YNL069C / RPL16B

Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL069C / RPL16B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.35|P-value:4.53E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:4.41|P-value:3.50E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.69|P-value:4.45E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.76|P-value:3.49E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.34|P-value:6.94E-7 ID:SGTC_375|Compound:3970-0961|FD-Score:3.77|P-value:3.38E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.86|P-value:2.43E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.28|P-value:5.87E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.79|P-value:3.16E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.80|P-value:3.12E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.28|P-value:5.85E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:4.22|P-value:7.30E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.57|P-value:1.94E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.58|P-value:1.86E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.63|P-value:5.49E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.71|P-value:1.08E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.50|P-value:8.23E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.73|P-value:3.89E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.41|P-value:3.50E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.06|P-value:1.27E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.54|P-value:2.16E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.06|P-value:1.21E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.01|P-value:1.42E-4 ID:SGTC_1688|Compound:st021091|FD-Score:4.04|P-value:1.35E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.55|P-value:6.85E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.44|P-value:9.80E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.62|P-value:5.51E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.56|P-value:6.28E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.05|P-value:1.34E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.93|P-value:1.99E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.40|P-value:3.45E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.83|P-value:2.83E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.48|P-value:8.27E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.64|P-value:4.95E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.30|P-value:5.08E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.63|P-value:3.05E-12 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.34|P-value:4.31E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.47|P-value:2.79E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.48|P-value:2.69E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.10|P-value:1.10E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.76|P-value:8.94E-6 ID:SGTC_2972|Compound:9093619|FD-Score:3.47|P-value:8.88E-4 ID:SGTC_2975|Compound:9084847|FD-Score:5.20|P-value:1.40E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.98|P-value:1.57E-4 ID:SGTC_3235|Compound:9132602|FD-Score:5.42|P-value:5.21E-7 ID:SGTC_3237|Compound:9133362|FD-Score:-3.54|P-value:6.72E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.48|P-value:8.09E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.35|P-value:4.53E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:4.41|P-value:3.50E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.69|P-value:4.45E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.76|P-value:3.49E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.34|P-value:6.94E-7 ID:SGTC_375|Compound:3970-0961|FD-Score:3.77|P-value:3.38E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.86|P-value:2.43E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.28|P-value:5.87E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.79|P-value:3.16E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.80|P-value:3.12E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.28|P-value:5.85E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:4.22|P-value:7.30E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.57|P-value:1.94E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.58|P-value:1.86E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.63|P-value:5.49E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.71|P-value:1.08E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.50|P-value:8.23E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.73|P-value:3.89E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.41|P-value:3.50E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.06|P-value:1.27E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.54|P-value:2.16E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.06|P-value:1.21E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.01|P-value:1.42E-4 ID:SGTC_1688|Compound:st021091|FD-Score:4.04|P-value:1.35E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.55|P-value:6.85E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.44|P-value:9.80E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.62|P-value:5.51E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.56|P-value:6.28E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.05|P-value:1.34E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.93|P-value:1.99E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.40|P-value:3.45E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.83|P-value:2.83E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.48|P-value:8.27E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.64|P-value:4.95E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.30|P-value:5.08E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.63|P-value:3.05E-12 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.34|P-value:4.31E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.47|P-value:2.79E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.48|P-value:2.69E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.10|P-value:1.10E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.76|P-value:8.94E-6 ID:SGTC_2972|Compound:9093619|FD-Score:3.47|P-value:8.88E-4 ID:SGTC_2975|Compound:9084847|FD-Score:5.20|P-value:1.40E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.98|P-value:1.57E-4 ID:SGTC_3235|Compound:9132602|FD-Score:5.42|P-value:5.21E-7 ID:SGTC_3237|Compound:9133362|FD-Score:-3.54|P-value:6.72E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.48|P-value:8.09E-4

Top fitness defect scores for YNL069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 7.63 3.5 µM 3.05E-12 17 1.20E-14
2 SGTC_3235 9132602 5.42 49.5 µM 5.21E-7 7 3.00E-8
3 SGTC_2975 9084847 5.20 53.7 µM 1.40E-6 5 1.00E-7
4 SGTC_2826 7992541 4.76 19.5 µM 8.94E-6 8 9.63E-7
5 SGTC_870 0573-2213 4.71 57.6 µM 1.08E-5 ERG2 9 1.22E-6
6 SGTC_832 4083-0019 4.58 164.0 µM 1.86E-5 translation 60 2.36E-6
7 SGTC_800 3448-7362 4.57 155.0 µM 1.94E-5 translation 113 2.48E-6
8 SGTC_1218 1348-1416 4.54 30.7 µM 2.16E-5 SWF1 & branched chain AA biosynthesis 7 2.82E-6
9 SGTC_2687 chenodiol 4.48 100.0 µM 2.69E-5 14 3.68E-6
10 SGTC_2582 agaric acid 4.47 100.0 µM 2.79E-5 redox potentiating 261 3.85E-6
11 SGTC_129 0088-0017 4.41 176.6 µM 3.50E-5 59 5.07E-6
12 SGTC_1094 duloxetine 4.41 25.4 µM 3.50E-5 RPP1 & pyrimidine depletion 8 5.08E-6
13 SGTC_118 0083-0097 4.35 135.3 µM 4.53E-5 translation 99 6.95E-6
14 SGTC_599 1935-0052 4.28 86.5 µM 5.85E-5 14 9.49E-6
15 SGTC_392 N-ethylmaleimide 4.28 8.3 µM 5.87E-5 RNA pol III & RNase P/MRP 10 9.54E-6
16 SGTC_616 4092-0450 4.22 108.0 µM 7.30E-5 9 1.24E-5
17 SGTC_2760 etidronate 4.10 98.0 µM 1.10E-4 22 2.04E-5
18 SGTC_1147 3809-1045 4.06 12.3 µM 1.27E-4 22 2.44E-5
19 SGTC_1983 st071813 4.05 46.9 µM 1.34E-4 RPP1 & pyrimidine depletion 16 2.60E-5
20 SGTC_1688 st021091 4.04 57.6 µM 1.35E-4 5 2.63E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.219 1.73E-37 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.127 1.76E-13 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.112 6.94E-11 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.110 2.06E-10 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.103 2.15E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.102 2.87E-9 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.102 3.46E-9 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.099 9.07E-9 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.099 1.07E-8 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.098 1.38E-8 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.097 1.52E-8 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.097 1.69E-8 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.094 4.66E-8 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.094 5.24E-8 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.092 8.03E-8 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal