YNL063W / MTQ1

S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL063W / MTQ1

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.13|P-value:9.79E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.49|P-value:2.74E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.29|P-value:1.03E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.40|P-value:3.85E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.58|P-value:1.92E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.34|P-value:3.88E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-4.04|P-value:2.53E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:4.23|P-value:1.37E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:5.43|P-value:3.55E-8 ID:SGTC_1159|Compound:4092-0538|FD-Score:-3.40|P-value:3.10E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.24|P-value:6.68E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.92|P-value:5.12E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.68|P-value:1.73E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.76|P-value:7.79E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.65|P-value:1.95E-6 ID:SGTC_2279|Compound:7948423|FD-Score:4.12|P-value:2.25E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.06|P-value:2.80E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-4.30|P-value:7.79E-6 ID:SGTC_2314|Compound:7727897|FD-Score:4.41|P-value:6.22E-6 ID:SGTC_2356|Compound:9061756|FD-Score:3.18|P-value:8.21E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.61|P-value:1.76E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.67|P-value:1.38E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.14|P-value:8.03E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.23|P-value:6.84E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.26|P-value:5.22E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-4.18|P-value:1.33E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.34|P-value:4.78E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.81|P-value:6.47E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.37|P-value:7.40E-6 ID:SGTC_3109|Compound:9122853|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_3347|Compound:9188721|FD-Score:8.06|P-value:5.24E-16 ID:SGTC_3348|Compound:9149464|FD-Score:-3.16|P-value:7.41E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.53|P-value:1.92E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.67|P-value:1.41E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.90|P-value:5.54E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:3.13|P-value:9.79E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.49|P-value:2.74E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.29|P-value:1.03E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.40|P-value:3.85E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.58|P-value:1.92E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.34|P-value:3.88E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-4.04|P-value:2.53E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:4.23|P-value:1.37E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:5.43|P-value:3.55E-8 ID:SGTC_1159|Compound:4092-0538|FD-Score:-3.40|P-value:3.10E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.24|P-value:6.68E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.92|P-value:5.12E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.68|P-value:1.73E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.76|P-value:7.79E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.65|P-value:1.95E-6 ID:SGTC_2279|Compound:7948423|FD-Score:4.12|P-value:2.25E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.06|P-value:2.80E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-4.30|P-value:7.79E-6 ID:SGTC_2314|Compound:7727897|FD-Score:4.41|P-value:6.22E-6 ID:SGTC_2356|Compound:9061756|FD-Score:3.18|P-value:8.21E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.61|P-value:1.76E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.67|P-value:1.38E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.14|P-value:8.03E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.23|P-value:6.84E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.26|P-value:5.22E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-4.18|P-value:1.33E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.34|P-value:4.78E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.81|P-value:6.47E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.37|P-value:7.40E-6 ID:SGTC_3109|Compound:9122853|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_3347|Compound:9188721|FD-Score:8.06|P-value:5.24E-16 ID:SGTC_3348|Compound:9149464|FD-Score:-3.16|P-value:7.41E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.53|P-value:1.92E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.67|P-value:1.41E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.90|P-value:5.54E-5

Top fitness defect scores for YNL063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3347 9188721 8.06 44.7 µM 5.24E-16 2 3.68E-16
2 SGTC_914 3820-6779 5.43 408.0 µM 3.55E-8 4 2.87E-8
3 SGTC_2126 5251174 4.68 33.9 µM 1.73E-6 13 1.46E-6
4 SGTC_2131 toluylene red 4.65 5.3 µM 1.95E-6 60S ribosome export 10 1.64E-6
5 SGTC_2314 7727897 4.41 200.0 µM 6.22E-6 11 5.28E-6
6 SGTC_3104 9120930 4.37 49.5 µM 7.40E-6 6 6.30E-6
7 SGTC_338 4055-0136 4.29 114.0 µM 1.03E-5 4 8.81E-6
8 SGTC_912 3474-0017 4.23 2.2 µM 1.37E-5 17 1.17E-5
9 SGTC_2279 7948423 4.12 32.9 µM 2.25E-5 11 1.93E-5
10 SGTC_2309 7664088 4.06 163.9 µM 2.80E-5 23 2.41E-5
11 SGTC_1953 st076800 3.92 12.1 µM 5.12E-5 50 4.44E-5
12 SGTC_3354 9151612 3.90 71.4 µM 5.54E-5 9 4.81E-5
13 SGTC_2452 5863136 3.67 48.4 µM 1.38E-4 32 1.21E-4
14 SGTC_3353 9151644 3.67 39.3 µM 1.41E-4 18 1.23E-4
15 SGTC_3109 9122853 3.64 49.5 µM 1.54E-4 11 1.35E-4
16 SGTC_3099 9120367 3.64 49.5 µM 1.57E-4 23 1.38E-4
17 SGTC_2368 9071271 3.61 200.0 µM 1.76E-4 46 1.54E-4
18 SGTC_628 1636-0253 3.58 16.0 µM 1.92E-4 sphingolipid biosynthesis & PDR1 45 1.69E-4
19 SGTC_168 3970-0862 3.49 530.5 µM 2.74E-4 157 2.42E-4
20 SGTC_358 0075-0058 3.40 9.4 µM 3.85E-4 92 3.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.59E-15 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.114 3.12E-11 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.101 4.23E-9 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.098 1.10E-8 YOR025W HST3 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.092 8.69E-8 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.089 2.71E-7 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.089 2.84E-7 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.086 6.04E-7 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.084 1.02E-6 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.084 1.24E-6 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.082 1.83E-6 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.080 3.27E-6 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.078 5.31E-6 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.078 7.01E-6 YOR332W VMA4 hom Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress
0.075 1.47E-5 YPR049C ATG11 hom Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)