YNL082W / PMS1

ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL082W / PMS1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.26|P-value:6.73E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.63|P-value:2.56E-6 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.24|P-value:7.27E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.35|P-value:4.92E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.76|P-value:1.38E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.72|P-value:1.23E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.67|P-value:1.55E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.85|P-value:7.44E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.84|P-value:7.83E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.39|P-value:4.21E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.24|P-value:7.00E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.48|P-value:3.05E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.52|P-value:2.68E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.54|P-value:2.49E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.67|P-value:1.51E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.33|P-value:5.25E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.63|P-value:1.79E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:6.49|P-value:8.41E-11 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.33|P-value:5.30E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.32|P-value:5.40E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.88|P-value:6.81E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.19|P-value:8.26E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.84|P-value:7.69E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.43|P-value:3.60E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.81|P-value:1.06E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.33|P-value:5.11E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.47|P-value:5.49E-6 ID:SGTC_1653|Compound:st012112|FD-Score:3.47|P-value:3.11E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.75|P-value:1.11E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.56|P-value:3.60E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.68|P-value:1.48E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.64|P-value:2.49E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.43|P-value:6.44E-6 ID:SGTC_2019|Compound:4016004|FD-Score:4.35|P-value:9.34E-6 ID:SGTC_2022|Compound:5136654|FD-Score:3.19|P-value:8.36E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.55|P-value:2.40E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.61|P-value:1.91E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-7.17|P-value:8.56E-13 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.79|P-value:9.62E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.83|P-value:4.85E-9 ID:SGTC_2601|Compound:securinine|FD-Score:4.11|P-value:2.61E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.39|P-value:4.16E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.96|P-value:4.96E-5 ID:SGTC_2715|Compound:st079500|FD-Score:-3.74|P-value:1.15E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.21|P-value:1.66E-5 ID:SGTC_2825|Compound:7998094|FD-Score:4.25|P-value:1.40E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.40|P-value:4.03E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.18|P-value:8.93E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.61|P-value:1.89E-4 ID:SGTC_3202|Compound:9113761|FD-Score:7.20|P-value:6.81E-13 ID:SGTC_3276|Compound:9139060|FD-Score:-3.25|P-value:6.97E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.26|P-value:6.73E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.63|P-value:2.56E-6 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.24|P-value:7.27E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.35|P-value:4.92E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.76|P-value:1.38E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.72|P-value:1.23E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.67|P-value:1.55E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.85|P-value:7.44E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.84|P-value:7.83E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.39|P-value:4.21E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.24|P-value:7.00E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.48|P-value:3.05E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.52|P-value:2.68E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.54|P-value:2.49E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.67|P-value:1.51E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.33|P-value:5.25E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.63|P-value:1.79E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:6.49|P-value:8.41E-11 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.33|P-value:5.30E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.32|P-value:5.40E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.88|P-value:6.81E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.19|P-value:8.26E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.84|P-value:7.69E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.43|P-value:3.60E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.81|P-value:1.06E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.33|P-value:5.11E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.47|P-value:5.49E-6 ID:SGTC_1653|Compound:st012112|FD-Score:3.47|P-value:3.11E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.75|P-value:1.11E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.56|P-value:3.60E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.68|P-value:1.48E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.64|P-value:2.49E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.43|P-value:6.44E-6 ID:SGTC_2019|Compound:4016004|FD-Score:4.35|P-value:9.34E-6 ID:SGTC_2022|Compound:5136654|FD-Score:3.19|P-value:8.36E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.55|P-value:2.40E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.61|P-value:1.91E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-7.17|P-value:8.56E-13 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.79|P-value:9.62E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.83|P-value:4.85E-9 ID:SGTC_2601|Compound:securinine|FD-Score:4.11|P-value:2.61E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.39|P-value:4.16E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.96|P-value:4.96E-5 ID:SGTC_2715|Compound:st079500|FD-Score:-3.74|P-value:1.15E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.21|P-value:1.66E-5 ID:SGTC_2825|Compound:7998094|FD-Score:4.25|P-value:1.40E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.40|P-value:4.03E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.18|P-value:8.93E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.61|P-value:1.89E-4 ID:SGTC_3202|Compound:9113761|FD-Score:7.20|P-value:6.81E-13 ID:SGTC_3276|Compound:9139060|FD-Score:-3.25|P-value:6.97E-4

Top fitness defect scores for YNL082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3202 9113761 7.20 49.5 µM 6.81E-13 4 3.03E-13
2 SGTC_1033 k072-0102 6.49 21.3 µM 8.41E-11 60S ribosome export 2 4.35E-11
3 SGTC_1565 sinapyl alcohol 4.81 95.1 µM 1.06E-6 10 7.38E-7
4 SGTC_271 rotenone 4.76 740.0 µM 1.38E-6 10 9.65E-7
5 SGTC_1922 5578187 4.64 25.0 µM 2.49E-6 TRP & mitochondrial translation 17 1.77E-6
6 SGTC_168 3970-0862 4.63 530.5 µM 2.56E-6 84 1.83E-6
7 SGTC_1869 3',7'-dimethoxyflavone 4.56 40.3 µM 3.60E-6 13 2.59E-6
8 SGTC_1625 st003711 4.47 30.1 µM 5.49E-6 calcium & mitochondrial duress 25 4.00E-6
9 SGTC_1923 st058458 4.43 19.1 µM 6.44E-6 22 4.72E-6
10 SGTC_2019 4016004 4.35 108.0 µM 9.34E-6 18 6.92E-6
11 SGTC_2825 7998094 4.25 58.4 µM 1.40E-5 fatty acid desaturase (OLE1) 24 1.05E-5
12 SGTC_2716 st080858 4.21 38.6 µM 1.66E-5 60S ribosome export 15 1.25E-5
13 SGTC_2601 securinine 4.11 100.0 µM 2.61E-5 27 2.00E-5
14 SGTC_340 k038-0059 3.85 454.0 µM 7.44E-5 ubiquinone biosynthesis & proteasome 48 5.87E-5
15 SGTC_1344 1488-0097 3.84 29.1 µM 7.69E-5 18 6.07E-5
16 SGTC_615 k087-0205 3.84 167.0 µM 7.83E-5 12 6.19E-5
17 SGTC_2564 betulinic acid 3.79 100.0 µM 9.62E-5 36 7.65E-5
18 SGTC_2160 5660466 3.75 132.9 µM 1.11E-4 60S ribosome export 24 8.87E-5
19 SGTC_440 fluspirilene 3.73 35.1 µM 1.18E-4 19 9.47E-5
20 SGTC_313 3474-0040 3.72 5.0 µM 1.23E-4 NEO1-PIK1 79 9.84E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.39E-19 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.108 3.28E-10 YBR072W HSP26 hom Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity
0.106 8.21E-10 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
0.102 3.54E-9 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.100 7.02E-9 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.100 7.72E-9 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.095 3.16E-8 YER148W SPT15 het TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
0.095 3.71E-8 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.094 4.40E-8 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.088 3.07E-7 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.087 4.36E-7 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.56E-6 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.082 1.78E-6 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.081 2.75E-6 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.079 4.30E-6 YOR043W WHI2 hom Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression