Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YNL045W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.180 | 9.20E-26 | YKL116C | PRR1 | hom | Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor |
0.180 | 9.83E-26 | YNR003C | RPC34 | het | RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex |
0.176 | 1.21E-24 | YDR104C | SPO71 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains |
0.169 | 4.89E-23 | YLR179C | YLR179C | hom | Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus |
0.151 | 1.36E-18 | YPL263C | KEL3 | hom | Cytoplasmic protein of unknown function |
0.133 | 1.27E-14 | YDL239C | ADY3 | hom | Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication |
0.132 | 1.38E-14 | YER045C | ACA1 | hom | ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication |
0.129 | 6.00E-14 | YBL003C | HTA2 | hom | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
0.121 | 1.98E-12 | YLL063C | AYT1 | hom | Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis |
0.118 | 7.20E-12 | YPL258C | THI21 | hom | Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p |
0.115 | 2.78E-11 | YBR165W | UBS1 | hom | Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity |
0.113 | 4.57E-11 | YOL094C | RFC4 | het | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
0.110 | 1.44E-10 | YJL171C | YJL171C | hom | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
0.107 | 5.73E-10 | YIL046W-A_p | YIL046W-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
0.107 | 5.97E-10 | YDR521W_d | YDR521W_d | hom | Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol |