YNL066W / SUN4

Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL066W / SUN4

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.00|P-value:2.42E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.05|P-value:6.07E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.10|P-value:7.64E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-4.00|P-value:1.25E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.89|P-value:3.85E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.90|P-value:2.95E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.11|P-value:7.41E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.81|P-value:5.52E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-2.93|P-value:9.49E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.46|P-value:2.28E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.83|P-value:5.07E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.39|P-value:3.01E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.12|P-value:7.96E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.23|P-value:3.18E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.25|P-value:2.91E-4 ID:SGTC_2019|Compound:4016004|FD-Score:5.05|P-value:1.27E-7 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.35|P-value:3.45E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.06|P-value:1.85E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-2.94|P-value:8.94E-4 ID:SGTC_2186|Compound:6124449|FD-Score:-3.07|P-value:5.56E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.23|P-value:5.47E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.50|P-value:1.09E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.29|P-value:3.29E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.33|P-value:2.59E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.66|P-value:1.02E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.18|P-value:1.05E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.50|P-value:1.07E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.25|P-value:5.10E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.85|P-value:3.85E-7 ID:SGTC_3131|Compound:9127911|FD-Score:4.27|P-value:6.98E-6 ID:SGTC_3139|Compound:9095020|FD-Score:-3.59|P-value:7.30E-5 ID:SGTC_3141|Compound:9094609|FD-Score:4.48|P-value:2.49E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.08|P-value:9.09E-4 ID:SGTC_3187|Compound:9109394|FD-Score:7.32|P-value:2.98E-14 ID:SGTC_3226|Compound:9131256|FD-Score:-3.11|P-value:4.93E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.15|P-value:4.27E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.00|P-value:2.42E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.05|P-value:6.07E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.10|P-value:7.64E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-4.00|P-value:1.25E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.89|P-value:3.85E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.90|P-value:2.95E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.11|P-value:7.41E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.81|P-value:5.52E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-2.93|P-value:9.49E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.46|P-value:2.28E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.83|P-value:5.07E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.39|P-value:3.01E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.12|P-value:7.96E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.23|P-value:3.18E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.25|P-value:2.91E-4 ID:SGTC_2019|Compound:4016004|FD-Score:5.05|P-value:1.27E-7 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.35|P-value:3.45E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.06|P-value:1.85E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-2.94|P-value:8.94E-4 ID:SGTC_2186|Compound:6124449|FD-Score:-3.07|P-value:5.56E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.23|P-value:5.47E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.50|P-value:1.09E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.29|P-value:3.29E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.33|P-value:2.59E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.66|P-value:1.02E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.18|P-value:1.05E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.50|P-value:1.07E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.25|P-value:5.10E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.85|P-value:3.85E-7 ID:SGTC_3131|Compound:9127911|FD-Score:4.27|P-value:6.98E-6 ID:SGTC_3139|Compound:9095020|FD-Score:-3.59|P-value:7.30E-5 ID:SGTC_3141|Compound:9094609|FD-Score:4.48|P-value:2.49E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.08|P-value:9.09E-4 ID:SGTC_3187|Compound:9109394|FD-Score:7.32|P-value:2.98E-14 ID:SGTC_3226|Compound:9131256|FD-Score:-3.11|P-value:4.93E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.15|P-value:4.27E-4

Top fitness defect scores for YNL066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3187 9109394 7.32 49.5 µM 2.98E-14 Golgi 1 1.20E-13
2 SGTC_2565 isoliquiritigenin 5.29 100.0 µM 3.29E-8 16 6.12E-8
3 SGTC_2019 4016004 5.05 108.0 µM 1.27E-7 7 2.21E-7
4 SGTC_635 k038-0028 4.90 24.7 µM 2.95E-7 ubiquinone biosynthesis & proteasome 29 4.89E-7
5 SGTC_2798 7813637 4.85 45.5 µM 3.85E-7 12 6.30E-7
6 SGTC_3141 9094609 4.48 49.5 µM 2.49E-6 iron homeostasis 26 3.70E-6
7 SGTC_3131 9127911 4.27 49.5 µM 6.98E-6 21 9.85E-6
8 SGTC_2660 2',4'-dihydroxychalcone 4.18 17.1 µM 1.05E-5 14 1.46E-5
9 SGTC_2106 5357045 4.06 167.3 µM 1.85E-5 15 2.49E-5
10 SGTC_40 0327-0103 4.00 19.8 µM 2.42E-5 30 3.21E-5
11 SGTC_557 1315-0110 3.89 16.2 µM 3.85E-5 Golgi 23 5.00E-5
12 SGTC_1509 1326-1131 3.83 80.0 µM 5.07E-5 14 6.49E-5
13 SGTC_936 3005-4620 3.81 401.0 µM 5.52E-5 25 7.04E-5
14 SGTC_2654 protoveratrine a 3.66 100.0 µM 1.01E-4 11 1.25E-4
15 SGTC_2589 lobaric acid 3.66 100.0 µM 1.02E-4 30 1.26E-4
16 SGTC_424 splitomicin 3.58 100.0 mM 1.40E-4 28 1.71E-4
17 SGTC_1045 1348-1485 3.46 165.0 µM 2.28E-4 54 2.73E-4
18 SGTC_1575 cyproterone acetate 3.39 48.0 µM 3.01E-4 40 3.54E-4
19 SGTC_2039 Aminomethylbenzodioxan 3.35 200.0 µM 3.45E-4 16 4.04E-4
20 SGTC_2043 5101342 3.32 149.0 µM 3.84E-4 SWF1 & branched chain AA biosynthesis 40 4.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.42E-9 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.096 2.61E-8 YPR155C NCA2 hom Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
0.094 4.24E-8 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.084 9.70E-7 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.084 1.12E-6 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.081 2.35E-6 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.081 2.81E-6 YNR073C_p YNR073C_p hom Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
0.078 6.78E-6 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.076 9.23E-6 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.075 1.29E-5 YKR074W AIM29 hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
0.075 1.38E-5 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.074 1.96E-5 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.072 2.96E-5 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.071 4.32E-5 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.070 4.61E-5 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress