YNL010W_p

Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL010W / YNL010W

Click on Significant Values for Screen Details ID:SGTC_170|Compound:4197-0004|FD-Score:4.00|P-value:4.06E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-4.32|P-value:5.59E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.01|P-value:3.83E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.30|P-value:6.09E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-5.14|P-value:9.05E-8 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.16|P-value:6.06E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.62|P-value:1.84E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-4.25|P-value:7.63E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.11|P-value:7.23E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.62|P-value:1.10E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:5.66|P-value:1.07E-8 ID:SGTC_696|Compound:1560-0013|FD-Score:5.66|P-value:1.03E-8 ID:SGTC_736|Compound:0958-0254|FD-Score:3.18|P-value:9.23E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.60|P-value:1.52E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:3.46|P-value:3.42E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.43|P-value:3.82E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.40|P-value:4.22E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.66|P-value:1.58E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.30|P-value:3.72E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.61|P-value:1.90E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.66|P-value:1.59E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.04|P-value:9.20E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.14|P-value:6.47E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.88|P-value:6.70E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.38|P-value:7.79E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.00|P-value:4.13E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.61|P-value:1.12E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.29|P-value:6.18E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.43|P-value:3.74E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.83|P-value:8.01E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.48|P-value:3.09E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.82|P-value:8.46E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.56|P-value:2.35E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.41|P-value:4.06E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.29|P-value:6.29E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:10.90|P-value:1.62E-27 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.72|P-value:1.28E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.14|P-value:2.26E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.45|P-value:5.55E-6 ID:SGTC_2964|Compound:9083345|FD-Score:3.73|P-value:1.20E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.32|P-value:5.57E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.45|P-value:5.53E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.20|P-value:8.58E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.62|P-value:2.53E-6 ID:SGTC_3135|Compound:9127742|FD-Score:4.03|P-value:3.52E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.79|P-value:9.48E-5 ID:SGTC_3167|Compound:9103034|FD-Score:3.81|P-value:8.76E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.01|P-value:3.94E-5 ID:SGTC_3309|Compound:9129340|FD-Score:-3.19|P-value:5.43E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.00|P-value:4.06E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-4.32|P-value:5.59E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.01|P-value:3.83E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.30|P-value:6.09E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-5.14|P-value:9.05E-8 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.16|P-value:6.06E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.62|P-value:1.84E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-4.25|P-value:7.63E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.11|P-value:7.23E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.62|P-value:1.10E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:5.66|P-value:1.07E-8 ID:SGTC_696|Compound:1560-0013|FD-Score:5.66|P-value:1.03E-8 ID:SGTC_736|Compound:0958-0254|FD-Score:3.18|P-value:9.23E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.60|P-value:1.52E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:3.46|P-value:3.42E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.43|P-value:3.82E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.40|P-value:4.22E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.66|P-value:1.58E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.30|P-value:3.72E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.61|P-value:1.90E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.66|P-value:1.59E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.04|P-value:9.20E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.14|P-value:6.47E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.88|P-value:6.70E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.38|P-value:7.79E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.00|P-value:4.13E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.61|P-value:1.12E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.29|P-value:6.18E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.43|P-value:3.74E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.83|P-value:8.01E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.48|P-value:3.09E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.82|P-value:8.46E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.56|P-value:2.35E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.41|P-value:4.06E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.29|P-value:6.29E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:10.90|P-value:1.62E-27 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.72|P-value:1.28E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.14|P-value:2.26E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.45|P-value:5.55E-6 ID:SGTC_2964|Compound:9083345|FD-Score:3.73|P-value:1.20E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.32|P-value:5.57E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.45|P-value:5.53E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.20|P-value:8.58E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.62|P-value:2.53E-6 ID:SGTC_3135|Compound:9127742|FD-Score:4.03|P-value:3.52E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.79|P-value:9.48E-5 ID:SGTC_3167|Compound:9103034|FD-Score:3.81|P-value:8.76E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.01|P-value:3.94E-5 ID:SGTC_3309|Compound:9129340|FD-Score:-3.19|P-value:5.43E-4

Top fitness defect scores for YNL010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2565 isoliquiritigenin 10.90 100.0 µM 1.62E-27 1 9.86E-28
2 SGTC_696 1560-0013 5.66 611.0 µM 1.03E-8 8 7.43E-9
3 SGTC_648 0375-0473 5.66 33.3 µM 1.07E-8 4 7.70E-9
4 SGTC_868 0527-0199 5.60 213.0 µM 1.52E-8 fatty acid desaturase (OLE1) 7 1.10E-8
5 SGTC_3129 9127257 4.62 49.5 µM 2.53E-6 11 1.91E-6
6 SGTC_3123 9126162 4.45 49.5 µM 5.53E-6 10 4.21E-6
7 SGTC_2817 7995342 4.45 71.4 µM 5.55E-6 15 4.23E-6
8 SGTC_1731 st035964 4.38 63.0 µM 7.79E-6 19 5.95E-6
9 SGTC_2615 purpurogallin-4-carboxylic acid 4.14 100.0 µM 2.26E-5 redox potentiating 61 1.74E-5
10 SGTC_3135 9127742 4.03 49.5 µM 3.52E-5 17 2.73E-5
11 SGTC_421 streptovitacin 4.01 30.0 mM 3.83E-5 20 2.98E-5
12 SGTC_3304 9125678 4.01 46.1 µM 3.94E-5 45 3.07E-5
13 SGTC_170 4197-0004 4.00 226.0 µM 4.06E-5 17 3.16E-5
14 SGTC_1745 st081495 4.00 74.0 µM 4.13E-5 RNA processing & uracil transport 72 3.21E-5
15 SGTC_1678 st019265 3.88 80.2 µM 6.70E-5 60S ribosome export 19 5.24E-5
16 SGTC_2049 5262831 3.83 67.2 µM 8.01E-5 31 6.29E-5
17 SGTC_2486 5283202 3.82 22.4 µM 8.46E-5 37 6.64E-5
18 SGTC_3167 9103034 3.81 49.5 µM 8.76E-5 RPP1 & pyrimidine depletion 7 6.88E-5
19 SGTC_3151 9099821 3.79 49.5 µM 9.48E-5 26 7.45E-5
20 SGTC_2964 9083345 3.73 53.4 µM 1.20E-4 26 9.43E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.97E-19 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.101 5.03E-9 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.100 7.49E-9 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.091 1.22E-7 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.090 1.57E-7 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.090 1.94E-7 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.089 2.74E-7 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.088 3.34E-7 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.085 7.82E-7 YOR247W SRL1 hom Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication
0.084 1.00E-6 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.084 1.08E-6 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.084 1.16E-6 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.082 1.93E-6 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.081 2.66E-6 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.079 5.16E-6 YDL014W NOP1 het Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin