YNL055C / POR1

Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL055C / POR1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:4.70|P-value:2.14E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.46|P-value:5.18E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.27|P-value:2.29E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:4.00|P-value:2.55E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.16|P-value:1.49E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.23|P-value:1.18E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.43|P-value:5.72E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.46|P-value:5.22E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.31|P-value:8.86E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.48|P-value:9.31E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:-4.16|P-value:1.39E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:6.46|P-value:9.32E-9 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.39|P-value:6.61E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.76|P-value:5.05E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.66|P-value:7.33E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.08|P-value:1.93E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.05|P-value:4.09E-10 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.63|P-value:7.39E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.66|P-value:2.56E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.03|P-value:2.32E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:7.05|P-value:4.16E-10 ID:SGTC_1735|Compound:st034310|FD-Score:4.30|P-value:9.11E-5 ID:SGTC_1778|Compound:st046819|FD-Score:4.47|P-value:4.99E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.08|P-value:1.93E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.64|P-value:7.76E-4 ID:SGTC_2176|Compound:5809774|FD-Score:6.41|P-value:1.22E-8 ID:SGTC_2183|Compound:6420625|FD-Score:6.10|P-value:5.49E-8 ID:SGTC_2207|Compound:7258803|FD-Score:4.63|P-value:2.77E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-4.36|P-value:6.77E-5 ID:SGTC_2349|Compound:9023730|FD-Score:4.22|P-value:1.19E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.59|P-value:8.39E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.88|P-value:3.73E-4 ID:SGTC_2414|Compound:st077232|FD-Score:6.28|P-value:2.30E-8 ID:SGTC_2415|Compound:st077333|FD-Score:3.97|P-value:2.77E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.65|P-value:6.98E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.69|P-value:6.67E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.45|P-value:1.07E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.37|P-value:7.09E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.59|P-value:8.94E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-4.28|P-value:9.11E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.40|P-value:1.31E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-3.96|P-value:2.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.27|P-value:9.49E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.81|P-value:1.44E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.41|P-value:6.31E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.54|P-value:9.83E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.49|P-value:4.24E-5 ID:SGTC_3309|Compound:9129340|FD-Score:4.73|P-value:1.92E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-3.82|P-value:4.12E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.70|P-value:2.14E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.46|P-value:5.18E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.27|P-value:2.29E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:4.00|P-value:2.55E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.16|P-value:1.49E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.23|P-value:1.18E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.43|P-value:5.72E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.46|P-value:5.22E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.31|P-value:8.86E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.48|P-value:9.31E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:-4.16|P-value:1.39E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:6.46|P-value:9.32E-9 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.39|P-value:6.61E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.76|P-value:5.05E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.66|P-value:7.33E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.08|P-value:1.93E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.05|P-value:4.09E-10 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.63|P-value:7.39E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.66|P-value:2.56E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.03|P-value:2.32E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:7.05|P-value:4.16E-10 ID:SGTC_1735|Compound:st034310|FD-Score:4.30|P-value:9.11E-5 ID:SGTC_1778|Compound:st046819|FD-Score:4.47|P-value:4.99E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.08|P-value:1.93E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.64|P-value:7.76E-4 ID:SGTC_2176|Compound:5809774|FD-Score:6.41|P-value:1.22E-8 ID:SGTC_2183|Compound:6420625|FD-Score:6.10|P-value:5.49E-8 ID:SGTC_2207|Compound:7258803|FD-Score:4.63|P-value:2.77E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-4.36|P-value:6.77E-5 ID:SGTC_2349|Compound:9023730|FD-Score:4.22|P-value:1.19E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.59|P-value:8.39E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.88|P-value:3.73E-4 ID:SGTC_2414|Compound:st077232|FD-Score:6.28|P-value:2.30E-8 ID:SGTC_2415|Compound:st077333|FD-Score:3.97|P-value:2.77E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.65|P-value:6.98E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.69|P-value:6.67E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.45|P-value:1.07E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.37|P-value:7.09E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.59|P-value:8.94E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-4.28|P-value:9.11E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.40|P-value:1.31E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-3.96|P-value:2.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.27|P-value:9.49E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.81|P-value:1.44E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.41|P-value:6.31E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.54|P-value:9.83E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.49|P-value:4.24E-5 ID:SGTC_3309|Compound:9129340|FD-Score:4.73|P-value:1.92E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-3.82|P-value:4.12E-4

Top fitness defect scores for YNL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1371 2421-0008 7.05 32.7 µM 4.09E-10 mitochondrial processes 3 8.80E-13
2 SGTC_1510 1123-0200 7.05 71.5 µM 4.16E-10 11 9.00E-13
3 SGTC_1100 amiodarone 6.46 5.1 µM 9.32E-9 1 5.26E-11
4 SGTC_2176 5809774 6.41 34.0 µM 1.22E-8 mitochondrial processes 2 7.46E-11
5 SGTC_2414 st077232 6.28 92.9 µM 2.30E-8 3 1.71E-10
6 SGTC_2183 6420625 6.10 130.5 µM 5.49E-8 mitochondrial processes 11 5.35E-10
7 SGTC_1072 oxiconazole 5.48 14.9 nM 9.31E-7 ergosterol depletion effects on membrane 26 2.15E-8
8 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 5.45 13.2 µM 1.07E-6 4 2.57E-8
9 SGTC_2756 carbadox 5.40 75.1 µM 1.31E-6 25 3.37E-8
10 SGTC_354 2783-3500 5.27 4.9 µM 2.29E-6 cell wall 26 6.97E-8
11 SGTC_2920 7982904 4.81 15.8 µM 1.44E-5 6 7.67E-7
12 SGTC_3309 9129340 4.73 25.8 µM 1.92E-5 6 1.12E-6
13 SGTC_86 0417-1630 4.70 471.9 µM 2.14E-5 ubiquinone biosynthesis & proteasome 120 1.28E-6
14 SGTC_1380 2291-0730 4.66 164.0 µM 2.56E-5 11 1.62E-6
15 SGTC_2207 7258803 4.63 200.0 µM 2.77E-5 3 1.79E-6
16 SGTC_1778 st046819 4.47 58.9 µM 4.99E-5 15 3.86E-6
17 SGTC_351 caspofungin 4.46 25.0 nM 5.18E-5 cell wall 75 4.06E-6
18 SGTC_874 0599-0792 4.46 117.0 µM 5.22E-5 16 4.10E-6
19 SGTC_865 0488-0499 4.43 301.0 µM 5.72E-5 10 4.62E-6
20 SGTC_2954 9074818 4.41 52.7 µM 6.31E-5 27 5.24E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.86E-10 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.102 3.11E-9 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.099 8.36E-9 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.095 3.53E-8 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.092 9.00E-8 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.091 1.12E-7 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.089 2.07E-7 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.089 2.86E-7 YPL271W ATP15 hom Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.088 3.62E-7 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.085 7.36E-7 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.085 7.80E-7 YLR207W HRD3 hom Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
0.081 2.40E-6 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.080 3.65E-6 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.078 5.89E-6 YGL244W RTF1 hom Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.078 6.51E-6 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit