YNL012W / SPO1

Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL012W / SPO1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.44|P-value:2.31E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.42|P-value:1.53E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.73|P-value:7.03E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.42|P-value:1.57E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.93|P-value:9.55E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.15|P-value:6.72E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.76|P-value:3.70E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.09|P-value:5.49E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.05|P-value:9.78E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:5.25|P-value:1.87E-8 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.61|P-value:1.16E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.13|P-value:7.29E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.21|P-value:5.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.46|P-value:2.13E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.06|P-value:6.06E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.18|P-value:6.19E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.49|P-value:1.16E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.25|P-value:3.00E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.67|P-value:5.43E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.09|P-value:5.45E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.52|P-value:1.03E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.14|P-value:4.47E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.05|P-value:9.68E-4 ID:SGTC_1813|Compound:st051246|FD-Score:5.91|P-value:2.97E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:-5.36|P-value:2.00E-8 ID:SGTC_2165|Compound:5727197|FD-Score:3.79|P-value:3.23E-5 ID:SGTC_2197|Compound:6588183|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.93|P-value:1.78E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.53|P-value:1.60E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.94|P-value:2.87E-5 ID:SGTC_2268|Compound:7933382|FD-Score:4.44|P-value:1.51E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.18|P-value:3.93E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.57|P-value:1.41E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.81|P-value:5.16E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.37|P-value:1.88E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.08|P-value:8.67E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.30|P-value:3.93E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.37|P-value:1.91E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.11|P-value:5.05E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.96|P-value:2.71E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.23|P-value:3.22E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.17|P-value:6.38E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.40|P-value:1.64E-4 ID:SGTC_3198|Compound:9112019|FD-Score:2.99|P-value:7.83E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.17|P-value:5.81E-6 ID:SGTC_3303|Compound:9125618|FD-Score:2.99|P-value:7.93E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.44|P-value:2.31E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.42|P-value:1.53E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.73|P-value:7.03E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.42|P-value:1.57E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.93|P-value:9.55E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.15|P-value:6.72E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.76|P-value:3.70E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.09|P-value:5.49E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.05|P-value:9.78E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:5.25|P-value:1.87E-8 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.61|P-value:1.16E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.13|P-value:7.29E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.21|P-value:5.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.46|P-value:2.13E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.06|P-value:6.06E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.18|P-value:6.19E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.49|P-value:1.16E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.25|P-value:3.00E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.67|P-value:5.43E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.09|P-value:5.45E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.52|P-value:1.03E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.14|P-value:4.47E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.05|P-value:9.68E-4 ID:SGTC_1813|Compound:st051246|FD-Score:5.91|P-value:2.97E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:-5.36|P-value:2.00E-8 ID:SGTC_2165|Compound:5727197|FD-Score:3.79|P-value:3.23E-5 ID:SGTC_2197|Compound:6588183|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.93|P-value:1.78E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.53|P-value:1.60E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.94|P-value:2.87E-5 ID:SGTC_2268|Compound:7933382|FD-Score:4.44|P-value:1.51E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.18|P-value:3.93E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.57|P-value:1.41E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.81|P-value:5.16E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.37|P-value:1.88E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.08|P-value:8.67E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.30|P-value:3.93E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.37|P-value:1.91E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.11|P-value:5.05E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.96|P-value:2.71E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.23|P-value:3.22E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.17|P-value:6.38E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.40|P-value:1.64E-4 ID:SGTC_3198|Compound:9112019|FD-Score:2.99|P-value:7.83E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.17|P-value:5.81E-6 ID:SGTC_3303|Compound:9125618|FD-Score:2.99|P-value:7.93E-4

Top fitness defect scores for YNL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1813 st051246 5.91 8.6 µM 2.97E-10 TSC3-RPN4 2 1.67E-9
2 SGTC_561 1550-0330 5.25 72.9 µM 1.87E-8 4 7.68E-8
3 SGTC_2268 7933382 4.44 153.8 µM 1.51E-6 25 4.41E-6
4 SGTC_3264 9137442 4.17 49.5 µM 5.81E-6 11 1.53E-5
5 SGTC_2223 6903751 3.93 107.6 µM 1.78E-5 superoxide 11 4.28E-5
6 SGTC_2165 5727197 3.79 32.1 µM 3.23E-5 37 7.40E-5
7 SGTC_420 mitomycin C 3.76 81.9 mM 3.70E-5 22 8.40E-5
8 SGTC_1192 1488-0095 3.67 21.4 µM 5.43E-5 22 1.20E-4
9 SGTC_1600 coumarin 106 3.52 71.1 µM 1.03E-4 37 2.16E-4
10 SGTC_1075 aripiprazole 3.49 15.2 µM 1.16E-4 47 2.41E-4
11 SGTC_3259 9138485 3.46 49.5 µM 1.32E-4 22 2.71E-4
12 SGTC_2264 7948757 3.45 110.8 µM 1.37E-4 30 2.80E-4
13 SGTC_43 0570-0105 3.42 72.5 µM 1.53E-4 ERG2 141 3.10E-4
14 SGTC_2848 9016370 3.42 26.0 µM 1.55E-4 49 3.14E-4
15 SGTC_1063 disulfiram 3.42 1.8 µM 1.55E-4 43 3.15E-4
16 SGTC_310 1273-0058 3.42 1.1 µM 1.57E-4 mitochondrial stress 301 3.17E-4
17 SGTC_3136 9095672 3.40 49.5 µM 1.64E-4 46 3.32E-4
18 SGTC_1690 st023502 3.37 41.2 µM 1.87E-4 calcium & mitochondrial duress 22 3.73E-4
19 SGTC_2401 5128683 3.37 200.0 µM 1.88E-4 61 3.76E-4
20 SGTC_2594 a-mangostin 3.37 100.0 µM 1.91E-4 56 3.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.66E-9 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.087 4.57E-7 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.083 1.75E-6 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.082 2.17E-6 YOR376W-A_p YOR376W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.081 2.66E-6 YMR083W ADH3 hom Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
0.078 6.41E-6 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.073 2.30E-5 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.073 2.50E-5 YJR078W BNA2 hom Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.071 3.49E-5 YLR393W ATP10 hom Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
0.071 3.91E-5 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.070 4.43E-5 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.070 4.76E-5 YPL173W MRPL40 hom Mitochondrial ribosomal protein of the large subunit
0.070 5.05E-5 YPR116W RRG8 hom Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.070 5.39E-5 YPL064C CWC27 hom Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.068 7.73E-5 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader