YNL058C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL058C / YNL058C

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:3.13|P-value:5.28E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.18|P-value:3.31E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:4.20|P-value:5.79E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.25|P-value:4.63E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.07|P-value:8.67E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.81|P-value:4.89E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.95|P-value:1.81E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:2.99|P-value:8.64E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.10|P-value:5.88E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.97|P-value:1.70E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:4.11|P-value:8.88E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.36|P-value:3.05E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.23|P-value:3.56E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.14|P-value:5.04E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.12|P-value:5.49E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.51|P-value:1.23E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.81|P-value:2.71E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:3.96|P-value:1.73E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.57|P-value:9.50E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.67|P-value:6.12E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.35|P-value:2.30E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.59|P-value:8.33E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.01|P-value:8.05E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.89|P-value:3.50E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.84|P-value:4.29E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.96|P-value:1.73E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.10|P-value:7.80E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.92|P-value:2.13E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.33|P-value:3.41E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.91|P-value:2.23E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.57|P-value:9.36E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.07|P-value:6.42E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:2.99|P-value:8.63E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.30|P-value:2.75E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.58|P-value:1.29E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.38|P-value:2.38E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-3.56|P-value:1.37E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2073|Compound:5212005|FD-Score:4.34|P-value:2.98E-6 ID:SGTC_2190|Compound:6049624|FD-Score:-3.43|P-value:2.27E-4 ID:SGTC_2194|Compound:5927483|FD-Score:-3.46|P-value:2.05E-4 ID:SGTC_2223|Compound:6903751|FD-Score:5.87|P-value:4.98E-10 ID:SGTC_2226|Compound:7298446|FD-Score:4.00|P-value:1.45E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-4.94|P-value:2.02E-7 ID:SGTC_2276|Compound:7947513|FD-Score:4.97|P-value:1.09E-7 ID:SGTC_2277|Compound:7947813|FD-Score:4.20|P-value:5.68E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.38|P-value:2.02E-4 ID:SGTC_2424|Compound:5537928|FD-Score:2.97|P-value:9.25E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.00|P-value:8.38E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.21|P-value:3.90E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.95|P-value:9.99E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.66|P-value:9.10E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.36|P-value:2.20E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.30|P-value:2.77E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.00|P-value:8.29E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.19|P-value:5.72E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.77|P-value:5.75E-5 ID:SGTC_3277|Compound:9138724|FD-Score:3.27|P-value:3.14E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.22|P-value:3.71E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.13|P-value:5.28E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.18|P-value:3.31E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:4.20|P-value:5.79E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.25|P-value:4.63E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.07|P-value:8.67E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.81|P-value:4.89E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.95|P-value:1.81E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:2.99|P-value:8.64E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.10|P-value:5.88E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.97|P-value:1.70E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:4.11|P-value:8.88E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.36|P-value:3.05E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.23|P-value:3.56E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.14|P-value:5.04E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.12|P-value:5.49E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.51|P-value:1.23E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.81|P-value:2.71E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:3.96|P-value:1.73E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.57|P-value:9.50E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.67|P-value:6.12E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.35|P-value:2.30E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.59|P-value:8.33E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.01|P-value:8.05E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.89|P-value:3.50E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.84|P-value:4.29E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.96|P-value:1.73E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.10|P-value:7.80E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.92|P-value:2.13E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.33|P-value:3.41E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.91|P-value:2.23E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.57|P-value:9.36E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.07|P-value:6.42E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:2.99|P-value:8.63E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.30|P-value:2.75E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.58|P-value:1.29E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.38|P-value:2.38E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-3.56|P-value:1.37E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2073|Compound:5212005|FD-Score:4.34|P-value:2.98E-6 ID:SGTC_2190|Compound:6049624|FD-Score:-3.43|P-value:2.27E-4 ID:SGTC_2194|Compound:5927483|FD-Score:-3.46|P-value:2.05E-4 ID:SGTC_2223|Compound:6903751|FD-Score:5.87|P-value:4.98E-10 ID:SGTC_2226|Compound:7298446|FD-Score:4.00|P-value:1.45E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-4.94|P-value:2.02E-7 ID:SGTC_2276|Compound:7947513|FD-Score:4.97|P-value:1.09E-7 ID:SGTC_2277|Compound:7947813|FD-Score:4.20|P-value:5.68E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.38|P-value:2.02E-4 ID:SGTC_2424|Compound:5537928|FD-Score:2.97|P-value:9.25E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.00|P-value:8.38E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.21|P-value:3.90E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.95|P-value:9.99E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.66|P-value:9.10E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.36|P-value:2.20E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.30|P-value:2.77E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.00|P-value:8.29E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.19|P-value:5.72E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.77|P-value:5.75E-5 ID:SGTC_3277|Compound:9138724|FD-Score:3.27|P-value:3.14E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.22|P-value:3.71E-4

Top fitness defect scores for YNL058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2223 6903751 5.87 107.6 µM 4.98E-10 superoxide 4 2.19E-9
2 SGTC_150 3970-0969 5.18 77.2 µM 3.31E-8 34 1.09E-7
3 SGTC_2276 7947513 4.97 42.1 µM 1.09E-7 11 3.29E-7
4 SGTC_896 0964-0007 4.81 44.5 µM 2.71E-7 8 7.72E-7
5 SGTC_1216 1165-0504 4.59 9.7 µM 8.33E-7 7 2.19E-6
6 SGTC_2050 5263056 4.38 171.0 µM 2.38E-6 fatty acid desaturase (OLE1) 33 5.83E-6
7 SGTC_2073 5212005 4.34 126.0 µM 2.98E-6 6 7.17E-6
8 SGTC_2277 7947813 4.20 106.9 µM 5.68E-6 RSC complex & mRNA processing 21 1.31E-5
9 SGTC_168 3970-0862 4.20 530.5 µM 5.79E-6 106 1.33E-5
10 SGTC_718 1130-0073 4.11 349.0 µM 8.88E-6 17 1.98E-5
11 SGTC_2226 7298446 4.00 200.0 µM 1.45E-5 4 3.14E-5
12 SGTC_717 1532-0246 3.97 73.2 µM 1.70E-5 Golgi 35 3.63E-5
13 SGTC_1485 3909-9022 3.96 254.0 µM 1.73E-5 RPP1 & pyrimidine depletion 7 3.68E-5
14 SGTC_914 3820-6779 3.96 408.0 µM 1.73E-5 23 3.69E-5
15 SGTC_569 4130-2812 3.95 160.0 µM 1.81E-5 amide catabolism 6 3.84E-5
16 SGTC_1584 6-fluoro-dl-tryptophan 3.92 90.0 µM 2.13E-5 mitochondrial processes 11 4.47E-5
17 SGTC_1586 deoxycorticosterone acetate 3.91 53.7 µM 2.23E-5 10 4.66E-5
18 SGTC_948 3448-0295 3.67 75.3 µM 6.12E-5 35 1.19E-4
19 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.57 67.5 µM 9.36E-5 62 1.77E-4
20 SGTC_944 3370-0224 3.57 231.0 µM 9.50E-5 34 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.35E-14 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.114 3.41E-11 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.097 1.72E-8 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.093 7.34E-8 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.089 2.10E-7 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.089 2.30E-7 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.080 3.20E-6 YLR347C KAP95 het Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
0.077 7.30E-6 YLR182W SWI6 hom Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
0.077 8.57E-6 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.077 9.16E-6 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.075 1.50E-5 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.073 2.33E-5 YMR189W GCV2 hom P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
0.072 2.83E-5 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.071 4.15E-5 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.069 6.28E-5 YGR218W CRM1 het Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin