YNL050C_p

Putative protein of unknown function; YNL050c is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL050C / YNL050C

Click on Significant Values for Screen Details ID:SGTC_192|Compound:3455-0609|FD-Score:3.22|P-value:6.11E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.10|P-value:9.46E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.87|P-value:5.11E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.58|P-value:2.08E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.60|P-value:1.21E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.16|P-value:7.62E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.07|P-value:8.49E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.78|P-value:7.73E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.12|P-value:7.20E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.51|P-value:1.72E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.30|P-value:4.67E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.10|P-value:7.83E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.75|P-value:8.20E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.60|P-value:1.21E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.33|P-value:4.19E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.84|P-value:5.78E-5 ID:SGTC_1893|Compound:st059353|FD-Score:3.51|P-value:2.15E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.08|P-value:9.98E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.37|P-value:3.58E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.11|P-value:7.56E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.09|P-value:9.72E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.18|P-value:5.74E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.87|P-value:4.83E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-3.18|P-value:5.94E-4 ID:SGTC_2244|Compound:6635614|FD-Score:4.13|P-value:1.63E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.13|P-value:1.65E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.27|P-value:5.19E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.49|P-value:2.37E-6 ID:SGTC_2945|Compound:9067681|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.38|P-value:3.03E-8 ID:SGTC_2971|Compound:9092186|FD-Score:4.02|P-value:2.67E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.32|P-value:7.00E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.36|P-value:3.68E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.45|P-value:2.15E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.77|P-value:6.11E-5 ID:SGTC_3355|Compound:9151058|FD-Score:-3.14|P-value:6.79E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.22|P-value:6.11E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.10|P-value:9.46E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.87|P-value:5.11E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.58|P-value:2.08E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.60|P-value:1.21E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.16|P-value:7.62E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.07|P-value:8.49E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.78|P-value:7.73E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.12|P-value:7.20E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.51|P-value:1.72E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.30|P-value:4.67E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.10|P-value:7.83E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.75|P-value:8.20E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.60|P-value:1.21E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.33|P-value:4.19E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.84|P-value:5.78E-5 ID:SGTC_1893|Compound:st059353|FD-Score:3.51|P-value:2.15E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.08|P-value:9.98E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.37|P-value:3.58E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.11|P-value:7.56E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.09|P-value:9.72E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.18|P-value:5.74E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.87|P-value:4.83E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-3.18|P-value:5.94E-4 ID:SGTC_2244|Compound:6635614|FD-Score:4.13|P-value:1.63E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.13|P-value:1.65E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.27|P-value:5.19E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.49|P-value:2.37E-6 ID:SGTC_2945|Compound:9067681|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.38|P-value:3.03E-8 ID:SGTC_2971|Compound:9092186|FD-Score:4.02|P-value:2.67E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.32|P-value:7.00E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.36|P-value:3.68E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.45|P-value:2.15E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.77|P-value:6.11E-5 ID:SGTC_3355|Compound:9151058|FD-Score:-3.14|P-value:6.79E-4

Top fitness defect scores for YNL050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2954 9074818 5.38 52.7 µM 3.03E-8 15 3.73E-8
2 SGTC_2166 5933061 4.87 31.5 µM 4.83E-7 tubulin folding & SWR complex 21 5.66E-7
3 SGTC_972 1319-0219 4.78 195.0 µM 7.73E-7 8 8.98E-7
4 SGTC_464 bw-b 70c 4.58 158.0 µM 2.08E-6 11 2.37E-6
5 SGTC_3146 9095609 4.32 49.5 µM 7.00E-6 10 7.83E-6
6 SGTC_2244 6635614 4.13 200.0 µM 1.63E-5 4 1.80E-5
7 SGTC_2556 citropten 4.13 84.6 µM 1.65E-5 23 1.82E-5
8 SGTC_2971 9092186 4.02 9.9 µM 2.67E-5 ergosterol biosynthesis 31 2.92E-5
9 SGTC_436 n,n-dimethylsphingosine 3.87 3.3 µM 5.11E-5 31 5.52E-5
10 SGTC_1878 temozolomide 3.84 1.0 mM 5.78E-5 8 6.24E-5
11 SGTC_1212 0520-0165 3.75 585.0 µM 8.20E-5 39 8.80E-5
12 SGTC_2245 6637752 3.58 200.0 µM 1.62E-4 24 1.72E-4
13 SGTC_1893 st059353 3.51 36.1 µM 2.15E-4 40 2.27E-4
14 SGTC_1938 st074717 3.37 56.4 µM 3.58E-4 23 3.75E-4
15 SGTC_3147 9097027 3.36 49.5 µM 3.68E-4 47 3.86E-4
16 SGTC_2945 9067681 3.34 61.8 µM 4.07E-4 25 4.26E-4
17 SGTC_1286 0929-0070 3.33 131.0 µM 4.19E-4 41 4.38E-4
18 SGTC_1144 3486-0183 3.30 12.5 µM 4.67E-4 47 4.87E-4
19 SGTC_2591 skatole 3.27 100.0 µM 5.19E-4 47 5.41E-4
20 SGTC_192 3455-0609 3.22 60.9 µM 6.11E-4 40 6.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 8.65E-10 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.104 1.59E-9 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.094 5.68E-8 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.086 5.54E-7 YMR194C-B CMC4 hom Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs
0.086 5.92E-7 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.084 1.23E-6 YDR109C_p YDR109C_p hom Putative kinase
0.083 1.49E-6 YLR215C CDC123 het Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
0.083 1.54E-6 YMR012W CLU1 hom eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.082 1.96E-6 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.079 4.42E-6 YLL049W LDB18 hom Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
0.079 4.64E-6 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.079 5.12E-6 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.078 5.31E-6 YBR172C SMY2 hom Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication
0.078 5.38E-6 YHL021C AIM17 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.078 6.12E-6 YPR117W_p YPR117W_p hom Putative protein of unknown function