YNL041C / COG6

Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL041C / COG6

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:7.13|P-value:1.00E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.62|P-value:2.79E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.99|P-value:8.96E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.98|P-value:1.34E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:8.30|P-value:7.38E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.18|P-value:6.42E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:6.09|P-value:7.56E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:7.31|P-value:6.77E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:6.64|P-value:2.66E-4 ID:SGTC_263|Compound:alizarin|FD-Score:7.26|P-value:7.56E-5 ID:SGTC_271|Compound:rotenone|FD-Score:8.42|P-value:5.45E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.80|P-value:3.19E-13 ID:SGTC_342|Compound:k048-0088|FD-Score:6.50|P-value:3.52E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.86|P-value:0.00100 ID:SGTC_389|Compound:tpck|FD-Score:7.40|P-value:5.68E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.16|P-value:5.80E-4 ID:SGTC_470|Compound:aa-861|FD-Score:7.37|P-value:6.04E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:7.07|P-value:1.12E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-6.48|P-value:3.17E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:6.93|P-value:1.49E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:6.78|P-value:2.04E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:6.77|P-value:2.05E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:9.51|P-value:3.36E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:7.22|P-value:8.32E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:7.60|P-value:3.68E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:8.91|P-value:1.64E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:10.50|P-value:2.02E-8 ID:SGTC_748|Compound:0136-0228|FD-Score:8.20|P-value:9.38E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:6.10|P-value:7.35E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:8.94|P-value:1.51E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-6.71|P-value:2.02E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:6.55|P-value:3.15E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:6.33|P-value:4.78E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.33|P-value:6.89E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:6.19|P-value:6.27E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:8.98|P-value:1.37E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.94|P-value:9.76E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:6.80|P-value:1.96E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:14.10|P-value:7.18E-14 ID:SGTC_1078|Compound:idebenone|FD-Score:6.18|P-value:6.36E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:8.78|P-value:2.28E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:7.50|P-value:4.52E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.78|P-value:2.26E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.53|P-value:3.30E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:8.06|P-value:1.29E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.10|P-value:1.05E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-7.81|P-value:1.92E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:10.40|P-value:2.46E-8 ID:SGTC_1633|Compound:st005664|FD-Score:6.38|P-value:4.43E-4 ID:SGTC_1732|Compound:st034308|FD-Score:6.24|P-value:5.72E-4 ID:SGTC_1735|Compound:st034310|FD-Score:6.42|P-value:4.08E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-6.11|P-value:6.31E-4 ID:SGTC_1775|Compound:st081588|FD-Score:6.15|P-value:6.77E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-6.54|P-value:2.82E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-6.00|P-value:7.74E-4 ID:SGTC_1915|Compound:st067105|FD-Score:8.38|P-value:6.08E-6 ID:SGTC_1917|Compound:st066507|FD-Score:9.61|P-value:2.55E-7 ID:SGTC_1919|Compound:st067113|FD-Score:-7.65|P-value:2.78E-5 ID:SGTC_1985|Compound:st071382|FD-Score:7.47|P-value:4.89E-5 ID:SGTC_2041|Compound:5107442|FD-Score:8.79|P-value:2.20E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-6.79|P-value:1.74E-4 ID:SGTC_2242|Compound:6630449|FD-Score:6.23|P-value:5.84E-4 ID:SGTC_2295|Compound:7971645|FD-Score:8.86|P-value:1.83E-6 ID:SGTC_2302|Compound:7771753|FD-Score:6.62|P-value:2.75E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-7.26|P-value:6.58E-5 ID:SGTC_2332|Compound:7982454|FD-Score:7.16|P-value:9.30E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:6.15|P-value:6.73E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:7.07|P-value:1.12E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:8.09|P-value:1.19E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:6.22|P-value:5.87E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.12|P-value:7.13E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:12.40|P-value:5.33E-11 ID:SGTC_2740|Compound:felodipine|FD-Score:6.10|P-value:7.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.91|P-value:1.58E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:7.58|P-value:3.80E-5 ID:SGTC_2781|Compound:5567276|FD-Score:9.87|P-value:1.26E-7 ID:SGTC_2790|Compound:5423970|FD-Score:-7.14|P-value:8.48E-5 ID:SGTC_2976|Compound:9009005|FD-Score:-6.08|P-value:6.67E-4 ID:SGTC_2981|Compound:9013952|FD-Score:7.66|P-value:3.16E-5 ID:SGTC_3004|Compound:9076122|FD-Score:6.94|P-value:1.48E-4 ID:SGTC_3009|Compound:9080819|FD-Score:6.20|P-value:6.13E-4 ID:SGTC_3057|Compound:9095946|FD-Score:5.98|P-value:9.20E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-6.05|P-value:7.06E-4 ID:SGTC_3166|Compound:9102297|FD-Score:8.47|P-value:4.90E-6 ID:SGTC_3277|Compound:9138724|FD-Score:9.74|P-value:1.81E-7 ID:SGTC_4|Compound:0960-0234|FD-Score:7.13|P-value:1.00E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.62|P-value:2.79E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.99|P-value:8.96E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.98|P-value:1.34E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:8.30|P-value:7.38E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.18|P-value:6.42E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:6.09|P-value:7.56E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:7.31|P-value:6.77E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:6.64|P-value:2.66E-4 ID:SGTC_263|Compound:alizarin|FD-Score:7.26|P-value:7.56E-5 ID:SGTC_271|Compound:rotenone|FD-Score:8.42|P-value:5.45E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.80|P-value:3.19E-13 ID:SGTC_342|Compound:k048-0088|FD-Score:6.50|P-value:3.52E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.86|P-value:0.00100 ID:SGTC_389|Compound:tpck|FD-Score:7.40|P-value:5.68E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.16|P-value:5.80E-4 ID:SGTC_470|Compound:aa-861|FD-Score:7.37|P-value:6.04E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:7.07|P-value:1.12E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-6.48|P-value:3.17E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:6.93|P-value:1.49E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:6.78|P-value:2.04E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:6.77|P-value:2.05E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:9.51|P-value:3.36E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:7.22|P-value:8.32E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:7.60|P-value:3.68E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:8.91|P-value:1.64E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:10.50|P-value:2.02E-8 ID:SGTC_748|Compound:0136-0228|FD-Score:8.20|P-value:9.38E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:6.10|P-value:7.35E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:8.94|P-value:1.51E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-6.71|P-value:2.02E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:6.55|P-value:3.15E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:6.33|P-value:4.78E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.33|P-value:6.89E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:6.19|P-value:6.27E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:8.98|P-value:1.37E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.94|P-value:9.76E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:6.80|P-value:1.96E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:14.10|P-value:7.18E-14 ID:SGTC_1078|Compound:idebenone|FD-Score:6.18|P-value:6.36E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:8.78|P-value:2.28E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:7.50|P-value:4.52E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.78|P-value:2.26E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.53|P-value:3.30E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:8.06|P-value:1.29E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.10|P-value:1.05E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-7.81|P-value:1.92E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:10.40|P-value:2.46E-8 ID:SGTC_1633|Compound:st005664|FD-Score:6.38|P-value:4.43E-4 ID:SGTC_1732|Compound:st034308|FD-Score:6.24|P-value:5.72E-4 ID:SGTC_1735|Compound:st034310|FD-Score:6.42|P-value:4.08E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-6.11|P-value:6.31E-4 ID:SGTC_1775|Compound:st081588|FD-Score:6.15|P-value:6.77E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-6.54|P-value:2.82E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-6.00|P-value:7.74E-4 ID:SGTC_1915|Compound:st067105|FD-Score:8.38|P-value:6.08E-6 ID:SGTC_1917|Compound:st066507|FD-Score:9.61|P-value:2.55E-7 ID:SGTC_1919|Compound:st067113|FD-Score:-7.65|P-value:2.78E-5 ID:SGTC_1985|Compound:st071382|FD-Score:7.47|P-value:4.89E-5 ID:SGTC_2041|Compound:5107442|FD-Score:8.79|P-value:2.20E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-6.79|P-value:1.74E-4 ID:SGTC_2242|Compound:6630449|FD-Score:6.23|P-value:5.84E-4 ID:SGTC_2295|Compound:7971645|FD-Score:8.86|P-value:1.83E-6 ID:SGTC_2302|Compound:7771753|FD-Score:6.62|P-value:2.75E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-7.26|P-value:6.58E-5 ID:SGTC_2332|Compound:7982454|FD-Score:7.16|P-value:9.30E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:6.15|P-value:6.73E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:7.07|P-value:1.12E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:8.09|P-value:1.19E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:6.22|P-value:5.87E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.12|P-value:7.13E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:12.40|P-value:5.33E-11 ID:SGTC_2740|Compound:felodipine|FD-Score:6.10|P-value:7.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.91|P-value:1.58E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:7.58|P-value:3.80E-5 ID:SGTC_2781|Compound:5567276|FD-Score:9.87|P-value:1.26E-7 ID:SGTC_2790|Compound:5423970|FD-Score:-7.14|P-value:8.48E-5 ID:SGTC_2976|Compound:9009005|FD-Score:-6.08|P-value:6.67E-4 ID:SGTC_2981|Compound:9013952|FD-Score:7.66|P-value:3.16E-5 ID:SGTC_3004|Compound:9076122|FD-Score:6.94|P-value:1.48E-4 ID:SGTC_3009|Compound:9080819|FD-Score:6.20|P-value:6.13E-4 ID:SGTC_3057|Compound:9095946|FD-Score:5.98|P-value:9.20E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-6.05|P-value:7.06E-4 ID:SGTC_3166|Compound:9102297|FD-Score:8.47|P-value:4.90E-6 ID:SGTC_3277|Compound:9138724|FD-Score:9.74|P-value:1.81E-7

Top fitness defect scores for YNL041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1060 3448-7350 14.10 82.0 µM 7.18E-14 Golgi 4 1.16E-45
2 SGTC_275 trichlorophene 13.80 5.7 µM 3.19E-13 mitochondrial stress 13 2.50E-43
3 SGTC_2737 bleomycin 12.40 30.5 nM 5.33E-11 Golgi 7 2.43E-35
4 SGTC_746 1095-0025 10.50 46.6 µM 2.02E-8 RSC & ERG11 1 4.12E-26
5 SGTC_1581 himbacine 10.40 57.9 µM 2.46E-8 Golgi 5 8.41E-26
6 SGTC_2781 5567276 9.87 71.4 µM 1.26E-7 4 2.80E-23
7 SGTC_3277 9138724 9.74 49.5 µM 1.81E-7 Golgi 3 1.03E-22
8 SGTC_1917 st066507 9.61 28.5 µM 2.55E-7 Golgi 1 3.51E-22
9 SGTC_632 0781-2353 9.51 4.7 µM 3.36E-7 Golgi 3 9.28E-22
10 SGTC_999 4022-0066 8.98 22.7 µM 1.37E-6 Golgi 5 1.38E-19
11 SGTC_893 0958-0369 8.94 48.9 µM 1.51E-6 2 1.92E-19
12 SGTC_736 0958-0254 8.91 92.6 µM 1.64E-6 Golgi 1 2.62E-19
13 SGTC_2295 7971645 8.86 200.0 µM 1.83E-6 1 3.85E-19
14 SGTC_2041 5107442 8.79 45.3 µM 2.20E-6 RSC complex & mRNA processing 5 7.30E-19
15 SGTC_1306 1185-0270 8.78 9.0 µM 2.26E-6 Golgi 14 8.03E-19
16 SGTC_1162 k048-0130 8.78 20.1 µM 2.28E-6 Golgi 3 8.30E-19
17 SGTC_3166 9102297 8.47 49.5 µM 4.90E-6 Golgi 3 1.25E-17
18 SGTC_271 rotenone 8.42 740.0 µM 5.45E-6 1 1.83E-17
19 SGTC_1915 st067105 8.38 30.6 µM 6.08E-6 RNA pol III & RNase P/MRP 4 2.68E-17
20 SGTC_970 1315-0089 8.33 19.5 µM 6.89E-6 RSC & ERG11 2 4.17E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.528 2.24E-239 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.527 3.87E-239 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.396 4.06E-126 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.344 2.43E-93 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.327 5.05E-84 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.327 6.27E-84 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.317 6.83E-79 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.309 4.59E-75 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.304 1.90E-72 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.294 7.74E-68 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.279 8.04E-61 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.278 1.21E-60 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.250 4.61E-49 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.225 7.98E-40 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.224 3.18E-39 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role