YNL083W / SAL1

ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL083W / SAL1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:5.13|P-value:7.45E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.01|P-value:1.93E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.00|P-value:2.08E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.48|P-value:1.78E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.24|P-value:7.02E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.70|P-value:8.62E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.75|P-value:6.01E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.31|P-value:4.87E-6 ID:SGTC_781|Compound:4335-2806|FD-Score:4.14|P-value:1.07E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.76|P-value:6.91E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.74|P-value:7.37E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.73|P-value:6.59E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.01|P-value:9.88E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:3.86E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.12|P-value:6.70E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.27|P-value:4.59E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.19|P-value:8.82E-6 ID:SGTC_1895|Compound:st058434|FD-Score:4.40|P-value:3.18E-6 ID:SGTC_1903|Compound:st060211|FD-Score:-6.93|P-value:8.78E-13 ID:SGTC_1956|Compound:st077085|FD-Score:3.80|P-value:4.77E-5 ID:SGTC_1957|Compound:st077035|FD-Score:4.32|P-value:4.71E-6 ID:SGTC_2124|Compound:5246320|FD-Score:3.13|P-value:6.46E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.29|P-value:4.29E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.69|P-value:8.90E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.20|P-value:5.12E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.73|P-value:6.16E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-4.30|P-value:6.46E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.18|P-value:5.53E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.28|P-value:3.85E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.19|P-value:8.69E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:5.13|P-value:7.45E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.01|P-value:1.93E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.00|P-value:2.08E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.48|P-value:1.78E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.24|P-value:7.02E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.70|P-value:8.62E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.75|P-value:6.01E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.31|P-value:4.87E-6 ID:SGTC_781|Compound:4335-2806|FD-Score:4.14|P-value:1.07E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.76|P-value:6.91E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.74|P-value:7.37E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.73|P-value:6.59E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.01|P-value:9.88E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:3.86E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.12|P-value:6.70E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.27|P-value:4.59E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.19|P-value:8.82E-6 ID:SGTC_1895|Compound:st058434|FD-Score:4.40|P-value:3.18E-6 ID:SGTC_1903|Compound:st060211|FD-Score:-6.93|P-value:8.78E-13 ID:SGTC_1956|Compound:st077085|FD-Score:3.80|P-value:4.77E-5 ID:SGTC_1957|Compound:st077035|FD-Score:4.32|P-value:4.71E-6 ID:SGTC_2124|Compound:5246320|FD-Score:3.13|P-value:6.46E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.29|P-value:4.29E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.69|P-value:8.90E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.20|P-value:5.12E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.73|P-value:6.16E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-4.30|P-value:6.46E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.18|P-value:5.53E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.28|P-value:3.85E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.19|P-value:8.69E-6

Top fitness defect scores for YNL083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 5.13 471.9 µM 7.45E-8 ubiquinone biosynthesis & proteasome 110 1.46E-7
2 SGTC_2799 7812892 4.73 81.8 µM 6.16E-7 superoxide 19 1.11E-6
3 SGTC_1895 st058434 4.40 18.3 µM 3.18E-6 12 5.32E-6
4 SGTC_1957 st077035 4.32 62.4 µM 4.71E-6 10 7.76E-6
5 SGTC_686 1319-0111 4.31 510.0 µM 4.87E-6 60S ribosome export 21 8.02E-6
6 SGTC_493 zm226600 4.24 134.0 µM 7.02E-6 mitochondrial processes 12 1.14E-5
7 SGTC_3331 9141060 4.19 2.0 µM 8.69E-6 cell wall 28 1.40E-5
8 SGTC_1891 st059073 4.19 26.2 µM 8.82E-6 TSC3-RPN4 18 1.42E-5
9 SGTC_781 4335-2806 4.14 94.4 µM 1.07E-5 14 1.70E-5
10 SGTC_142 0335-0849 4.01 62.7 µM 1.93E-5 ubiquinone biosynthesis & proteasome 123 3.00E-5
11 SGTC_158 k038-0087 4.00 26.4 µM 2.08E-5 ubiquinone biosynthesis & proteasome 133 3.22E-5
12 SGTC_1956 st077085 3.80 54.0 µM 4.77E-5 22 7.14E-5
13 SGTC_600 1495-0418 3.75 41.6 µM 6.01E-5 RPP1 & pyrimidine depletion 15 8.90E-5
14 SGTC_1454 4239-0054 3.73 42.6 µM 6.59E-5 42 9.73E-5
15 SGTC_2596 sinensetin 3.60 100.0 µM 1.10E-4 45 1.59E-4
16 SGTC_479 n-linoleoylglycine 3.48 10.0 µM 1.78E-4 19 2.52E-4
17 SGTC_1329 1447-1697 3.43 50.6 µM 2.11E-4 28 2.97E-4
18 SGTC_3320 9137005 3.28 35.1 µM 3.85E-4 endomembrane recycling 32 5.27E-4
19 SGTC_2615 purpurogallin-4-carboxylic acid 3.20 100.0 µM 5.12E-4 redox potentiating 104 6.93E-4
20 SGTC_2962 9082311 3.18 13.2 µM 5.53E-4 55 7.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 5.39E-31 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.182 1.93E-26 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.178 2.88E-25 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.173 4.80E-24 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.169 8.33E-23 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.168 1.65E-22 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.167 2.31E-22 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.167 2.72E-22 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.158 4.31E-20 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.155 1.57E-19 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.154 3.62E-19 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.150 2.35E-18 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.148 5.59E-18 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.147 1.20E-17 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.144 5.29E-17 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)