YNL068C / FKH2

Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL068C / FKH2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.22|P-value:8.64E-19 ID:SGTC_138|Compound:0850-0259|FD-Score:5.43|P-value:3.35E-9 ID:SGTC_230|Compound:MPP+|FD-Score:2.95|P-value:8.03E-4 ID:SGTC_442|Compound:cape|FD-Score:3.02|P-value:6.35E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.51|P-value:8.79E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.06|P-value:7.39E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.75|P-value:3.05E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:2.95|P-value:8.20E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.65|P-value:4.87E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:4.60|P-value:4.51E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:2.93|P-value:8.90E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:2.95|P-value:8.23E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.40|P-value:1.32E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:5.19|P-value:1.52E-8 ID:SGTC_937|Compound:3122-0005|FD-Score:3.84|P-value:2.07E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.06|P-value:5.37E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.03|P-value:8.25E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.74|P-value:3.30E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.53|P-value:8.32E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.84|P-value:2.04E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.48|P-value:8.45E-7 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:2.91|P-value:9.59E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.13|P-value:4.15E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.44|P-value:1.17E-4 ID:SGTC_1655|Compound:st012546|FD-Score:2.97|P-value:7.51E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.16|P-value:3.67E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.61|P-value:5.87E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.01|P-value:6.44E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.80|P-value:2.48E-5 ID:SGTC_1725|Compound:st036284|FD-Score:2.98|P-value:7.28E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.66|P-value:7.66E-10 ID:SGTC_1728|Compound:st035614|FD-Score:4.02|P-value:8.93E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.00|P-value:6.79E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.99|P-value:6.98E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.55|P-value:7.51E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.28|P-value:2.31E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.09|P-value:4.82E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.07|P-value:6.99E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-2.94|P-value:8.58E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.30|P-value:2.13E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.49|P-value:9.61E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.13|P-value:4.19E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.84|P-value:2.08E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.30|P-value:2.15E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.00|P-value:6.68E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.72|P-value:3.54E-5 ID:SGTC_3133|Compound:9127736|FD-Score:2.91|P-value:9.30E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-4.34|P-value:1.74E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.68|P-value:4.29E-5 ID:SGTC_3216|Compound:9129716|FD-Score:5.96|P-value:9.50E-11 ID:SGTC_3222|Compound:9128301|FD-Score:-3.85|P-value:1.96E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.54|P-value:7.71E-5 ID:SGTC_3309|Compound:9129340|FD-Score:-3.02|P-value:6.36E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.22|P-value:8.64E-19 ID:SGTC_138|Compound:0850-0259|FD-Score:5.43|P-value:3.35E-9 ID:SGTC_230|Compound:MPP+|FD-Score:2.95|P-value:8.03E-4 ID:SGTC_442|Compound:cape|FD-Score:3.02|P-value:6.35E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.51|P-value:8.79E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.06|P-value:7.39E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.75|P-value:3.05E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:2.95|P-value:8.20E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.65|P-value:4.87E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:4.60|P-value:4.51E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:2.93|P-value:8.90E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:2.95|P-value:8.23E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.40|P-value:1.32E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:5.19|P-value:1.52E-8 ID:SGTC_937|Compound:3122-0005|FD-Score:3.84|P-value:2.07E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.06|P-value:5.37E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.03|P-value:8.25E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.74|P-value:3.30E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.53|P-value:8.32E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.84|P-value:2.04E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.48|P-value:8.45E-7 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:2.91|P-value:9.59E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.13|P-value:4.15E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.44|P-value:1.17E-4 ID:SGTC_1655|Compound:st012546|FD-Score:2.97|P-value:7.51E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.16|P-value:3.67E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.61|P-value:5.87E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.01|P-value:6.44E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.80|P-value:2.48E-5 ID:SGTC_1725|Compound:st036284|FD-Score:2.98|P-value:7.28E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.66|P-value:7.66E-10 ID:SGTC_1728|Compound:st035614|FD-Score:4.02|P-value:8.93E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.00|P-value:6.79E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.99|P-value:6.98E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.55|P-value:7.51E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.28|P-value:2.31E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.09|P-value:4.82E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.07|P-value:6.99E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-2.94|P-value:8.58E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.30|P-value:2.13E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.49|P-value:9.61E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.13|P-value:4.19E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.84|P-value:2.08E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.30|P-value:2.15E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.00|P-value:6.68E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.72|P-value:3.54E-5 ID:SGTC_3133|Compound:9127736|FD-Score:2.91|P-value:9.30E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-4.34|P-value:1.74E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.68|P-value:4.29E-5 ID:SGTC_3216|Compound:9129716|FD-Score:5.96|P-value:9.50E-11 ID:SGTC_3222|Compound:9128301|FD-Score:-3.85|P-value:1.96E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.54|P-value:7.71E-5 ID:SGTC_3309|Compound:9129340|FD-Score:-3.02|P-value:6.36E-4

Top fitness defect scores for YNL068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.22 9.0 µM 8.64E-19 cell wall 114 1.06E-16
2 SGTC_3216 9129716 5.96 49.5 µM 9.50E-11 RPP1 & pyrimidine depletion 7 1.23E-9
3 SGTC_1727 st034309 5.66 9.9 µM 7.66E-10 11 7.72E-9
4 SGTC_138 0850-0259 5.43 40.9 µM 3.35E-9 cell wall 128 2.83E-8
5 SGTC_912 3474-0017 5.19 2.2 µM 1.52E-8 10 1.07E-7
6 SGTC_806 3966-4455 4.60 5.9 µM 4.51E-7 9 2.12E-6
7 SGTC_1354 1498-1681 4.48 81.0 µM 8.45E-7 9 3.68E-6
8 SGTC_859 0439-0102 4.40 54.6 µM 1.32E-6 redox potentiating 12 5.45E-6
9 SGTC_2524 avocatin b 4.07 10.6 µM 6.99E-6 22 2.37E-5
10 SGTC_514 4466-0038 4.06 2.6 nM 7.39E-6 cell wall 147 2.49E-5
11 SGTC_1099 5-nonyloxytryptamine 4.03 2.9 µM 8.25E-6 17 2.75E-5
12 SGTC_1728 st035614 4.02 33.8 µM 8.93E-6 44 2.94E-5
13 SGTC_1331 1472-0049 3.84 76.2 µM 2.04E-5 21 6.10E-5
14 SGTC_937 3122-0005 3.84 46.7 µM 2.07E-5 27 6.19E-5
15 SGTC_2751 anetholtrithion 3.84 17.2 µM 2.08E-5 28 6.22E-5
16 SGTC_1712 st032288 3.80 53.4 µM 2.48E-5 calcium & mitochondrial duress 197 7.24E-5
17 SGTC_528 3492-0019 3.75 172.0 µM 3.05E-5 calcium & mitochondrial duress 236 8.70E-5
18 SGTC_1115 galangin 3.74 695.7 nM 3.30E-5 RPP1 & pyrimidine depletion 21 9.34E-5
19 SGTC_3093 9117344 3.72 49.5 µM 3.54E-5 60S ribosome export 22 9.94E-5
20 SGTC_3202 9113761 3.68 49.5 µM 4.29E-5 57 1.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.300 1.33E-70 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.261 1.78E-53 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.258 4.03E-52 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.257 8.27E-52 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.250 5.61E-49 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.244 1.52E-46 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.240 2.57E-45 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.239 1.12E-44 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.236 9.47E-44 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.230 1.82E-41 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.227 1.66E-40 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.226 5.37E-40 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.225 9.21E-40 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.225 1.10E-39 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.225 1.14E-39 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication