YNL057W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL057W / YNL057W

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-3.30|P-value:2.87E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.03|P-value:7.98E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.58|P-value:9.46E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:2.97|P-value:9.71E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.26|P-value:3.41E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.10|P-value:6.15E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-5.31|P-value:1.49E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:4.03|P-value:1.31E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.02|P-value:8.23E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:2.98|P-value:9.34E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.16|P-value:4.83E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.04|P-value:7.47E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.62|P-value:7.91E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.26|P-value:4.36E-6 ID:SGTC_1738|Compound:st035555|FD-Score:4.88|P-value:1.80E-7 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.10|P-value:6.22E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.60|P-value:8.75E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.05|P-value:1.22E-5 ID:SGTC_2050|Compound:5263056|FD-Score:4.22|P-value:5.36E-6 ID:SGTC_2060|Compound:5238662|FD-Score:3.40|P-value:1.95E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-2.98|P-value:9.33E-4 ID:SGTC_2166|Compound:5933061|FD-Score:7.08|P-value:7.85E-14 ID:SGTC_2179|Compound:6298986|FD-Score:3.69|P-value:5.93E-5 ID:SGTC_2185|Compound:6113692|FD-Score:-3.41|P-value:1.84E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.16|P-value:4.83E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.39|P-value:2.07E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.28|P-value:3.95E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-4.61|P-value:7.68E-7 ID:SGTC_2356|Compound:9061756|FD-Score:-2.98|P-value:9.51E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.65|P-value:5.99E-7 ID:SGTC_2384|Compound:9036245|FD-Score:4.35|P-value:2.90E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.16|P-value:4.98E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.97|P-value:9.86E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:3.88E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.23|P-value:3.81E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:2.97|P-value:9.67E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.12|P-value:5.66E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.22|P-value:3.97E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.81|P-value:2.66E-7 ID:SGTC_3215|Compound:9129942|FD-Score:3.50|P-value:1.32E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.56|P-value:9.70E-7 ID:SGTC_3289|Compound:9119912|FD-Score:3.03|P-value:7.91E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-2.98|P-value:9.40E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.30|P-value:2.87E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.03|P-value:7.98E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.58|P-value:9.46E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:2.97|P-value:9.71E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.26|P-value:3.41E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.10|P-value:6.15E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-5.31|P-value:1.49E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:4.03|P-value:1.31E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.02|P-value:8.23E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:2.98|P-value:9.34E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.16|P-value:4.83E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.04|P-value:7.47E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.62|P-value:7.91E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.26|P-value:4.36E-6 ID:SGTC_1738|Compound:st035555|FD-Score:4.88|P-value:1.80E-7 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.10|P-value:6.22E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.60|P-value:8.75E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.05|P-value:1.22E-5 ID:SGTC_2050|Compound:5263056|FD-Score:4.22|P-value:5.36E-6 ID:SGTC_2060|Compound:5238662|FD-Score:3.40|P-value:1.95E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-2.98|P-value:9.33E-4 ID:SGTC_2166|Compound:5933061|FD-Score:7.08|P-value:7.85E-14 ID:SGTC_2179|Compound:6298986|FD-Score:3.69|P-value:5.93E-5 ID:SGTC_2185|Compound:6113692|FD-Score:-3.41|P-value:1.84E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.16|P-value:4.83E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.39|P-value:2.07E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.28|P-value:3.95E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-4.61|P-value:7.68E-7 ID:SGTC_2356|Compound:9061756|FD-Score:-2.98|P-value:9.51E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.65|P-value:5.99E-7 ID:SGTC_2384|Compound:9036245|FD-Score:4.35|P-value:2.90E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.16|P-value:4.98E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.97|P-value:9.86E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:3.88E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.23|P-value:3.81E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:2.97|P-value:9.67E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.12|P-value:5.66E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.22|P-value:3.97E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.81|P-value:2.66E-7 ID:SGTC_3215|Compound:9129942|FD-Score:3.50|P-value:1.32E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.56|P-value:9.70E-7 ID:SGTC_3289|Compound:9119912|FD-Score:3.03|P-value:7.91E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-2.98|P-value:9.40E-4

Top fitness defect scores for YNL057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2166 5933061 7.08 31.5 µM 7.85E-14 tubulin folding & SWR complex 8 7.44E-13
2 SGTC_1738 st035555 4.88 74.0 µM 1.80E-7 TSC3-RPN4 16 5.35E-7
3 SGTC_2752 diclazuril 4.81 33.1 µM 2.66E-7 81 7.67E-7
4 SGTC_3218 9131285 4.56 49.5 µM 9.70E-7 endomembrane recycling 26 2.53E-6
5 SGTC_2384 9036245 4.35 200.0 µM 2.90E-6 26 6.94E-6
6 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 4.26 61.8 µM 4.36E-6 ergosterol biosynthesis 4 1.01E-5
7 SGTC_2050 5263056 4.22 171.0 µM 5.36E-6 fatty acid desaturase (OLE1) 36 1.22E-5
8 SGTC_2049 5262831 4.05 67.2 µM 1.22E-5 24 2.60E-5
9 SGTC_372 0155-0182 4.03 15.9 µM 1.31E-5 mitochondrial response to ROS 28 2.78E-5
10 SGTC_2179 6298986 3.69 200.0 µM 5.93E-5 heme requiring 23 1.12E-4
11 SGTC_1517 deoxycholic acid methyl ester 3.62 49.2 µM 7.91E-5 15 1.46E-4
12 SGTC_1969 st069479 3.60 40.1 µM 8.75E-5 19 1.61E-4
13 SGTC_178 4092-0806 3.58 87.5 µM 9.46E-5 ergosterol depletion effects on membrane 115 1.73E-4
14 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 3.51 54.6 µM 1.26E-4 RPP1 & pyrimidine depletion 40 2.26E-4
15 SGTC_3215 9129942 3.50 49.5 µM 1.32E-4 22 2.35E-4
16 SGTC_2060 5238662 3.40 140.0 µM 1.95E-4 44 3.38E-4
17 SGTC_243 5hr heat shock (37°C) + splitomicin 3.38 1.0 µM 2.15E-4 heat shock/prefoldin 77 3.68E-4
18 SGTC_2574 2',4'-dihydroxychalcone 3.22 14.6 µM 3.88E-4 43 6.37E-4
19 SGTC_2749 bexarotene 3.22 57.4 µM 3.97E-4 53 6.50E-4
20 SGTC_2237 6667747 3.16 47.2 µM 4.83E-4 34 7.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 9.70E-12 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.111 1.11E-10 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.109 2.52E-10 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.108 3.33E-10 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.105 1.11E-9 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.100 5.93E-9 YER096W SHC1 hom Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication
0.100 7.66E-9 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.099 8.75E-9 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.092 9.98E-8 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.091 1.22E-7 YML032C RAD52 hom Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
0.090 1.53E-7 YPR154W PIN3 hom Protein that induces appearance of [PIN+] prion when overproduced
0.090 1.82E-7 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.089 2.65E-7 YIL034C CAP2 hom Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.083 1.42E-6 YDL051W LHP1 hom RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
0.083 1.45E-6 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication