YNL081C / SWS2

Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL081C / SWS2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.67|P-value:1.91E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.59|P-value:7.81E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.93|P-value:3.04E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:8.05|P-value:1.57E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:4.18|P-value:2.86E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.30|P-value:6.51E-21 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:7.35E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.20|P-value:4.13E-28 ID:SGTC_294|Compound:k038-0071|FD-Score:-4.24|P-value:2.18E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-4.88|P-value:2.61E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:22.10|P-value:6.73E-75 ID:SGTC_314|Compound:1671-0008|FD-Score:5.21|P-value:8.99E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.95|P-value:2.06E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.00|P-value:4.93E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.17|P-value:2.97E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.08|P-value:1.41E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.99|P-value:5.06E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.59|P-value:1.78E-6 ID:SGTC_446|Compound:go6976|FD-Score:-4.22|P-value:2.35E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.88|P-value:6.36E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.93|P-value:2.41E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:4.15|P-value:3.18E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.78|P-value:3.65E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.29|P-value:2.09E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.59|P-value:7.72E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.65|P-value:6.31E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:4.40|P-value:1.45E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.92|P-value:6.25E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.85|P-value:3.26E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.30|P-value:5.52E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.48|P-value:1.03E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-8.45|P-value:1.34E-12 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.70|P-value:1.33E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:-4.01|P-value:4.43E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.61|P-value:7.45E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.15|P-value:3.19E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.91|P-value:6.43E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.30|P-value:1.97E-4 ID:SGTC_1623|Compound:st003709|FD-Score:6.08|P-value:2.72E-7 ID:SGTC_1742|Compound:st038235|FD-Score:5.55|P-value:2.39E-6 ID:SGTC_1972|Compound:st070201|FD-Score:4.59|P-value:7.72E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.22|P-value:2.54E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.11|P-value:3.31E-4 ID:SGTC_2016|Compound:5121758|FD-Score:11.00|P-value:7.06E-20 ID:SGTC_2020|Compound:4017018|FD-Score:5.38|P-value:4.68E-6 ID:SGTC_2021|Compound:4019055|FD-Score:-10.10|P-value:3.99E-17 ID:SGTC_2022|Compound:5136654|FD-Score:8.74|P-value:2.80E-13 ID:SGTC_2023|Compound:5144124|FD-Score:5.31|P-value:6.15E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.57|P-value:7.66E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.99|P-value:5.05E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.11|P-value:2.33E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.23|P-value:5.78E-12 ID:SGTC_2302|Compound:7771753|FD-Score:-4.29|P-value:1.88E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.12|P-value:1.24E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.17|P-value:1.04E-5 ID:SGTC_2570|Compound:licareol|FD-Score:5.65|P-value:1.60E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.09|P-value:3.84E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.83|P-value:3.08E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.85|P-value:3.21E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:2.33E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.00|P-value:4.91E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:3.90|P-value:6.64E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.79|P-value:8.39E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.62|P-value:6.49E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.01|P-value:4.44E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.86|P-value:6.73E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.88|P-value:2.65E-5 ID:SGTC_3118|Compound:9124250|FD-Score:-3.92|P-value:5.79E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.98|P-value:4.76E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.67|P-value:1.91E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.59|P-value:7.81E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.93|P-value:3.04E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:8.05|P-value:1.57E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:4.18|P-value:2.86E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.30|P-value:6.51E-21 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:7.35E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.20|P-value:4.13E-28 ID:SGTC_294|Compound:k038-0071|FD-Score:-4.24|P-value:2.18E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-4.88|P-value:2.61E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:22.10|P-value:6.73E-75 ID:SGTC_314|Compound:1671-0008|FD-Score:5.21|P-value:8.99E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.95|P-value:2.06E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.00|P-value:4.93E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.17|P-value:2.97E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.08|P-value:1.41E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.99|P-value:5.06E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.59|P-value:1.78E-6 ID:SGTC_446|Compound:go6976|FD-Score:-4.22|P-value:2.35E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.88|P-value:6.36E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.93|P-value:2.41E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:4.15|P-value:3.18E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.78|P-value:3.65E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.29|P-value:2.09E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.59|P-value:7.72E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.65|P-value:6.31E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:4.40|P-value:1.45E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.92|P-value:6.25E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.85|P-value:3.26E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.30|P-value:5.52E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.48|P-value:1.03E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-8.45|P-value:1.34E-12 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.70|P-value:1.33E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:-4.01|P-value:4.43E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.61|P-value:7.45E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.15|P-value:3.19E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.91|P-value:6.43E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.30|P-value:1.97E-4 ID:SGTC_1623|Compound:st003709|FD-Score:6.08|P-value:2.72E-7 ID:SGTC_1742|Compound:st038235|FD-Score:5.55|P-value:2.39E-6 ID:SGTC_1972|Compound:st070201|FD-Score:4.59|P-value:7.72E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.22|P-value:2.54E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.11|P-value:3.31E-4 ID:SGTC_2016|Compound:5121758|FD-Score:11.00|P-value:7.06E-20 ID:SGTC_2020|Compound:4017018|FD-Score:5.38|P-value:4.68E-6 ID:SGTC_2021|Compound:4019055|FD-Score:-10.10|P-value:3.99E-17 ID:SGTC_2022|Compound:5136654|FD-Score:8.74|P-value:2.80E-13 ID:SGTC_2023|Compound:5144124|FD-Score:5.31|P-value:6.15E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.57|P-value:7.66E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.99|P-value:5.05E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.11|P-value:2.33E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.23|P-value:5.78E-12 ID:SGTC_2302|Compound:7771753|FD-Score:-4.29|P-value:1.88E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.12|P-value:1.24E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.17|P-value:1.04E-5 ID:SGTC_2570|Compound:licareol|FD-Score:5.65|P-value:1.60E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.09|P-value:3.84E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.83|P-value:3.08E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.85|P-value:3.21E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:2.33E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.00|P-value:4.91E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:3.90|P-value:6.64E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.79|P-value:8.39E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.62|P-value:6.49E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.01|P-value:4.44E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.86|P-value:6.73E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.88|P-value:2.65E-5 ID:SGTC_3118|Compound:9124250|FD-Score:-3.92|P-value:5.79E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.98|P-value:4.76E-4

Top fitness defect scores for YNL081C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 22.10 1.1 µM 6.73E-75 mitochondrial stress 1 7.91E-109
2 SGTC_275 trichlorophene 13.20 5.7 µM 4.13E-28 mitochondrial stress 15 2.44E-40
3 SGTC_236 1509-0011 11.80 5.3 µM 7.35E-23 154 1.16E-32
4 SGTC_173 1273-0061 11.30 2.7 µM 6.51E-21 mitochondrial stress 31 8.18E-30
5 SGTC_2016 5121758 11.00 140.0 µM 7.06E-20 redox potentiating 2 2.66E-28
6 SGTC_2022 5136654 8.74 200.0 µM 2.80E-13 3 1.16E-18
7 SGTC_2250 alverine citrate 8.23 130.0 µM 5.78E-12 17 9.54E-17
8 SGTC_70 0141-0289 8.05 43.3 µM 1.57E-11 mitochondrial stress 40 4.10E-16
9 SGTC_63 0099-0242 7.93 26.7 µM 3.04E-11 mitochondrial stress 11 1.07E-15
10 SGTC_2232 chlorophetanol 7.11 41.5 µM 2.33E-9 TRP & mitochondrial translation 26 5.97E-13
11 SGTC_10 0279-0212 6.67 42.6 µM 1.91E-8 TRP & mitochondrial translation 20 1.28E-11
12 SGTC_1623 st003709 6.08 20.3 µM 2.72E-7 calcium & mitochondrial duress 13 6.05E-10
13 SGTC_1155 4088-0394 5.70 48.2 µM 1.33E-6 2 6.07E-9
14 SGTC_2570 licareol 5.65 100.0 µM 1.60E-6 6 7.93E-9
15 SGTC_1742 st038235 5.55 28.9 µM 2.39E-6 mitochondrial stress 59 1.41E-8
16 SGTC_2020 4017018 5.38 200.0 µM 4.68E-6 3 3.76E-8
17 SGTC_2023 5144124 5.31 124.0 µM 6.15E-6 4 5.57E-8
18 SGTC_314 1671-0008 5.21 2.7 µM 8.99E-6 17 9.66E-8
19 SGTC_2533 agelasine 5.17 13.7 µM 1.04E-5 ERG2 19 1.19E-7
20 SGTC_2526 patulin 5.12 37.6 µM 1.24E-5 45 1.54E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.512 8.01E-224 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.496 1.13E-207 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.479 2.39E-192 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.472 4.32E-185 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.467 9.88E-182 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.462 1.21E-176 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.453 3.30E-169 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.452 8.98E-169 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.448 3.23E-165 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.446 1.69E-163 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.433 2.11E-153 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.432 1.83E-152 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.429 4.94E-150 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.427 9.38E-149 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.427 2.58E-148 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene