YNL056W / OCA2

Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL056W / OCA2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.87|P-value:3.76E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:7.39|P-value:3.05E-14 ID:SGTC_14|Compound:0354-0009|FD-Score:3.36|P-value:3.20E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:8.60|P-value:1.19E-18 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.07|P-value:1.32E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.27|P-value:6.67E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:8.36|P-value:1.01E-17 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.89|P-value:3.70E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:9.41|P-value:5.63E-22 ID:SGTC_84|Compound:0443-0269|FD-Score:5.43|P-value:1.78E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:10.40|P-value:1.78E-26 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.41|P-value:3.46E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.46|P-value:1.42E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:3.82|P-value:5.28E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.92|P-value:3.47E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.11|P-value:8.00E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.15|P-value:2.06E-10 ID:SGTC_448|Compound:monastrol|FD-Score:-3.30|P-value:3.82E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.72|P-value:7.37E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.69|P-value:8.89E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:5.44|P-value:1.65E-8 ID:SGTC_658|Compound:3253-0951|FD-Score:4.03|P-value:2.12E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.47|P-value:2.12E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.82|P-value:5.19E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.19|P-value:6.13E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.22|P-value:8.38E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:5.28|P-value:4.17E-8 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.23|P-value:4.94E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.69|P-value:8.49E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.29|P-value:4.21E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.08|P-value:3.34E-10 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.93|P-value:3.30E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.23|P-value:5.25E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.41|P-value:3.78E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.95|P-value:3.04E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.94|P-value:3.14E-5 ID:SGTC_1516|Compound:st013856|FD-Score:-3.88|P-value:3.86E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.22|P-value:5.06E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.06|P-value:1.91E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.97|P-value:2.55E-5 ID:SGTC_1754|Compound:st042065|FD-Score:7.23|P-value:1.04E-13 ID:SGTC_1760|Compound:st045453|FD-Score:5.64|P-value:5.07E-9 ID:SGTC_1761|Compound:st044296|FD-Score:-4.61|P-value:1.31E-6 ID:SGTC_1763|Compound:st044482|FD-Score:-6.19|P-value:1.45E-10 ID:SGTC_1766|Compound:st045414|FD-Score:-6.98|P-value:5.54E-13 ID:SGTC_1800|Compound:st050079|FD-Score:3.28|P-value:4.38E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.05|P-value:1.97E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.54|P-value:1.49E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.29|P-value:6.70E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.48|P-value:2.72E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.33|P-value:3.63E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.86|P-value:4.43E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.97|P-value:2.77E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.01|P-value:1.82E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.93|P-value:3.29E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.25|P-value:4.94E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-4.02|P-value:2.10E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.36|P-value:3.25E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.10|P-value:1.42E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.03|P-value:2.01E-5 ID:SGTC_3212|Compound:9128307|FD-Score:6.64|P-value:7.37E-12 ID:SGTC_7|Compound:0192-1582|FD-Score:4.87|P-value:3.76E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:7.39|P-value:3.05E-14 ID:SGTC_14|Compound:0354-0009|FD-Score:3.36|P-value:3.20E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:8.60|P-value:1.19E-18 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.07|P-value:1.32E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.27|P-value:6.67E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:8.36|P-value:1.01E-17 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.89|P-value:3.70E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:9.41|P-value:5.63E-22 ID:SGTC_84|Compound:0443-0269|FD-Score:5.43|P-value:1.78E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:10.40|P-value:1.78E-26 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.41|P-value:3.46E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.46|P-value:1.42E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:3.82|P-value:5.28E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.92|P-value:3.47E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.11|P-value:8.00E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.15|P-value:2.06E-10 ID:SGTC_448|Compound:monastrol|FD-Score:-3.30|P-value:3.82E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.72|P-value:7.37E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.69|P-value:8.89E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:5.44|P-value:1.65E-8 ID:SGTC_658|Compound:3253-0951|FD-Score:4.03|P-value:2.12E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.47|P-value:2.12E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.82|P-value:5.19E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.19|P-value:6.13E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.22|P-value:8.38E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:5.28|P-value:4.17E-8 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.23|P-value:4.94E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.69|P-value:8.49E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.29|P-value:4.21E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.08|P-value:3.34E-10 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.93|P-value:3.30E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.23|P-value:5.25E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.41|P-value:3.78E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.95|P-value:3.04E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.94|P-value:3.14E-5 ID:SGTC_1516|Compound:st013856|FD-Score:-3.88|P-value:3.86E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.22|P-value:5.06E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.06|P-value:1.91E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.97|P-value:2.55E-5 ID:SGTC_1754|Compound:st042065|FD-Score:7.23|P-value:1.04E-13 ID:SGTC_1760|Compound:st045453|FD-Score:5.64|P-value:5.07E-9 ID:SGTC_1761|Compound:st044296|FD-Score:-4.61|P-value:1.31E-6 ID:SGTC_1763|Compound:st044482|FD-Score:-6.19|P-value:1.45E-10 ID:SGTC_1766|Compound:st045414|FD-Score:-6.98|P-value:5.54E-13 ID:SGTC_1800|Compound:st050079|FD-Score:3.28|P-value:4.38E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.05|P-value:1.97E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.54|P-value:1.49E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.29|P-value:6.70E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.48|P-value:2.72E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.33|P-value:3.63E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.86|P-value:4.43E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.97|P-value:2.77E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.01|P-value:1.82E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.93|P-value:3.29E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.25|P-value:4.94E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-4.02|P-value:2.10E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.36|P-value:3.25E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.10|P-value:1.42E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.03|P-value:2.01E-5 ID:SGTC_3212|Compound:9128307|FD-Score:6.64|P-value:7.37E-12

Top fitness defect scores for YNL056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_87 0100-0052 10.40 35.5 µM 1.78E-26 4 1.11E-25
2 SGTC_64 000l-0018 9.41 272.1 µM 5.63E-22 ubiquinone biosynthesis & proteasome 41 2.50E-21
3 SGTC_18 0111-0177 8.60 500.0 nM 1.19E-18 7 4.10E-18
4 SGTC_59 0330-0160 8.36 1.3 µM 1.01E-17 15 3.26E-17
5 SGTC_8 0354-0001 7.39 70.0 µM 3.05E-14 14 7.58E-14
6 SGTC_1754 st042065 7.23 16.1 µM 1.04E-13 NEO1-PIK1 68 2.48E-13
7 SGTC_3212 9128307 6.64 49.5 µM 7.37E-12 11 1.53E-11
8 SGTC_445 e6 berbamine 6.15 66.0 µM 2.06E-10 NEO1-PIK1 26 3.85E-10
9 SGTC_1226 3909-7979 6.08 35.4 µM 3.34E-10 14 6.15E-10
10 SGTC_1760 st045453 5.64 10.4 µM 5.07E-9 NEO1-PIK1 90 8.55E-9
11 SGTC_146 3448-8650 5.46 53.1 µM 1.42E-8 NEO1-PIK1 62 2.32E-8
12 SGTC_632 0781-2353 5.44 4.7 µM 1.65E-8 Golgi 13 2.68E-8
13 SGTC_84 0443-0269 5.43 128.8 µM 1.78E-8 6 2.89E-8
14 SGTC_937 3122-0005 5.28 46.7 µM 4.17E-8 11 6.58E-8
15 SGTC_46 0329-0187a 5.07 2.2 µM 1.32E-7 37 2.01E-7
16 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.01 100.0 µM 1.82E-7 19 2.74E-7
17 SGTC_7 0192-1582 4.87 4.2 µM 3.76E-7 39 5.53E-7
18 SGTC_1877 wortmannin 4.48 25.0 µM 2.72E-6 81 3.77E-6
19 SGTC_1483 3453-0561 4.41 55.9 µM 3.78E-6 15 5.18E-6
20 SGTC_1861 st057647 4.29 17.4 µM 6.70E-6 13 9.02E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.379 4.81E-115 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.299 3.88E-70 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.278 1.84E-60 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.266 2.38E-55 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.250 6.30E-49 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.233 1.69E-42 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.227 1.36E-40 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.218 1.73E-37 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.214 3.33E-36 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.211 3.68E-35 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.204 7.40E-33 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.194 6.47E-30 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.194 1.16E-29 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.193 1.42E-29 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.189 3.53E-28 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies