YNL079C / TPM1

Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL079C / TPM1

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:3.68|P-value:2.36E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.30|P-value:2.26E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:4.41|P-value:1.40E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.59|P-value:6.78E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.42|P-value:6.90E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.31|P-value:8.31E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.95|P-value:2.38E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:5.54|P-value:7.51E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.82|P-value:1.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.18|P-value:1.93E-18 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.03|P-value:9.42E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:3.29|P-value:8.66E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:5.55|P-value:7.16E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:3.70|P-value:2.22E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:7.03|P-value:1.46E-11 ID:SGTC_354|Compound:2783-3500|FD-Score:4.28|P-value:2.47E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.13|P-value:4.36E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:5.38|P-value:1.74E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:4.36|P-value:1.74E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.20|P-value:4.09E-7 ID:SGTC_447|Compound:ml7|FD-Score:3.79|P-value:1.57E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.51|P-value:4.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.41|P-value:7.16E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.50|P-value:4.33E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:6.08|P-value:4.20E-9 ID:SGTC_535|Compound:2293-4129|FD-Score:6.07|P-value:4.57E-9 ID:SGTC_582|Compound:0987-0078|FD-Score:4.36|P-value:1.74E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.40|P-value:1.50E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.46|P-value:5.00E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.38|P-value:1.74E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.35|P-value:1.82E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.49|P-value:4.50E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.36|P-value:7.04E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:5.08|P-value:7.44E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.67|P-value:2.47E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.61|P-value:2.99E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.85|P-value:1.59E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.14|P-value:4.31E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.60|P-value:3.80E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.32|P-value:7.93E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.81|P-value:1.46E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.60|P-value:6.32E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.06|P-value:4.70E-9 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.54|P-value:7.48E-8 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.29|P-value:2.70E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.66|P-value:2.52E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.38|P-value:1.64E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.46|P-value:4.98E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.55|P-value:3.68E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.35|P-value:2.03E-7 ID:SGTC_1734|Compound:st037168|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.25|P-value:3.47E-12 ID:SGTC_1760|Compound:st045453|FD-Score:9.42|P-value:2.74E-19 ID:SGTC_1780|Compound:st038448|FD-Score:3.33|P-value:7.70E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.12|P-value:6.20E-7 ID:SGTC_1800|Compound:st050079|FD-Score:3.36|P-value:7.07E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.36|P-value:1.84E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.84|P-value:1.58E-8 ID:SGTC_1809|Compound:st050081|FD-Score:3.34|P-value:7.49E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.55|P-value:3.65E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.53|P-value:3.99E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.48|P-value:5.75E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.65|P-value:2.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.32|P-value:1.11E-9 ID:SGTC_2013|Compound:4024628|FD-Score:4.79|P-value:2.83E-6 ID:SGTC_2021|Compound:4019055|FD-Score:5.64|P-value:4.66E-8 ID:SGTC_2030|Compound:5175110|FD-Score:3.32|P-value:8.02E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.44|P-value:5.35E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.42|P-value:5.67E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.58|P-value:3.37E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.90|P-value:3.31E-11 ID:SGTC_2265|Compound:7929201|FD-Score:3.46|P-value:5.09E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.97|P-value:1.03E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.20|P-value:3.32E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.95|P-value:8.91E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.91|P-value:1.58E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.26|P-value:9.61E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.07|P-value:7.53E-7 ID:SGTC_2702|Compound:st077768|FD-Score:3.29|P-value:8.90E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.92|P-value:9.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.41|P-value:5.96E-4 ID:SGTC_2912|Compound:7964298|FD-Score:12.30|P-value:2.46E-31 ID:SGTC_2926|Compound:9010726|FD-Score:3.71|P-value:2.13E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.73|P-value:1.98E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.23|P-value:2.91E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.52|P-value:4.09E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.66|P-value:4.90E-6 ID:SGTC_3168|Compound:9103419|FD-Score:-3.42|P-value:6.91E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.54|P-value:3.80E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.85|P-value:1.28E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.68|P-value:2.36E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.30|P-value:2.26E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:4.41|P-value:1.40E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.59|P-value:6.78E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.42|P-value:6.90E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.31|P-value:8.31E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.95|P-value:2.38E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:5.54|P-value:7.51E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.82|P-value:1.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.18|P-value:1.93E-18 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.03|P-value:9.42E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:3.29|P-value:8.66E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:5.55|P-value:7.16E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:3.70|P-value:2.22E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:7.03|P-value:1.46E-11 ID:SGTC_354|Compound:2783-3500|FD-Score:4.28|P-value:2.47E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.13|P-value:4.36E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:5.38|P-value:1.74E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:4.36|P-value:1.74E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.20|P-value:4.09E-7 ID:SGTC_447|Compound:ml7|FD-Score:3.79|P-value:1.57E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.51|P-value:4.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.41|P-value:7.16E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.50|P-value:4.33E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:6.08|P-value:4.20E-9 ID:SGTC_535|Compound:2293-4129|FD-Score:6.07|P-value:4.57E-9 ID:SGTC_582|Compound:0987-0078|FD-Score:4.36|P-value:1.74E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.40|P-value:1.50E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.46|P-value:5.00E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.38|P-value:1.74E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.35|P-value:1.82E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.49|P-value:4.50E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.36|P-value:7.04E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:5.08|P-value:7.44E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.67|P-value:2.47E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.61|P-value:2.99E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.85|P-value:1.59E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.14|P-value:4.31E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.60|P-value:3.80E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.32|P-value:7.93E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.81|P-value:1.46E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.60|P-value:6.32E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.06|P-value:4.70E-9 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.54|P-value:7.48E-8 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.29|P-value:2.70E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.66|P-value:2.52E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.38|P-value:1.64E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.46|P-value:4.98E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.55|P-value:3.68E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.35|P-value:2.03E-7 ID:SGTC_1734|Compound:st037168|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.25|P-value:3.47E-12 ID:SGTC_1760|Compound:st045453|FD-Score:9.42|P-value:2.74E-19 ID:SGTC_1780|Compound:st038448|FD-Score:3.33|P-value:7.70E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.12|P-value:6.20E-7 ID:SGTC_1800|Compound:st050079|FD-Score:3.36|P-value:7.07E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.36|P-value:1.84E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.84|P-value:1.58E-8 ID:SGTC_1809|Compound:st050081|FD-Score:3.34|P-value:7.49E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.55|P-value:3.65E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.53|P-value:3.99E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.48|P-value:5.75E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.65|P-value:2.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.32|P-value:1.11E-9 ID:SGTC_2013|Compound:4024628|FD-Score:4.79|P-value:2.83E-6 ID:SGTC_2021|Compound:4019055|FD-Score:5.64|P-value:4.66E-8 ID:SGTC_2030|Compound:5175110|FD-Score:3.32|P-value:8.02E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.44|P-value:5.35E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.42|P-value:5.67E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.58|P-value:3.37E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.90|P-value:3.31E-11 ID:SGTC_2265|Compound:7929201|FD-Score:3.46|P-value:5.09E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.97|P-value:1.03E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.20|P-value:3.32E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.95|P-value:8.91E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.91|P-value:1.58E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.26|P-value:9.61E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.07|P-value:7.53E-7 ID:SGTC_2702|Compound:st077768|FD-Score:3.29|P-value:8.90E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.92|P-value:9.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.41|P-value:5.96E-4 ID:SGTC_2912|Compound:7964298|FD-Score:12.30|P-value:2.46E-31 ID:SGTC_2926|Compound:9010726|FD-Score:3.71|P-value:2.13E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.73|P-value:1.98E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.23|P-value:2.91E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.52|P-value:4.09E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.66|P-value:4.90E-6 ID:SGTC_3168|Compound:9103419|FD-Score:-3.42|P-value:6.91E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.54|P-value:3.80E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.85|P-value:1.28E-4

Top fitness defect scores for YNL079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2912 7964298 12.30 10.9 µM 2.46E-31 cell wall 11 7.20E-35
2 SGTC_1760 st045453 9.42 10.4 µM 2.74E-19 NEO1-PIK1 36 2.35E-21
3 SGTC_221 trifluoperazine 9.18 10.3 µM 1.93E-18 NEO1-PIK1 71 2.09E-20
4 SGTC_1754 st042065 7.25 16.1 µM 3.47E-12 NEO1-PIK1 67 2.12E-13
5 SGTC_351 caspofungin 7.03 25.0 nM 1.46E-11 cell wall 26 1.06E-12
6 SGTC_137 0438-0332 6.95 85.4 µM 2.38E-11 ubiquinone biosynthesis & proteasome 51 1.83E-12
7 SGTC_2257 7960413 6.90 200.0 µM 3.31E-11 NEO1-PIK1 7 2.64E-12
8 SGTC_2006 4011487 6.32 200.0 µM 1.11E-9 endomembrane recycling 40 1.34E-10
9 SGTC_502 l-744,832 6.08 89.3 µM 4.20E-9 calcium & mitochondrial duress 10 5.95E-10
10 SGTC_535 2293-4129 6.07 48.2 µM 4.57E-9 NEO1 27 6.54E-10
11 SGTC_1230 0170-0365 6.06 3.8 µM 4.70E-9 endomembrane recycling 19 6.74E-10
12 SGTC_1803 st050068 5.84 52.4 µM 1.58E-8 NEO1-PIK1 89 2.61E-9
13 SGTC_2021 4019055 5.64 173.0 µM 4.66E-8 endomembrane recycling 49 8.73E-9
14 SGTC_313 3474-0040 5.55 5.0 µM 7.16E-8 NEO1-PIK1 29 1.41E-8
15 SGTC_1306 1185-0270 5.54 9.0 µM 7.48E-8 Golgi 33 1.48E-8
16 SGTC_138 0850-0259 5.54 40.9 µM 7.51E-8 cell wall 123 1.49E-8
17 SGTC_422 cantharidin 5.38 155.0 µM 1.74E-7 cell wall signaling 26 3.79E-8
18 SGTC_788 1182-0090 5.38 188.0 µM 1.74E-7 endomembrane recycling 45 3.80E-8
19 SGTC_1801 st050089 5.36 28.4 µM 1.84E-7 NEO1-PIK1 59 4.05E-8
20 SGTC_1712 st032288 5.35 53.4 µM 2.03E-7 calcium & mitochondrial duress 97 4.52E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.437 8.43E-156 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.386 6.00E-120 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.381 2.57E-116 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.380 9.49E-116 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.350 2.35E-97 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.342 1.84E-92 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.340 8.94E-92 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.330 4.74E-86 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.330 8.39E-86 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.329 1.43E-85 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.326 7.80E-84 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.322 5.47E-82 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.322 7.08E-82 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.315 5.65E-78 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.313 4.28E-77 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription