YNL052W / COX5A

Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL052W / COX5A

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.24|P-value:2.24E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.03|P-value:5.41E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.74|P-value:2.60E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.21|P-value:2.57E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:4.48|P-value:6.26E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.02|P-value:5.45E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.50|P-value:7.23E-42 ID:SGTC_310|Compound:1273-0058|FD-Score:4.46|P-value:6.83E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:3.03|P-value:5.21E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.97|P-value:8.52E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.01|P-value:5.65E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.40|P-value:9.41E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:3.37|P-value:1.31E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.18|P-value:3.03E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.50|P-value:5.59E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.49|P-value:7.82E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.55|P-value:4.33E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:-2.88|P-value:9.49E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.57|P-value:5.83E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:2.94|P-value:7.22E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.95|P-value:9.68E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.72|P-value:2.88E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.00|P-value:5.86E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.05|P-value:4.72E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.21|P-value:2.60E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.10|P-value:3.94E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.67|P-value:3.51E-5 ID:SGTC_1659|Compound:st012954|FD-Score:-3.43|P-value:1.07E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.40|P-value:9.40E-7 ID:SGTC_1941|Compound:st076221|FD-Score:3.09|P-value:4.16E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.30|P-value:1.78E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-4.29|P-value:1.80E-6 ID:SGTC_1960|Compound:st011366|FD-Score:-3.14|P-value:3.43E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.13|P-value:3.69E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.39|P-value:1.22E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.76|P-value:2.39E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-4.64|P-value:2.70E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-4.08|P-value:5.26E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.62|P-value:4.38E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.92|P-value:1.11E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.99|P-value:6.21E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.00|P-value:6.02E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.10|P-value:4.03E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.01|P-value:5.87E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.89|P-value:8.66E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.11|P-value:3.88E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.08|P-value:4.19E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.14|P-value:3.41E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:5.51E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.01|P-value:5.55E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.03|P-value:5.39E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.24|P-value:2.24E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.03|P-value:5.41E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.74|P-value:2.60E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.21|P-value:2.57E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:4.48|P-value:6.26E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.02|P-value:5.45E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.50|P-value:7.23E-42 ID:SGTC_310|Compound:1273-0058|FD-Score:4.46|P-value:6.83E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:3.03|P-value:5.21E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.97|P-value:8.52E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.01|P-value:5.65E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.40|P-value:9.41E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:3.37|P-value:1.31E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.18|P-value:3.03E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.50|P-value:5.59E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.49|P-value:7.82E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.55|P-value:4.33E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:-2.88|P-value:9.49E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.57|P-value:5.83E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:2.94|P-value:7.22E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.95|P-value:9.68E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.72|P-value:2.88E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.00|P-value:5.86E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.05|P-value:4.72E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.21|P-value:2.60E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.10|P-value:3.94E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.67|P-value:3.51E-5 ID:SGTC_1659|Compound:st012954|FD-Score:-3.43|P-value:1.07E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.40|P-value:9.40E-7 ID:SGTC_1941|Compound:st076221|FD-Score:3.09|P-value:4.16E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.30|P-value:1.78E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-4.29|P-value:1.80E-6 ID:SGTC_1960|Compound:st011366|FD-Score:-3.14|P-value:3.43E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.13|P-value:3.69E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.39|P-value:1.22E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.76|P-value:2.39E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-4.64|P-value:2.70E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-4.08|P-value:5.26E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.62|P-value:4.38E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.92|P-value:1.11E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.99|P-value:6.21E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.00|P-value:6.02E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.10|P-value:4.03E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.01|P-value:5.87E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.89|P-value:8.66E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.11|P-value:3.88E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.08|P-value:4.19E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.14|P-value:3.41E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:5.51E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.01|P-value:5.55E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.03|P-value:5.39E-4

Top fitness defect scores for YNL052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.50 5.3 µM 7.23E-42 139 4.48E-36
2 SGTC_1230 0170-0365 4.55 3.8 µM 4.33E-7 endomembrane recycling 43 2.74E-6
3 SGTC_886 0866-0150 4.50 153.0 µM 5.59E-7 13 3.42E-6
4 SGTC_193 1273-0060 4.48 1.6 µM 6.26E-7 ergosterol biosynthesis 5 3.76E-6
5 SGTC_310 1273-0058 4.46 1.1 µM 6.83E-7 mitochondrial stress 214 4.06E-6
6 SGTC_1718 roemerine 4.40 11.9 µM 9.40E-7 redox potentiating 38 5.34E-6
7 SGTC_699 0375-0592 4.40 111.0 µM 9.41E-7 iron homeostasis 12 5.35E-6
8 SGTC_15 0266-0086 4.24 27.1 µM 2.24E-6 endomembrane recycling 50 1.13E-5
9 SGTC_1456 k015-0012 4.21 13.0 µM 2.60E-6 26 1.28E-5
10 SGTC_533 1222-0222 3.97 6.7 µM 8.52E-6 PDR1 28 3.56E-5
11 SGTC_1295 1013-0063 3.95 9.8 µM 9.68E-6 11 3.97E-5
12 SGTC_2407 paclitaxel 3.92 400.0 µM 1.11E-5 37 4.47E-5
13 SGTC_2021 4019055 3.76 173.0 µM 2.39E-5 endomembrane recycling 134 8.63E-5
14 SGTC_69 0096-0274 3.74 206.7 µM 2.60E-5 mitochondrial processes 50 9.30E-5
15 SGTC_1305 1181-0477 3.72 144.0 µM 2.88E-5 19 1.01E-4
16 SGTC_1635 st007035 3.67 42.4 µM 3.51E-5 228 1.20E-4
17 SGTC_2357 9067248 3.62 200.0 µM 4.38E-5 30 1.46E-4
18 SGTC_1034 k072-0165 3.49 12.7 µM 7.82E-5 Golgi 35 2.40E-4
19 SGTC_1972 st070201 3.39 17.4 µM 1.22E-4 41 3.52E-4
20 SGTC_829 1635-0120 3.37 117.0 µM 1.31E-4 DNA damage response 65 3.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.460 5.59E-175 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.435 1.44E-154 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.419 9.49E-143 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.407 3.00E-134 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.402 1.09E-130 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.387 2.12E-120 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.386 9.68E-120 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.374 1.17E-111 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.372 1.46E-110 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.369 9.87E-109 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.366 4.30E-107 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.365 2.15E-106 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.365 4.54E-106 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.364 1.01E-105 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.360 2.95E-103 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1