11 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.111 1.15E-10 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.111 1.29E-10 YKL037W AIM26 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
0.109 2.36E-10 YMR043W MCM1 het Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
0.107 4.92E-10 YPL189W GUP2 hom Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog
0.103 2.46E-9 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.093 7.29E-8 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.092 1.06E-7 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.091 1.14E-7 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.090 1.63E-7 YIL109C SEC24 het Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.090 2.01E-7 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.089 2.80E-7 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.088 3.43E-7 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.086 5.56E-7 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
0.085 7.73E-7 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W