YNL054W / VAC7

Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL054W / VAC7

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:4.96|P-value:1.96E-7 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.61|P-value:9.16E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.88|P-value:2.95E-7 ID:SGTC_572|Compound:0960-0087|FD-Score:3.10|P-value:5.96E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:5.83|P-value:1.48E-9 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.55|P-value:4.49E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.70|P-value:6.41E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.59|P-value:9.79E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.69|P-value:6.77E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.70|P-value:2.57E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.89|P-value:2.94E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:5.43|P-value:1.55E-8 ID:SGTC_882|Compound:0843-0131|FD-Score:4.97|P-value:1.83E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.50|P-value:1.39E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.10|P-value:6.06E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.62|P-value:8.89E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:4.14|P-value:9.95E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.19|P-value:7.95E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.18|P-value:4.52E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.08|P-value:6.45E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.12|P-value:5.70E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.26|P-value:5.94E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.71|P-value:6.11E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.94|P-value:2.33E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.78|P-value:4.57E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.32|P-value:4.49E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.99|P-value:1.03E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.47|P-value:5.79E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.62|P-value:1.07E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.48|P-value:1.52E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.63|P-value:8.53E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-3.48|P-value:5.59E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.10|P-value:1.18E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-5.18|P-value:4.05E-7 ID:SGTC_1827|Compound:berberine|FD-Score:3.32|P-value:2.72E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.17|P-value:4.77E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.53|P-value:4.77E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.48|P-value:2.07E-6 ID:SGTC_2006|Compound:4011487|FD-Score:4.15|P-value:9.56E-6 ID:SGTC_2055|Compound:5235184|FD-Score:5.74|P-value:2.50E-9 ID:SGTC_2094|Compound:5332512|FD-Score:4.36|P-value:3.63E-6 ID:SGTC_2279|Compound:7948423|FD-Score:-3.48|P-value:5.64E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.40|P-value:2.07E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.49|P-value:1.46E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.03|P-value:7.28E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.97|P-value:9.31E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.87|P-value:3.25E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.71|P-value:2.44E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.25|P-value:3.58E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.47|P-value:5.89E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.77|P-value:2.11E-9 ID:SGTC_2517|Compound:totarol|FD-Score:-4.05|P-value:6.67E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.44|P-value:1.78E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.54|P-value:1.19E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.09|P-value:1.25E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.25|P-value:3.58E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.32|P-value:2.79E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.61|P-value:3.52E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.70|P-value:6.47E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.50|P-value:5.36E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.12|P-value:5.56E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.03|P-value:7.59E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.38|P-value:7.84E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.96|P-value:2.14E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.96|P-value:1.96E-7 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.61|P-value:9.16E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.88|P-value:2.95E-7 ID:SGTC_572|Compound:0960-0087|FD-Score:3.10|P-value:5.96E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:5.83|P-value:1.48E-9 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.55|P-value:4.49E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.70|P-value:6.41E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.59|P-value:9.79E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.69|P-value:6.77E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.70|P-value:2.57E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.89|P-value:2.94E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:5.43|P-value:1.55E-8 ID:SGTC_882|Compound:0843-0131|FD-Score:4.97|P-value:1.83E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.50|P-value:1.39E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.10|P-value:6.06E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.62|P-value:8.89E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:4.14|P-value:9.95E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.19|P-value:7.95E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.18|P-value:4.52E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.08|P-value:6.45E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.12|P-value:5.70E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.26|P-value:5.94E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.71|P-value:6.11E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.94|P-value:2.33E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.78|P-value:4.57E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.32|P-value:4.49E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.99|P-value:1.03E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.47|P-value:5.79E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.62|P-value:1.07E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.48|P-value:1.52E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.63|P-value:8.53E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-3.48|P-value:5.59E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.10|P-value:1.18E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-5.18|P-value:4.05E-7 ID:SGTC_1827|Compound:berberine|FD-Score:3.32|P-value:2.72E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.17|P-value:4.77E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.53|P-value:4.77E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.48|P-value:2.07E-6 ID:SGTC_2006|Compound:4011487|FD-Score:4.15|P-value:9.56E-6 ID:SGTC_2055|Compound:5235184|FD-Score:5.74|P-value:2.50E-9 ID:SGTC_2094|Compound:5332512|FD-Score:4.36|P-value:3.63E-6 ID:SGTC_2279|Compound:7948423|FD-Score:-3.48|P-value:5.64E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.40|P-value:2.07E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.49|P-value:1.46E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.03|P-value:7.28E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.97|P-value:9.31E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.87|P-value:3.25E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.71|P-value:2.44E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.25|P-value:3.58E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.47|P-value:5.89E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.77|P-value:2.11E-9 ID:SGTC_2517|Compound:totarol|FD-Score:-4.05|P-value:6.67E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.44|P-value:1.78E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.54|P-value:1.19E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.09|P-value:1.25E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.25|P-value:3.58E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.32|P-value:2.79E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.61|P-value:3.52E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.70|P-value:6.47E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.50|P-value:5.36E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.12|P-value:5.56E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.03|P-value:7.59E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.38|P-value:7.84E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.96|P-value:2.14E-5

Top fitness defect scores for YNL054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_615 k087-0205 5.83 167.0 µM 1.48E-9 4 2.75E-9
2 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 5.77 54.6 µM 2.11E-9 RPP1 & pyrimidine depletion 9 3.93E-9
3 SGTC_2055 5235184 5.74 200.0 µM 2.50E-9 ERG2 9 4.64E-9
4 SGTC_868 0527-0199 5.43 213.0 µM 1.55E-8 fatty acid desaturase (OLE1) 9 2.86E-8
5 SGTC_882 0843-0131 4.97 351.0 µM 1.83E-7 5 3.32E-7
6 SGTC_264 promethazine 4.96 12.5 mM 1.96E-7 DNA intercalators 32 3.56E-7
7 SGTC_392 N-ethylmaleimide 4.88 8.3 µM 2.95E-7 RNA pol III & RNase P/MRP 5 5.34E-7
8 SGTC_1619 st003326 4.62 88.7 µM 1.07E-6 60S ribosome export 8 1.92E-6
9 SGTC_1919 st067113 4.48 52.3 µM 2.07E-6 TSC3-RPN4 20 3.67E-6
10 SGTC_2094 5332512 4.36 191.7 µM 3.63E-6 16 6.39E-6
11 SGTC_1511 0906-3109 4.32 28.5 µM 4.49E-6 excess fatty acid 34 7.89E-6
12 SGTC_1416 3966-0321 4.26 25.3 µM 5.94E-6 6 1.04E-5
13 SGTC_1082 camptothecin 4.19 424.9 nM 7.95E-6 DNA damage response 41 1.39E-5
14 SGTC_2006 4011487 4.15 200.0 µM 9.56E-6 endomembrane recycling 75 1.66E-5
15 SGTC_1081 sertraline 4.14 6.0 µM 9.95E-6 60S ribosome export 30 1.73E-5
16 SGTC_1744 st037937 4.10 38.9 µM 1.18E-5 26 2.05E-5
17 SGTC_2691 st077356 4.09 60.2 µM 1.25E-5 24 2.16E-5
18 SGTC_3208 9114115 3.96 49.5 µM 2.14E-5 34 3.68E-5
19 SGTC_1452 4194-0072 3.94 190.0 µM 2.33E-5 14 4.01E-5
20 SGTC_831 k061-1017 3.89 217.0 µM 2.94E-5 translation 67 5.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.59E-12 YBR072W HSP26 hom Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity
0.107 5.91E-10 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.093 7.70E-8 YBR152W SPP381 het mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
0.083 1.35E-6 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.079 4.49E-6 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.079 4.60E-6 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.078 6.33E-6 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.076 9.91E-6 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.076 1.02E-5 YOR064C YNG1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
0.071 3.83E-5 YER047C SAP1 hom Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
0.070 5.51E-5 YMR313C TGL3 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation
0.069 7.14E-5 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
0.067 9.73E-5 YOL064C MET22 hom Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
0.067 1.01E-4 YNL170W_d YNL170W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.066 1.29E-4 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression