YNL059C / ARP5

Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL059C / ARP5

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.64|P-value:1.22E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:7.84|P-value:4.07E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.69|P-value:1.41E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.08|P-value:9.31E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-5.72|P-value:4.82E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.46|P-value:3.71E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.09|P-value:8.42E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:3.74|P-value:1.16E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.87|P-value:7.04E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.46|P-value:5.43E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.97|P-value:1.85E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.17|P-value:1.66E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:5.44|P-value:3.93E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:3.17|P-value:9.37E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.55|P-value:2.41E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.20|P-value:8.45E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:7.58|P-value:3.16E-14 ID:SGTC_625|Compound:k213-0058|FD-Score:3.39|P-value:4.37E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.77|P-value:1.28E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:3.52|P-value:2.68E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:8.15|P-value:3.55E-16 ID:SGTC_955|Compound:1216-0110|FD-Score:3.34|P-value:5.13E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.49|P-value:2.96E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.03|P-value:3.44E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.00|P-value:2.82E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.67|P-value:1.52E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.05|P-value:3.30E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:9.24|P-value:2.69E-20 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.24|P-value:7.36E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.63|P-value:2.50E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.49|P-value:2.97E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.42|P-value:3.82E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.46|P-value:2.48E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.76|P-value:1.08E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.58|P-value:1.57E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.13|P-value:2.37E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.52|P-value:2.43E-8 ID:SGTC_1781|Compound:st038725|FD-Score:3.86|P-value:7.10E-5 ID:SGTC_2053|Compound:5265679|FD-Score:5.20|P-value:1.40E-7 ID:SGTC_2054|Compound:5233173|FD-Score:4.24|P-value:1.49E-5 ID:SGTC_2060|Compound:5238662|FD-Score:5.83|P-value:4.13E-9 ID:SGTC_2185|Compound:6113692|FD-Score:5.09|P-value:2.53E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.50|P-value:2.86E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.68|P-value:1.47E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.30|P-value:5.88E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_2474|Compound:5321570|FD-Score:4.73|P-value:1.53E-6 ID:SGTC_2478|Compound:5763493|FD-Score:3.57|P-value:2.25E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.60|P-value:1.45E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.33|P-value:6.69E-6 ID:SGTC_2521|Compound:angolensin|FD-Score:3.95|P-value:4.93E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.72|P-value:1.26E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.65|P-value:1.63E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.04|P-value:3.40E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.21|P-value:8.18E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.37|P-value:4.62E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.52|P-value:2.69E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.98|P-value:4.41E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.59|P-value:1.63E-8 ID:SGTC_3025|Compound:9087895|FD-Score:3.23|P-value:7.43E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.58|P-value:2.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.92|P-value:5.67E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.64|P-value:1.72E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.67|P-value:2.02E-11 ID:SGTC_3331|Compound:9141060|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.64|P-value:1.22E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:7.84|P-value:4.07E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.69|P-value:1.41E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.08|P-value:9.31E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-5.72|P-value:4.82E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.46|P-value:3.71E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.09|P-value:8.42E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:3.74|P-value:1.16E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.87|P-value:7.04E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.46|P-value:5.43E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.97|P-value:1.85E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.17|P-value:1.66E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:5.44|P-value:3.93E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:3.17|P-value:9.37E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.55|P-value:2.41E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.20|P-value:8.45E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:7.58|P-value:3.16E-14 ID:SGTC_625|Compound:k213-0058|FD-Score:3.39|P-value:4.37E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.77|P-value:1.28E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:3.52|P-value:2.68E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:8.15|P-value:3.55E-16 ID:SGTC_955|Compound:1216-0110|FD-Score:3.34|P-value:5.13E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.49|P-value:2.96E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.03|P-value:3.44E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.00|P-value:2.82E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.67|P-value:1.52E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.05|P-value:3.30E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:9.24|P-value:2.69E-20 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.24|P-value:7.36E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.63|P-value:2.50E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.49|P-value:2.97E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.42|P-value:3.82E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.46|P-value:2.48E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.76|P-value:1.08E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.58|P-value:1.57E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.13|P-value:2.37E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.52|P-value:2.43E-8 ID:SGTC_1781|Compound:st038725|FD-Score:3.86|P-value:7.10E-5 ID:SGTC_2053|Compound:5265679|FD-Score:5.20|P-value:1.40E-7 ID:SGTC_2054|Compound:5233173|FD-Score:4.24|P-value:1.49E-5 ID:SGTC_2060|Compound:5238662|FD-Score:5.83|P-value:4.13E-9 ID:SGTC_2185|Compound:6113692|FD-Score:5.09|P-value:2.53E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.50|P-value:2.86E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.68|P-value:1.47E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.30|P-value:5.88E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_2474|Compound:5321570|FD-Score:4.73|P-value:1.53E-6 ID:SGTC_2478|Compound:5763493|FD-Score:3.57|P-value:2.25E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.60|P-value:1.45E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.33|P-value:6.69E-6 ID:SGTC_2521|Compound:angolensin|FD-Score:3.95|P-value:4.93E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.72|P-value:1.26E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.65|P-value:1.63E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.04|P-value:3.40E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.21|P-value:8.18E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.37|P-value:4.62E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.52|P-value:2.69E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.98|P-value:4.41E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.59|P-value:1.63E-8 ID:SGTC_3025|Compound:9087895|FD-Score:3.23|P-value:7.43E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.58|P-value:2.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.92|P-value:5.67E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.64|P-value:1.72E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.67|P-value:2.02E-11 ID:SGTC_3331|Compound:9141060|FD-Score:3.47|P-value:3.23E-4

Top fitness defect scores for YNL059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1189 1431-2119 9.24 7.3 µM 2.69E-20 2 1.24E-20
2 SGTC_951 1171-0579 8.15 82.7 µM 3.55E-16 cell wall 15 1.86E-16
3 SGTC_58 0957-0393 7.84 9.0 µM 4.07E-15 cell wall 130 2.20E-15
4 SGTC_586 0957-0265 7.58 8.2 µM 3.16E-14 cell wall 8 1.76E-14
5 SGTC_3311 9131146 6.67 2.9 µM 2.02E-11 cell wall 50 1.24E-11
6 SGTC_138 0850-0259 6.09 40.9 µM 8.42E-10 cell wall 102 5.48E-10
7 SGTC_241 5hr heat shock (37°C) + cantharidin 5.97 155.4 µM 1.85E-9 cell wall signaling 31 1.22E-9
8 SGTC_2060 5238662 5.83 140.0 µM 4.13E-9 8 2.76E-9
9 SGTC_7 0192-1582 5.64 4.2 µM 1.22E-8 28 8.27E-9
10 SGTC_2912 7964298 5.59 10.9 µM 1.63E-8 cell wall 55 1.11E-8
11 SGTC_1750 st081859 5.52 2.4 µM 2.43E-8 endomembrane recycling 119 1.67E-8
12 SGTC_266 formosanin C 5.44 406.0 nM 3.93E-8 sphingolipid biosynthesis & PDR1 37 2.71E-8
13 SGTC_2053 5265679 5.20 138.0 µM 1.40E-7 3 9.88E-8
14 SGTC_243 5hr heat shock (37°C) + splitomicin 5.17 1.0 µM 1.66E-7 heat shock/prefoldin 21 1.18E-7
15 SGTC_2185 6113692 5.09 200.0 µM 2.53E-7 ergosterol biosynthesis 4 1.80E-7
16 SGTC_1062 mesoridazine 5.03 14.2 µM 3.44E-7 5 2.46E-7
17 SGTC_641 4092-0595 4.77 30.0 µM 1.28E-6 8 9.34E-7
18 SGTC_2474 5321570 4.73 43.3 µM 1.53E-6 4 1.12E-6
19 SGTC_1276 0871-0068 4.63 94.2 µM 2.50E-6 12 1.85E-6
20 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.46 819.4 µM 5.43E-6 heat shock/prefoldin 26 4.08E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 1.65E-60 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.270 6.50E-57 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.257 1.41E-51 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.248 2.17E-48 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.229 5.90E-41 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.228 5.91E-41 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.227 2.22E-40 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.221 2.32E-38 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.220 4.85E-38 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.216 6.69E-37 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.212 1.84E-35 YBL062W_d YBL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.210 6.41E-35 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.210 1.11E-34 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.208 5.29E-34 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.202 2.38E-32 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria