YNL034W_p

Putative protein of unknown function; YNL034W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL034W / YNL034W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.18|P-value:4.19E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:6.07|P-value:8.52E-11 ID:SGTC_27|Compound:0485-0001|FD-Score:2.99|P-value:8.47E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.19|P-value:4.13E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.76|P-value:3.96E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:2.96|P-value:9.61E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-2.94|P-value:9.03E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.16|P-value:4.08E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.34|P-value:2.27E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.37|P-value:2.06E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.16|P-value:4.62E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:2.96|P-value:9.68E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.02|P-value:7.65E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.02|P-value:7.54E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.98|P-value:1.47E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.54|P-value:1.03E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.11|P-value:7.73E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.04|P-value:7.20E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.14|P-value:6.83E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.09|P-value:5.21E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.32|P-value:2.33E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.02|P-value:6.88E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.45|P-value:1.46E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.47|P-value:1.33E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.54|P-value:2.84E-9 ID:SGTC_1925|Compound:st057770|FD-Score:3.70|P-value:5.09E-5 ID:SGTC_1932|Compound:st074806|FD-Score:-3.01|P-value:6.99E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.18|P-value:3.78E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.12|P-value:4.64E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.28|P-value:2.84E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.36|P-value:2.09E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.24|P-value:3.31E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.31|P-value:2.26E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.73|P-value:4.52E-5 ID:SGTC_2482|Compound:5981709|FD-Score:5.25|P-value:1.64E-8 ID:SGTC_2557|Compound:derrustone|FD-Score:3.17|P-value:4.38E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.08|P-value:5.39E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.07|P-value:6.37E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:8.15|P-value:4.74E-18 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.22|P-value:3.70E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.25|P-value:2.82E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.46|P-value:1.40E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.15|P-value:4.82E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.92|P-value:1.88E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-3.55|P-value:8.42E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.08|P-value:6.09E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.10|P-value:5.74E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.23|P-value:3.52E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.67|P-value:4.97E-5 ID:SGTC_3209|Compound:9113616|FD-Score:4.18|P-value:5.51E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.18|P-value:4.19E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:6.07|P-value:8.52E-11 ID:SGTC_27|Compound:0485-0001|FD-Score:2.99|P-value:8.47E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.19|P-value:4.13E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.76|P-value:3.96E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:2.96|P-value:9.61E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-2.94|P-value:9.03E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.16|P-value:4.08E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.34|P-value:2.27E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.37|P-value:2.06E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.16|P-value:4.62E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:2.96|P-value:9.68E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.02|P-value:7.65E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.02|P-value:7.54E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.98|P-value:1.47E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.54|P-value:1.03E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.11|P-value:7.73E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.04|P-value:7.20E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.14|P-value:6.83E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.09|P-value:5.21E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.32|P-value:2.33E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.02|P-value:6.88E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.45|P-value:1.46E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.47|P-value:1.33E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.54|P-value:2.84E-9 ID:SGTC_1925|Compound:st057770|FD-Score:3.70|P-value:5.09E-5 ID:SGTC_1932|Compound:st074806|FD-Score:-3.01|P-value:6.99E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.18|P-value:3.78E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.12|P-value:4.64E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.28|P-value:2.84E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.36|P-value:2.09E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.24|P-value:3.31E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.31|P-value:2.26E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.73|P-value:4.52E-5 ID:SGTC_2482|Compound:5981709|FD-Score:5.25|P-value:1.64E-8 ID:SGTC_2557|Compound:derrustone|FD-Score:3.17|P-value:4.38E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.08|P-value:5.39E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.07|P-value:6.37E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:8.15|P-value:4.74E-18 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.22|P-value:3.70E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.25|P-value:2.82E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.46|P-value:1.40E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.15|P-value:4.82E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.92|P-value:1.88E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-3.55|P-value:8.42E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.08|P-value:6.09E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.10|P-value:5.74E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.23|P-value:3.52E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.67|P-value:4.97E-5 ID:SGTC_3209|Compound:9113616|FD-Score:4.18|P-value:5.51E-6

Top fitness defect scores for YNL034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2604 4'-hydroxychalcone 8.15 11.3 µM 4.74E-18 1 1.82E-16
2 SGTC_20 0481-0013 6.07 4.9 µM 8.52E-11 3 6.39E-10
3 SGTC_1923 st058458 5.54 19.1 µM 2.84E-9 9 1.52E-8
4 SGTC_2482 5981709 5.25 142.7 µM 1.64E-8 PDR1 18 7.42E-8
5 SGTC_3209 9113616 4.18 49.5 µM 5.51E-6 21 1.43E-5
6 SGTC_1256 0570-0116 4.14 285.0 µM 6.83E-6 15 1.74E-5
7 SGTC_1156 4092-0367 4.11 4.9 µM 7.73E-6 16 1.95E-5
8 SGTC_1031 k035-0009 3.98 16.0 µM 1.47E-5 30 3.49E-5
9 SGTC_2985 9022375 3.92 71.4 µM 1.88E-5 RPP1 & pyrimidine depletion 30 4.36E-5
10 SGTC_87 0100-0052 3.76 35.5 µM 3.96E-5 121 8.56E-5
11 SGTC_2419 paclitaxel 3.73 166.5 µM 4.52E-5 52 9.65E-5
12 SGTC_1925 st057770 3.70 10.1 µM 5.09E-5 TSC3-RPN4 25 1.07E-4
13 SGTC_1146 3579-1023 3.54 7.0 µM 1.03E-4 26 2.03E-4
14 SGTC_1603 st002045 3.47 67.8 µM 1.33E-4 TSC3-RPN4 30 2.58E-4
15 SGTC_2877 9040724 3.46 71.4 µM 1.40E-4 28 2.69E-4
16 SGTC_1602 st001878 3.45 87.6 µM 1.46E-4 37 2.80E-4
17 SGTC_348 k064-0012 3.37 10.7 µM 2.06E-4 60S ribosome export 34 3.82E-4
18 SGTC_2049 5262831 3.36 67.2 µM 2.09E-4 54 3.87E-4
19 SGTC_323 4013-0906 3.34 34.3 µM 2.27E-4 ERG2 21 4.18E-4
20 SGTC_1992 st073643 3.28 23.3 µM 2.84E-4 mitochondrial processes 25 5.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 1.85E-36 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.127 1.80E-13 YBR054W YRO2 hom Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication
0.116 1.99E-11 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.107 4.60E-10 YBL107C MIC23 hom Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)
0.100 6.15E-9 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.088 3.25E-7 YML058W-A HUG1 hom Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress
0.088 3.51E-7 YDL103C QRI1 het UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
0.086 6.95E-7 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.085 8.53E-7 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.083 1.30E-6 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.083 1.59E-6 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.082 1.90E-6 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.082 2.04E-6 YGR286C BIO2 hom Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.081 2.70E-6 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.47E-6 YGL078C DBP3 hom RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype