YNL051W / COG5

Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL051W / COG5

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:5.20|P-value:1.90E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:-4.86|P-value:4.60E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-4.81|P-value:5.20E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.61|P-value:8.48E-4 ID:SGTC_389|Compound:tpck|FD-Score:4.72|P-value:6.39E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:5.95|P-value:2.41E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.75|P-value:4.36E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-5.55|P-value:7.68E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-4.95|P-value:3.67E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-5.10|P-value:2.54E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-4.63|P-value:8.05E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:7.45|P-value:1.82E-7 ID:SGTC_643|Compound:k048-0106|FD-Score:6.19|P-value:1.17E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:5.93|P-value:2.57E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.22|P-value:1.81E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:7.59|P-value:1.09E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.83|P-value:3.51E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:-5.65|P-value:5.82E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.81|P-value:3.60E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:8.14|P-value:1.38E-8 ID:SGTC_959|Compound:1222-0044|FD-Score:6.37|P-value:6.91E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:7.29|P-value:3.18E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:8.32|P-value:6.81E-9 ID:SGTC_1055|Compound:3448-0672|FD-Score:-5.25|P-value:1.74E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-5.98|P-value:2.31E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:8.66|P-value:1.72E-9 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.88|P-value:2.98E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:11.30|P-value:6.05E-15 ID:SGTC_1238|Compound:0333-0287|FD-Score:6.72|P-value:2.25E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:5.77|P-value:4.06E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.78|P-value:4.01E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.72|P-value:2.27E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:5.99|P-value:2.15E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-6.74|P-value:2.18E-6 ID:SGTC_1752|Compound:st044819|FD-Score:-7.66|P-value:8.73E-8 ID:SGTC_1760|Compound:st045453|FD-Score:-4.80|P-value:5.37E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.69|P-value:5.20E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-6.05|P-value:1.84E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-8.25|P-value:9.12E-9 ID:SGTC_2134|Compound:5324836|FD-Score:-4.97|P-value:3.53E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.54|P-value:7.77E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.71|P-value:6.48E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.85|P-value:4.69E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.54|P-value:9.67E-4 ID:SGTC_2352|Compound:9027995|FD-Score:7.55|P-value:1.27E-7 ID:SGTC_2359|Compound:9039622|FD-Score:-5.93|P-value:2.68E-5 ID:SGTC_2460|Compound:5552655|FD-Score:7.42|P-value:2.00E-7 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.59|P-value:8.69E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.14|P-value:2.26E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-5.68|P-value:5.41E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-6.49|P-value:4.78E-6 ID:SGTC_2671|Compound:danthron|FD-Score:5.31|P-value:1.44E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.76|P-value:5.70E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-4.89|P-value:4.32E-4 ID:SGTC_2900|Compound:5328528|FD-Score:6.97|P-value:9.88E-7 ID:SGTC_2948|Compound:9070189|FD-Score:-5.05|P-value:2.87E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-4.76|P-value:5.90E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-7.43|P-value:2.03E-7 ID:SGTC_3310|Compound:9130229|FD-Score:5.83|P-value:3.43E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:5.20|P-value:1.90E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:-4.86|P-value:4.60E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-4.81|P-value:5.20E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.61|P-value:8.48E-4 ID:SGTC_389|Compound:tpck|FD-Score:4.72|P-value:6.39E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:5.95|P-value:2.41E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.75|P-value:4.36E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-5.55|P-value:7.68E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-4.95|P-value:3.67E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-5.10|P-value:2.54E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-4.63|P-value:8.05E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:7.45|P-value:1.82E-7 ID:SGTC_643|Compound:k048-0106|FD-Score:6.19|P-value:1.17E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:5.93|P-value:2.57E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.22|P-value:1.81E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:7.59|P-value:1.09E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.83|P-value:3.51E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:-5.65|P-value:5.82E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.81|P-value:3.60E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:8.14|P-value:1.38E-8 ID:SGTC_959|Compound:1222-0044|FD-Score:6.37|P-value:6.91E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:7.29|P-value:3.18E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:8.32|P-value:6.81E-9 ID:SGTC_1055|Compound:3448-0672|FD-Score:-5.25|P-value:1.74E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-5.98|P-value:2.31E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:8.66|P-value:1.72E-9 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.88|P-value:2.98E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:11.30|P-value:6.05E-15 ID:SGTC_1238|Compound:0333-0287|FD-Score:6.72|P-value:2.25E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:5.77|P-value:4.06E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.78|P-value:4.01E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.72|P-value:2.27E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:5.99|P-value:2.15E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-6.74|P-value:2.18E-6 ID:SGTC_1752|Compound:st044819|FD-Score:-7.66|P-value:8.73E-8 ID:SGTC_1760|Compound:st045453|FD-Score:-4.80|P-value:5.37E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.69|P-value:5.20E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-6.05|P-value:1.84E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-8.25|P-value:9.12E-9 ID:SGTC_2134|Compound:5324836|FD-Score:-4.97|P-value:3.53E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.54|P-value:7.77E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.71|P-value:6.48E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.85|P-value:4.69E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.54|P-value:9.67E-4 ID:SGTC_2352|Compound:9027995|FD-Score:7.55|P-value:1.27E-7 ID:SGTC_2359|Compound:9039622|FD-Score:-5.93|P-value:2.68E-5 ID:SGTC_2460|Compound:5552655|FD-Score:7.42|P-value:2.00E-7 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.59|P-value:8.69E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.14|P-value:2.26E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-5.68|P-value:5.41E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-6.49|P-value:4.78E-6 ID:SGTC_2671|Compound:danthron|FD-Score:5.31|P-value:1.44E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.76|P-value:5.70E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-4.89|P-value:4.32E-4 ID:SGTC_2900|Compound:5328528|FD-Score:6.97|P-value:9.88E-7 ID:SGTC_2948|Compound:9070189|FD-Score:-5.05|P-value:2.87E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-4.76|P-value:5.90E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-7.43|P-value:2.03E-7 ID:SGTC_3310|Compound:9130229|FD-Score:5.83|P-value:3.43E-5

Top fitness defect scores for YNL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1225 1216-0074 11.30 20.6 µM 6.05E-15 1 6.36E-30
2 SGTC_1162 k048-0130 8.66 20.1 µM 1.72E-9 Golgi 4 2.44E-18
3 SGTC_1034 k072-0165 8.32 12.7 µM 6.81E-9 Golgi 3 4.49E-17
4 SGTC_958 1222-0007 8.14 33.0 µM 1.38E-8 2 2.01E-16
5 SGTC_830 4076-0286 7.59 57.8 µM 1.09E-7 translation 3 1.58E-14
6 SGTC_2352 9027995 7.55 87.8 µM 1.27E-7 tubulin folding & SWR complex 6 2.16E-14
7 SGTC_632 0781-2353 7.45 4.7 µM 1.82E-7 Golgi 4 4.63E-14
8 SGTC_2460 5552655 7.42 174.2 µM 2.00E-7 amide catabolism 7 5.66E-14
9 SGTC_1029 k015-0030 7.29 64.7 µM 3.18E-7 2 1.50E-13
10 SGTC_2900 5328528 6.97 85.3 µM 9.88E-7 Golgi 7 1.63E-12
11 SGTC_1238 0333-0287 6.72 48.8 µM 2.25E-6 Golgi 1 9.25E-12
12 SGTC_1353 1498-1206 6.72 8.1 µM 2.27E-6 mitochondrial response to ROS 10 9.37E-12
13 SGTC_959 1222-0044 6.37 107.0 µM 6.91E-6 2 9.70E-11
14 SGTC_643 k048-0106 6.19 28.4 µM 1.17E-5 RSC & ERG11 1 2.92E-10
15 SGTC_1497 4476-2978 5.99 41.3 µM 2.15E-5 1 1.04E-9
16 SGTC_430 0958-0115 5.95 16.4 µM 2.41E-5 7 1.33E-9
17 SGTC_757 1066-0008 5.93 322.0 µM 2.57E-5 Golgi 5 1.51E-9
18 SGTC_1176 0848-0131 5.88 83.3 µM 2.98E-5 Golgi 3 2.07E-9
19 SGTC_3310 9130229 5.83 44.1 µM 3.43E-5 Golgi 5 2.77E-9
20 SGTC_878 0828-0289 5.81 13.7 µM 3.60E-5 15 3.06E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.377 1.35E-113 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.359 5.99E-102 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.356 2.23E-100 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.327 6.27E-84 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.322 2.35E-81 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.320 4.79E-80 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.303 8.42E-72 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.266 5.04E-55 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.261 2.34E-53 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.208 6.32E-34 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.198 4.59E-31 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.193 1.93E-29 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.169 5.79E-23 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.159 2.37E-20 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.156 1.41E-19 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p