HIPHOP chemogenomics database

YNL041C / COG6

Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL041C / COG6

Click on Significant Values for Screen Details

Top fitness defect scores for YNL041C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1060	3448-7350	14.10	82.0 µM	7.18E-14	Golgi	4	1.16E-45
2	SGTC_275	trichlorophene	13.80	5.7 µM	3.19E-13	mitochondrial stress	13	2.50E-43
3	SGTC_2737	bleomycin	12.40	30.5 nM	5.33E-11	Golgi	7	2.43E-35
4	SGTC_746	1095-0025	10.50	46.6 µM	2.02E-8	RSC & ERG11	1	4.12E-26
5	SGTC_1581	himbacine	10.40	57.9 µM	2.46E-8	Golgi	5	8.41E-26
6	SGTC_2781	5567276	9.87	71.4 µM	1.26E-7		4	2.80E-23
7	SGTC_3277	9138724	9.74	49.5 µM	1.81E-7	Golgi	3	1.03E-22
8	SGTC_1917	st066507	9.61	28.5 µM	2.55E-7	Golgi	1	3.51E-22
9	SGTC_632	0781-2353	9.51	4.7 µM	3.36E-7	Golgi	3	9.28E-22
10	SGTC_999	4022-0066	8.98	22.7 µM	1.37E-6	Golgi	5	1.38E-19
11	SGTC_893	0958-0369	8.94	48.9 µM	1.51E-6		2	1.92E-19
12	SGTC_736	0958-0254	8.91	92.6 µM	1.64E-6	Golgi	1	2.62E-19
13	SGTC_2295	7971645	8.86	200.0 µM	1.83E-6		1	3.85E-19
14	SGTC_2041	5107442	8.79	45.3 µM	2.20E-6	RSC complex & mRNA processing	5	7.30E-19
15	SGTC_1306	1185-0270	8.78	9.0 µM	2.26E-6	Golgi	14	8.03E-19
16	SGTC_1162	k048-0130	8.78	20.1 µM	2.28E-6	Golgi	3	8.30E-19
17	SGTC_3166	9102297	8.47	49.5 µM	4.90E-6	Golgi	3	1.25E-17
18	SGTC_271	rotenone	8.42	740.0 µM	5.45E-6		1	1.83E-17
19	SGTC_1915	st067105	8.38	30.6 µM	6.08E-6	RNA pol III & RNase P/MRP	4	2.68E-17
20	SGTC_970	1315-0089	8.33	19.5 µM	6.89E-6	RSC & ERG11	2	4.17E-17

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.528	2.24E-239	YGL005C	COG7	hom	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.527	3.87E-239	YML071C	COG8	hom	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.396	4.06E-126	YKR019C	IRS4	hom	EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.344	2.43E-93	YDR136C_d	VPS61_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.327	5.05E-84	YDR137W	RGP1	hom	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.327	6.27E-84	YNL051W	COG5	hom	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.317	6.83E-79	YJL004C	SYS1	hom	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.309	4.59E-75	YLR262C	YPT6	hom	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.304	1.90E-72	YLR261C_d	VPS63_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.294	7.74E-68	YLR039C	RIC1	hom	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.279	8.04E-61	YOL018C	TLG2	hom	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.278	1.21E-60	YBR164C	ARL1	hom	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.250	4.61E-49	YPL051W	ARL3	hom	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.225	7.98E-40	YDR320C	SWA2	hom	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.224	3.18E-39	YDR108W	TRS85	hom	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role