YNL045W / LAP2

Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL045W / LAP2

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.98|P-value:1.22E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.58|P-value:7.42E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.15|P-value:4.42E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.80|P-value:3.11E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:5.95|P-value:1.48E-10 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.20|P-value:3.78E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.68|P-value:5.28E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.16|P-value:4.37E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.96|P-value:1.37E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.10|P-value:5.08E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.95|P-value:9.41E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.51|P-value:9.96E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.45|P-value:1.22E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.02|P-value:1.14E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.08|P-value:5.44E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.54|P-value:9.47E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.01|P-value:6.98E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:2.97|P-value:8.33E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.39|P-value:1.76E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-4.66|P-value:4.35E-7 ID:SGTC_1724|Compound:st037281|FD-Score:-3.82|P-value:2.79E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.96|P-value:8.90E-4 ID:SGTC_1807|Compound:st050092|FD-Score:-2.97|P-value:8.82E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.02|P-value:7.25E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.60|P-value:6.77E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.05|P-value:6.54E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.14|P-value:4.62E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.98|P-value:1.22E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.28|P-value:2.73E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.00|P-value:7.38E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.75|P-value:3.90E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.58|P-value:7.41E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.55|P-value:9.07E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.15|P-value:4.20E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.09|P-value:5.18E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.78|P-value:3.41E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:2.93|P-value:9.30E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.11|P-value:5.23E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-5.01|P-value:6.20E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:10.00|P-value:1.58E-26 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.52|P-value:8.43E-7 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.65|P-value:6.05E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.63|P-value:6.38E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.00|P-value:7.80E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.50|P-value:1.05E-4 ID:SGTC_2879|Compound:9041815|FD-Score:2.98|P-value:7.86E-4 ID:SGTC_2884|Compound:9058502|FD-Score:2.96|P-value:8.43E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.98|P-value:6.68E-8 ID:SGTC_2924|Compound:9010168|FD-Score:-3.19|P-value:3.81E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.74|P-value:3.63E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.99|P-value:1.16E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.57|P-value:7.58E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.06|P-value:6.36E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.98|P-value:1.22E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.58|P-value:7.42E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.15|P-value:4.42E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.80|P-value:3.11E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:5.95|P-value:1.48E-10 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.20|P-value:3.78E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.68|P-value:5.28E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.16|P-value:4.37E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.96|P-value:1.37E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.10|P-value:5.08E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.95|P-value:9.41E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.51|P-value:9.96E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.45|P-value:1.22E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.02|P-value:1.14E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.08|P-value:5.44E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.54|P-value:9.47E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.01|P-value:6.98E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:2.97|P-value:8.33E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.39|P-value:1.76E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-4.66|P-value:4.35E-7 ID:SGTC_1724|Compound:st037281|FD-Score:-3.82|P-value:2.79E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.96|P-value:8.90E-4 ID:SGTC_1807|Compound:st050092|FD-Score:-2.97|P-value:8.82E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.02|P-value:7.25E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.60|P-value:6.77E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.05|P-value:6.54E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.14|P-value:4.62E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.98|P-value:1.22E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.28|P-value:2.73E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.00|P-value:7.38E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.75|P-value:3.90E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.58|P-value:7.41E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.55|P-value:9.07E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.15|P-value:4.20E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.09|P-value:5.18E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.78|P-value:3.41E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:2.93|P-value:9.30E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.11|P-value:5.23E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-5.01|P-value:6.20E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:10.00|P-value:1.58E-26 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.52|P-value:8.43E-7 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.65|P-value:6.05E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.63|P-value:6.38E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.00|P-value:7.80E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.50|P-value:1.05E-4 ID:SGTC_2879|Compound:9041815|FD-Score:2.98|P-value:7.86E-4 ID:SGTC_2884|Compound:9058502|FD-Score:2.96|P-value:8.43E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.98|P-value:6.68E-8 ID:SGTC_2924|Compound:9010168|FD-Score:-3.19|P-value:3.81E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.74|P-value:3.63E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.99|P-value:1.16E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.57|P-value:7.58E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.06|P-value:6.36E-4

Top fitness defect scores for YNL045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 10.00 100.0 µM 1.58E-26 4 6.71E-24
2 SGTC_287 k060-0039 5.95 29.6 µM 1.48E-10 1 1.33E-9
3 SGTC_2919 7978188 4.98 46.4 µM 6.68E-8 9 3.18E-7
4 SGTC_2634 4'-methoxyflavone 4.52 100.0 µM 8.43E-7 21 3.09E-6
5 SGTC_1176 0848-0131 4.45 83.3 µM 1.22E-6 Golgi 15 4.30E-6
6 SGTC_3154 9100113 3.99 49.5 µM 1.16E-5 27 3.24E-5
7 SGTC_2255 7941087 3.98 197.4 µM 1.22E-5 30 3.40E-5
8 SGTC_53 0973-0023 3.98 40.0 µM 1.22E-5 RNA processing & uracil transport 16 3.41E-5
9 SGTC_537 1334-0398 3.96 209.0 µM 1.37E-5 24 3.78E-5
10 SGTC_2940 9060638 3.74 45.9 µM 3.63E-5 amide catabolism 33 9.05E-5
11 SGTC_2014 4013930 3.60 200.0 µM 6.77E-5 54 1.58E-4
12 SGTC_2411 st077133 3.58 39.9 µM 7.41E-5 RNA pol III & RNase P/MRP 42 1.72E-4
13 SGTC_70 0141-0289 3.58 43.3 µM 7.42E-5 mitochondrial stress 207 1.72E-4
14 SGTC_3341 9147222 3.57 25.9 µM 7.58E-5 RNA processing & uracil transport 23 1.75E-4
15 SGTC_1134 3477-0009 3.51 42.5 µM 9.96E-5 62 2.24E-4
16 SGTC_2877 9040724 3.50 71.4 µM 1.05E-4 24 2.35E-4
17 SGTC_780 0109-0199 3.48 192.0 µM 1.15E-4 34 2.55E-4
18 SGTC_2684 capsaicin 3.29 100.0 µM 2.40E-4 36 4.95E-4
19 SGTC_2431 5490079 3.15 200.0 µM 4.20E-4 74 8.17E-4
20 SGTC_635 k038-0028 3.10 24.7 µM 5.08E-4 ubiquinone biosynthesis & proteasome 89 9.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 9.20E-26 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.180 9.83E-26 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.176 1.21E-24 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.169 4.89E-23 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.151 1.36E-18 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.133 1.27E-14 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.132 1.38E-14 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.129 6.00E-14 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.121 1.98E-12 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.118 7.20E-12 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.115 2.78E-11 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.113 4.57E-11 YOL094C RFC4 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.110 1.44E-10 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.107 5.73E-10 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.107 5.97E-10 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol