YNL071W / LAT1

Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL071W / LAT1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:8.65|P-value:3.79E-17 ID:SGTC_34|Compound:0469-0683|FD-Score:5.30|P-value:1.82E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.91|P-value:6.29E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:5.05|P-value:6.24E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:12.90|P-value:1.04E-35 ID:SGTC_163|Compound:1327-0036|FD-Score:7.49|P-value:2.77E-13 ID:SGTC_263|Compound:alizarin|FD-Score:5.72|P-value:1.93E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:4.50|P-value:8.00E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.96|P-value:7.46E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.63|P-value:1.85E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.47|P-value:4.54E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.54|P-value:3.56E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.47|P-value:4.53E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.18|P-value:3.15E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.16|P-value:3.36E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.13|P-value:4.16E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:6.30|P-value:6.88E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.57|P-value:5.77E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:5.19|P-value:3.16E-7 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.66|P-value:2.65E-8 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.56|P-value:3.32E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.63|P-value:2.61E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.29|P-value:8.32E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.48|P-value:8.54E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-4.08|P-value:3.22E-5 ID:SGTC_1843|Compound:st055809|FD-Score:-3.33|P-value:5.41E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.23|P-value:2.49E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.36|P-value:6.55E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-3.45|P-value:3.49E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.42|P-value:5.42E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.67|P-value:2.27E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.25|P-value:6.97E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.63|P-value:4.42E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.33|P-value:5.34E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:8.10|P-value:2.97E-15 ID:SGTC_2414|Compound:st077232|FD-Score:4.77|P-value:2.37E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:18.50|P-value:9.34E-72 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.99|P-value:6.68E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.56|P-value:5.97E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.05|P-value:5.25E-5 ID:SGTC_2821|Compound:7996764|FD-Score:6.12|P-value:1.99E-9 ID:SGTC_2895|Compound:9054447|FD-Score:3.78|P-value:1.50E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.72|P-value:1.84E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.80|P-value:9.69E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-3.67|P-value:1.56E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.07|P-value:4.75E-5 ID:SGTC_3299|Compound:9121982|FD-Score:5.57|P-value:4.30E-8 ID:SGTC_3315|Compound:9136395|FD-Score:3.29|P-value:8.23E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:8.65|P-value:3.79E-17 ID:SGTC_34|Compound:0469-0683|FD-Score:5.30|P-value:1.82E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.91|P-value:6.29E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:5.05|P-value:6.24E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:12.90|P-value:1.04E-35 ID:SGTC_163|Compound:1327-0036|FD-Score:7.49|P-value:2.77E-13 ID:SGTC_263|Compound:alizarin|FD-Score:5.72|P-value:1.93E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:4.50|P-value:8.00E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.96|P-value:7.46E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.63|P-value:1.85E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.47|P-value:4.54E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.54|P-value:3.56E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.47|P-value:4.53E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.18|P-value:3.15E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.16|P-value:3.36E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.13|P-value:4.16E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:6.30|P-value:6.88E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.57|P-value:5.77E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:5.19|P-value:3.16E-7 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.66|P-value:2.65E-8 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.56|P-value:3.32E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.63|P-value:2.61E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.29|P-value:8.32E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.48|P-value:8.54E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-4.08|P-value:3.22E-5 ID:SGTC_1843|Compound:st055809|FD-Score:-3.33|P-value:5.41E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.23|P-value:2.49E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.36|P-value:6.55E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-3.45|P-value:3.49E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.42|P-value:5.42E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.67|P-value:2.27E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.25|P-value:6.97E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.63|P-value:4.42E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.33|P-value:5.34E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:8.10|P-value:2.97E-15 ID:SGTC_2414|Compound:st077232|FD-Score:4.77|P-value:2.37E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:18.50|P-value:9.34E-72 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.99|P-value:6.68E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.56|P-value:5.97E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.05|P-value:5.25E-5 ID:SGTC_2821|Compound:7996764|FD-Score:6.12|P-value:1.99E-9 ID:SGTC_2895|Compound:9054447|FD-Score:3.78|P-value:1.50E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.72|P-value:1.84E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.80|P-value:9.69E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-3.67|P-value:1.56E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.07|P-value:4.75E-5 ID:SGTC_3299|Compound:9121982|FD-Score:5.57|P-value:4.30E-8 ID:SGTC_3315|Compound:9136395|FD-Score:3.29|P-value:8.23E-4

Top fitness defect scores for YNL071W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2417 cerulenin 18.50 830.0 nM 9.34E-72 1 1.23E-76
2 SGTC_59 0330-0160 12.90 1.3 µM 1.04E-35 6 3.76E-38
3 SGTC_7 0192-1582 8.65 4.2 µM 3.79E-17 11 2.58E-18
4 SGTC_2410 aloe-emodin-8-o-glycoside 8.10 46.3 µM 2.97E-15 mitochondrial processes 1 2.74E-16
5 SGTC_163 1327-0036 7.49 7.5 µM 2.77E-13 22 3.50E-14
6 SGTC_1123 mangostin 6.30 811.3 nM 6.88E-10 mitochondrial response to ROS 10 1.51E-10
7 SGTC_2821 7996764 6.12 71.4 µM 1.99E-9 5 4.70E-10
8 SGTC_263 alizarin 5.72 107.9 µM 1.93E-8 iron homeostasis 29 5.36E-9
9 SGTC_1163 k060-0048 5.66 49.9 µM 2.65E-8 6 7.54E-9
10 SGTC_3299 9121982 5.57 43.1 µM 4.30E-8 7 1.27E-8
11 SGTC_34 0469-0683 5.30 81.8 µM 1.82E-7 SWF1 & branched chain AA biosynthesis 14 5.93E-8
12 SGTC_1147 3809-1045 5.19 12.3 µM 3.16E-7 4 1.07E-7
13 SGTC_1122 capsaicin 5.13 818.6 nM 4.16E-7 11 1.44E-7
14 SGTC_54 0159-0055 5.05 9.0 µM 6.24E-7 ERG2 29 2.22E-7
15 SGTC_2414 st077232 4.77 92.9 µM 2.37E-6 10 9.29E-7
16 SGTC_2350 9023895 4.63 38.9 µM 4.42E-6 ergosterol biosynthesis 19 1.81E-6
17 SGTC_1134 3477-0009 4.57 42.5 µM 5.77E-6 30 2.41E-6
18 SGTC_2651 1327-0036 4.56 5.0 µM 5.97E-6 132 2.50E-6
19 SGTC_266 formosanin C 4.50 406.0 nM 8.00E-6 sphingolipid biosynthesis & PDR1 54 3.42E-6
20 SGTC_1287 0971-0001 4.48 34.6 µM 8.54E-6 sphingolipid biosynthesis & PDR1 37 3.67E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.281 7.39E-62 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.256 3.12E-51 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.246 2.77E-47 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.245 3.72E-47 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.174 3.91E-24 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.146 1.78E-17 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.143 1.03E-16 YLR436C ECM30 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.142 1.21E-16 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.141 2.31E-16 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.141 2.33E-16 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.140 3.25E-16 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.139 6.26E-16 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.136 2.06E-15 YOR196C LIP5 hom Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.136 2.17E-15 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.135 3.52E-15 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups