YNL038W / GPI15

Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL038W / GPI15

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-3.74|P-value:3.05E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.25|P-value:2.51E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.00|P-value:6.48E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.21|P-value:2.86E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.02|P-value:8.26E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:2.90|P-value:9.48E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.53|P-value:7.70E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.47|P-value:9.95E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.47|P-value:9.75E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.04|P-value:5.66E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.66|P-value:4.30E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.00|P-value:6.46E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.64|P-value:4.69E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.50|P-value:8.87E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.04|P-value:7.37E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:2.92|P-value:8.80E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.98|P-value:6.92E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.11|P-value:4.24E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.60|P-value:4.01E-7 ID:SGTC_2136|Compound:5328288|FD-Score:-3.85|P-value:1.84E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.78|P-value:2.52E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-4.51|P-value:6.56E-7 ID:SGTC_2348|Compound:9022543|FD-Score:3.34|P-value:1.71E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-4.30|P-value:2.00E-6 ID:SGTC_2397|Compound:5161689|FD-Score:-2.92|P-value:8.55E-4 ID:SGTC_2402|Compound:5553605|FD-Score:2.89|P-value:9.69E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.03|P-value:5.84E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.04|P-value:7.48E-6 ID:SGTC_2819|Compound:7996655|FD-Score:3.87|P-value:1.70E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.34|P-value:1.70E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.50|P-value:8.78E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.14|P-value:3.75E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.44|P-value:9.72E-7 ID:SGTC_3177|Compound:9107506|FD-Score:3.06|P-value:5.11E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.21|P-value:2.86E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.25|P-value:2.48E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.01|P-value:6.25E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.65|P-value:4.50E-5 ID:SGTC_3224|Compound:9130643|FD-Score:4.05|P-value:7.13E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.74|P-value:3.05E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.25|P-value:2.51E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.00|P-value:6.48E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.21|P-value:2.86E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.02|P-value:8.26E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:2.90|P-value:9.48E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.53|P-value:7.70E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.47|P-value:9.95E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.47|P-value:9.75E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.04|P-value:5.66E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.66|P-value:4.30E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.00|P-value:6.46E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.64|P-value:4.69E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.50|P-value:8.87E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.04|P-value:7.37E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:2.92|P-value:8.80E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.98|P-value:6.92E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.11|P-value:4.24E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.60|P-value:4.01E-7 ID:SGTC_2136|Compound:5328288|FD-Score:-3.85|P-value:1.84E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.78|P-value:2.52E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-4.51|P-value:6.56E-7 ID:SGTC_2348|Compound:9022543|FD-Score:3.34|P-value:1.71E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-4.30|P-value:2.00E-6 ID:SGTC_2397|Compound:5161689|FD-Score:-2.92|P-value:8.55E-4 ID:SGTC_2402|Compound:5553605|FD-Score:2.89|P-value:9.69E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.03|P-value:5.84E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.04|P-value:7.48E-6 ID:SGTC_2819|Compound:7996655|FD-Score:3.87|P-value:1.70E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.34|P-value:1.70E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.50|P-value:8.78E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.14|P-value:3.75E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.44|P-value:9.72E-7 ID:SGTC_3177|Compound:9107506|FD-Score:3.06|P-value:5.11E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.21|P-value:2.86E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.25|P-value:2.48E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.01|P-value:6.25E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.65|P-value:4.50E-5 ID:SGTC_3224|Compound:9130643|FD-Score:4.05|P-value:7.13E-6

Top fitness defect scores for YNL038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1908 st060353 4.60 56.5 µM 4.01E-7 RPP1 & pyrimidine depletion 7 2.08E-6 0.03
2 SGTC_3157 9099274 4.44 49.5 µM 9.72E-7 4 4.52E-6 0.60
3 SGTC_3224 9130643 4.05 49.5 µM 7.13E-6 RPP1 & pyrimidine depletion 7 2.58E-5 0.00
4 SGTC_1562 morin hydrate 4.04 59.1 µM 7.37E-6 7 2.66E-5 0.11
5 SGTC_2620 irigenin 4.04 100.0 µM 7.48E-6 13 2.69E-5 0.05
6 SGTC_431 k089-0097 4.02 107.0 µM 8.26E-6 iron homeostasis 15 2.94E-5 0.12
7 SGTC_2819 7996655 3.87 46.4 µM 1.70E-5 4 5.54E-5 0.16
8 SGTC_2177 5811945 3.78 192.0 µM 2.52E-5 4 7.81E-5 0.32
9 SGTC_953 1188-0045 3.66 9.7 µM 4.30E-5 60S ribosome export 9 1.25E-4 0.15
10 SGTC_3214 9129694 3.65 49.5 µM 4.50E-5 8 1.30E-4 0.00
11 SGTC_747 3448-8087 3.53 38.7 µM 7.70E-5 11 2.08E-4 0.29
12 SGTC_2877 9040724 3.50 71.4 µM 8.78E-5 4 2.33E-4 0.13
13 SGTC_1558 st069300 3.50 45.6 µM 8.87E-5 4 2.35E-4 0.26
14 SGTC_809 3998-0021 3.47 90.0 µM 9.75E-5 RNA processing & uracil transport 13 2.55E-4 0.12
15 SGTC_787 4152-0075 3.47 138.0 µM 9.95E-5 8 2.60E-4 0.13
16 SGTC_2348 9022543 3.34 33.4 µM 1.71E-4 mitochondrial processes 45 4.17E-4 0.01
17 SGTC_3195 9113082 3.25 49.5 µM 2.48E-4 4 5.78E-4 0.43
18 SGTC_69 0096-0274 3.25 206.7 µM 2.51E-4 mitochondrial processes 49 5.86E-4 0.00
19 SGTC_3190 9110366 3.21 49.5 µM 2.86E-4 8 6.57E-4 0.02
20 SGTC_2981 9013952 3.14 39.0 µM 3.75E-4 19 8.33E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.27E-24 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.104 1.37E-9 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.104 1.36E-9 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.096 2.75E-8 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
0.093 6.89E-8 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.28E-7 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.091 1.30E-7 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.090 1.69E-7 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.089 2.41E-7 YIL102C_p YIL102C_p hom Putative protein of unknown function
0.087 3.87E-7 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.087 4.20E-7 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.086 5.25E-7 YKR055W RHO4 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
0.085 7.44E-7 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.083 1.29E-6 YOR135C_d IRC14_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci
0.080 3.14E-6 YDL051W LHP1 hom RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen