YNL024C_p

Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL024C / YNL024C

Click on Significant Values for Screen Details ID:SGTC_356|Compound:1634-0012|FD-Score:-3.47|P-value:2.56E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.36|P-value:6.71E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.20|P-value:7.06E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.24|P-value:6.19E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.06|P-value:2.52E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-3.52|P-value:2.13E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.34|P-value:4.31E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.11|P-value:9.64E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.30|P-value:5.02E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.39|P-value:3.55E-4 ID:SGTC_1940|Compound:st075990|FD-Score:6.76|P-value:7.64E-12 ID:SGTC_1953|Compound:st076800|FD-Score:3.39|P-value:3.62E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-3.22|P-value:6.42E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.64|P-value:1.33E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.22|P-value:6.34E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.51|P-value:2.32E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.47|P-value:2.65E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.45|P-value:2.75E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.25|P-value:5.84E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.47|P-value:2.56E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.36|P-value:6.71E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.20|P-value:7.06E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.24|P-value:6.19E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.06|P-value:2.52E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-3.52|P-value:2.13E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.34|P-value:4.31E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.11|P-value:9.64E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.30|P-value:5.02E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.39|P-value:3.55E-4 ID:SGTC_1940|Compound:st075990|FD-Score:6.76|P-value:7.64E-12 ID:SGTC_1953|Compound:st076800|FD-Score:3.39|P-value:3.62E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-3.22|P-value:6.42E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.64|P-value:1.33E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.22|P-value:6.34E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.51|P-value:2.32E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.47|P-value:2.65E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.45|P-value:2.75E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.25|P-value:5.84E-4

Top fitness defect scores for YNL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1940 st075990 6.76 51.1 µM 7.64E-12 60S ribosome export 1 7.05E-12
2 SGTC_417 st075190 4.36 100.0 µM 6.71E-6 3 6.44E-6
3 SGTC_1130 3454-2858 4.06 15.9 µM 2.52E-5 NEO1 85 2.42E-5
4 SGTC_906 1165-0455 3.67 526.0 µM 1.27E-4 17 1.23E-4
5 SGTC_2419 paclitaxel 3.51 166.5 µM 2.32E-4 66 2.25E-4
6 SGTC_2750 bromebric acid 3.47 70.2 µM 2.65E-4 50 2.57E-4
7 SGTC_1953 st076800 3.39 12.1 µM 3.62E-4 69 3.51E-4
8 SGTC_2408 sulbentine 3.37 18.4 µM 3.93E-4 69 3.82E-4
9 SGTC_1675 st018485 3.34 24.5 µM 4.31E-4 60S ribosome export 53 4.19E-4
10 SGTC_1906 st060206 3.30 94.7 µM 5.02E-4 39 4.88E-4
11 SGTC_880 0833-0487 3.24 87.2 µM 6.19E-4 mitochondrial processes 31 6.02E-4
12 SGTC_418 lividomycin a 3.20 100.0 µM 7.06E-4 34 6.87E-4
13 SGTC_1879 gemcitabine 3.11 100.0 µM 9.64E-4 52 9.39E-4
14 SGTC_489 paxilline 3.09 115.0 µM 0.00101 PDR1 52 9.86E-4
15 SGTC_1895 st058434 3.06 18.3 µM 0.00114 44 0.00111
16 SGTC_2470 5664817 3.04 21.7 µM 0.00123 39 0.00120
17 SGTC_3309 9129340 3.03 25.8 µM 0.00126 54 0.00123
18 SGTC_402 epigallocatechin gallate 3.02 10.0 µM 0.00128 79 0.00125
19 SGTC_2904 7225135 3.02 42.0 µM 0.00131 26 0.00128
20 SGTC_1925 st057770 3.01 10.1 µM 0.00134 TSC3-RPN4 54 0.00130

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.23E-21 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.125 3.93E-13 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.121 2.27E-12 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.107 6.16E-10 YOR013W_d IRC11_d hom Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
0.104 1.65E-9 YOL024W_p YOL024W_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.102 3.08E-9 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.102 3.29E-9 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.100 6.59E-9 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.098 1.37E-8 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.65E-8 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.096 2.87E-8 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.095 3.11E-8 YHR114W BZZ1 hom SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
0.094 5.22E-8 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.091 1.35E-7 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.088 3.63E-7 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data