YNL022C_p

Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL022C / YNL022C

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:2.95|P-value:9.12E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.18|P-value:4.40E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.21|P-value:3.96E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.30|P-value:2.49E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.13|P-value:5.32E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.84|P-value:2.94E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:2.99|P-value:8.01E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.25|P-value:3.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.62|P-value:5.61E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.23|P-value:3.58E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.44|P-value:1.41E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-2.96|P-value:9.88E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.03|P-value:1.06E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.78|P-value:3.37E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:2.95|P-value:9.13E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.99|P-value:8.92E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.02|P-value:7.15E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.85|P-value:2.73E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:5.96|P-value:1.67E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:3.64|P-value:6.22E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-2.97|P-value:9.54E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.86|P-value:2.40E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.59|P-value:7.50E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.61|P-value:5.91E-7 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.23|P-value:3.23E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.30|P-value:2.70E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.05|P-value:6.44E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.99|P-value:8.00E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.01|P-value:7.34E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.54|P-value:9.28E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.73|P-value:4.64E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.34|P-value:2.34E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.04|P-value:7.39E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.05|P-value:7.03E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.40|P-value:6.31E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:3.27|P-value:2.79E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.84|P-value:2.85E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-3.03|P-value:7.68E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.74|P-value:3.91E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.18|P-value:3.91E-4 ID:SGTC_2958|Compound:9077254|FD-Score:6.18|P-value:3.75E-11 ID:SGTC_3075|Compound:9116269|FD-Score:-3.91|P-value:2.06E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.36|P-value:1.95E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.17|P-value:4.07E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.76|P-value:4.10E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.40|P-value:1.84E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-7.05|P-value:6.86E-14 ID:SGTC_3216|Compound:9129716|FD-Score:3.67|P-value:5.53E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-6.61|P-value:2.01E-12 ID:SGTC_3246|Compound:9135460|FD-Score:-3.69|P-value:5.56E-5 ID:SGTC_3247|Compound:9135149|FD-Score:4.79|P-value:2.24E-7 ID:SGTC_3254|Compound:9136651|FD-Score:-4.05|P-value:1.10E-5 ID:SGTC_3257|Compound:9139206|FD-Score:-3.44|P-value:1.55E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.21|P-value:1.59E-14 ID:SGTC_3321|Compound:9137793|FD-Score:9.01|P-value:1.30E-21 ID:SGTC_3329|Compound:9141233|FD-Score:-3.33|P-value:2.48E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.89|P-value:2.07E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:2.95|P-value:9.12E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.18|P-value:4.40E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.21|P-value:3.96E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.30|P-value:2.49E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.13|P-value:5.32E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.84|P-value:2.94E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:2.99|P-value:8.01E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.25|P-value:3.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.62|P-value:5.61E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.23|P-value:3.58E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.44|P-value:1.41E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-2.96|P-value:9.88E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.03|P-value:1.06E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.78|P-value:3.37E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:2.95|P-value:9.13E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.99|P-value:8.92E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.02|P-value:7.15E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.85|P-value:2.73E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:5.96|P-value:1.67E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:3.64|P-value:6.22E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-2.97|P-value:9.54E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.86|P-value:2.40E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.59|P-value:7.50E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.61|P-value:5.91E-7 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.23|P-value:3.23E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.30|P-value:2.70E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.05|P-value:6.44E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.99|P-value:8.00E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.01|P-value:7.34E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.54|P-value:9.28E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.73|P-value:4.64E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.34|P-value:2.34E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.39|P-value:1.75E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.04|P-value:7.39E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.05|P-value:7.03E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.40|P-value:6.31E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:3.27|P-value:2.79E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.84|P-value:2.85E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-3.03|P-value:7.68E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.74|P-value:3.91E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.18|P-value:3.91E-4 ID:SGTC_2958|Compound:9077254|FD-Score:6.18|P-value:3.75E-11 ID:SGTC_3075|Compound:9116269|FD-Score:-3.91|P-value:2.06E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.36|P-value:1.95E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.17|P-value:4.07E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.76|P-value:4.10E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.40|P-value:1.84E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-7.05|P-value:6.86E-14 ID:SGTC_3216|Compound:9129716|FD-Score:3.67|P-value:5.53E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-6.61|P-value:2.01E-12 ID:SGTC_3246|Compound:9135460|FD-Score:-3.69|P-value:5.56E-5 ID:SGTC_3247|Compound:9135149|FD-Score:4.79|P-value:2.24E-7 ID:SGTC_3254|Compound:9136651|FD-Score:-4.05|P-value:1.10E-5 ID:SGTC_3257|Compound:9139206|FD-Score:-3.44|P-value:1.55E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.21|P-value:1.59E-14 ID:SGTC_3321|Compound:9137793|FD-Score:9.01|P-value:1.30E-21 ID:SGTC_3329|Compound:9141233|FD-Score:-3.33|P-value:2.48E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.89|P-value:2.07E-5

Top fitness defect scores for YNL022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3321 9137793 9.01 26.8 µM 1.30E-21 cell wall 8 1.08E-19
2 SGTC_3311 9131146 7.21 2.9 µM 1.59E-14 cell wall 43 2.82E-13
3 SGTC_2958 9077254 6.18 16.7 µM 3.75E-11 7 3.18E-10
4 SGTC_923 1900-2434 5.96 73.3 µM 1.67E-10 RNA processing & uracil transport 9 1.23E-9
5 SGTC_2584 androsterone 5.40 48.7 µM 6.31E-9 cell wall 69 3.30E-8
6 SGTC_3247 9135149 4.79 49.5 µM 2.24E-7 DNA damage response 17 8.35E-7
7 SGTC_358 0075-0058 4.62 9.4 µM 5.61E-7 36 1.92E-6
8 SGTC_1211 1056-0033 4.61 32.3 µM 5.91E-7 4 2.01E-6
9 SGTC_666 0272-0154 4.03 136.0 µM 1.06E-5 cell wall 53 2.76E-5
10 SGTC_3350 9150499 3.89 3.6 µM 2.07E-5 cell wall 55 5.06E-5
11 SGTC_1077 5-fluorocytosine 3.86 377.0 nM 2.40E-5 exosome 17 5.78E-5
12 SGTC_690 glyoxal 3.78 20.3 µM 3.37E-5 91 7.89E-5
13 SGTC_2896 9052656 3.74 71.4 µM 3.91E-5 endomembrane recycling 132 9.02E-5
14 SGTC_3216 9129716 3.67 49.5 µM 5.53E-5 RPP1 & pyrimidine depletion 31 1.23E-4
15 SGTC_934 2950-0684 3.64 338.0 µM 6.22E-5 28 1.37E-4
16 SGTC_1087 pterostilbene 3.59 9.1 µM 7.50E-5 37 1.63E-4
17 SGTC_1905 st060207 3.54 84.5 µM 9.28E-5 18 1.97E-4
18 SGTC_377 3970-0964 3.44 33.1 µM 1.41E-4 69 2.89E-4
19 SGTC_2322 7413319 3.39 38.2 µM 1.75E-4 ERAD & cell cycle 197 3.51E-4
20 SGTC_3098 9119039 3.36 49.5 µM 1.95E-4 Golgi 56 3.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 1.50E-42 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.218 1.89E-37 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.206 1.71E-33 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.205 3.13E-33 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.204 9.75E-33 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.199 2.50E-31 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.195 3.29E-30 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.192 2.97E-29 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.188 6.01E-28 YKR006C MRPL13 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.187 6.55E-28 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.181 3.31E-26 YMR275C BUL1 hom Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication
0.180 8.23E-26 YDR253C MET32 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
0.176 1.18E-24 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.175 1.32E-24 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.175 1.65E-24 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly