YNL084C / END3

EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL084C / END3

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.89|P-value:4.42E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.56|P-value:4.86E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.93|P-value:1.96E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.74|P-value:7.02E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.24|P-value:3.74E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.15|P-value:4.92E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:3.75|P-value:6.81E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.46|P-value:6.71E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:6.05|P-value:1.13E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:5.08|P-value:7.15E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:5.00|P-value:9.57E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.92|P-value:6.25E-12 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.25|P-value:2.84E-10 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.83|P-value:5.37E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:14.30|P-value:1.19E-34 ID:SGTC_422|Compound:cantharidin|FD-Score:5.92|P-value:2.09E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:5.14|P-value:5.47E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:4.27|P-value:1.33E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:6.13|P-value:8.03E-8 ID:SGTC_459|Compound:nigericin|FD-Score:5.18|P-value:4.69E-6 ID:SGTC_469|Compound:w7|FD-Score:4.12|P-value:2.15E-4 ID:SGTC_500|Compound:h-89|FD-Score:7.44|P-value:1.01E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.67|P-value:8.22E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.90|P-value:4.33E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.32|P-value:2.72E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:11.40|P-value:1.03E-22 ID:SGTC_788|Compound:1182-0090|FD-Score:5.62|P-value:7.88E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:5.33|P-value:2.59E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:4.41|P-value:8.13E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.94|P-value:1.20E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:5.42|P-value:1.79E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.90|P-value:1.43E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.51|P-value:5.81E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.78|P-value:6.23E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.58|P-value:4.56E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.86|P-value:4.88E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.08|P-value:7.16E-6 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.79|P-value:3.75E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.03|P-value:2.79E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.13|P-value:2.06E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.54|P-value:5.16E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.72|P-value:7.51E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.73|P-value:7.25E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.11|P-value:2.22E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:16.90|P-value:1.04E-47 ID:SGTC_1635|Compound:st007035|FD-Score:7.51|P-value:6.70E-11 ID:SGTC_1656|Compound:st012921|FD-Score:5.41|P-value:1.85E-6 ID:SGTC_1750|Compound:st081859|FD-Score:6.88|P-value:2.01E-9 ID:SGTC_1773|Compound:st048542|FD-Score:4.42|P-value:7.97E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.61|P-value:4.01E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.30|P-value:2.18E-10 ID:SGTC_1876|Compound:myriocin|FD-Score:4.71|P-value:2.81E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.65|P-value:8.73E-4 ID:SGTC_2007|Compound:4011539|FD-Score:12.10|P-value:2.33E-25 ID:SGTC_2009|Compound:4012297|FD-Score:8.08|P-value:2.38E-12 ID:SGTC_2011|Compound:4012611|FD-Score:-4.06|P-value:2.52E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.94|P-value:3.82E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.52|P-value:5.67E-5 ID:SGTC_2179|Compound:6298986|FD-Score:6.24|P-value:4.87E-8 ID:SGTC_2183|Compound:6420625|FD-Score:4.00|P-value:3.15E-4 ID:SGTC_2272|Compound:7805186|FD-Score:7.75|P-value:1.68E-11 ID:SGTC_2286|Compound:7945697|FD-Score:3.66|P-value:8.86E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.95|P-value:3.59E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.65|P-value:9.01E-4 ID:SGTC_2399|Compound:5884133|FD-Score:16.30|P-value:1.97E-44 ID:SGTC_2450|Compound:5739737|FD-Score:4.47|P-value:6.77E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.82|P-value:1.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.84|P-value:1.95E-17 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.13|P-value:5.86E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.67|P-value:8.45E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.65|P-value:8.82E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:7.21|P-value:3.61E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:14.50|P-value:1.91E-35 ID:SGTC_2699|Compound:st077704|FD-Score:4.45|P-value:7.25E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:15.10|P-value:2.62E-38 ID:SGTC_2806|Compound:7952793|FD-Score:3.69|P-value:8.11E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.97|P-value:3.46E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.47|P-value:6.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.31|P-value:2.72E-6 ID:SGTC_2932|Compound:9016711|FD-Score:5.38|P-value:2.14E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-3.65|P-value:8.71E-4 ID:SGTC_2935|Compound:9038016|FD-Score:9.83|P-value:2.05E-17 ID:SGTC_2968|Compound:9090663|FD-Score:-6.07|P-value:9.94E-8 ID:SGTC_2973|Compound:9094665|FD-Score:4.13|P-value:2.07E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.75|P-value:6.52E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.65|P-value:3.49E-5 ID:SGTC_3170|Compound:9103054|FD-Score:4.75|P-value:2.47E-5 ID:SGTC_3304|Compound:9125678|FD-Score:5.53|P-value:1.12E-6 ID:SGTC_3329|Compound:9141233|FD-Score:4.62|P-value:3.99E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.89|P-value:4.42E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.56|P-value:4.86E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.93|P-value:1.96E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.74|P-value:7.02E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.24|P-value:3.74E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.15|P-value:4.92E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:3.75|P-value:6.81E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.46|P-value:6.71E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:6.05|P-value:1.13E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:5.08|P-value:7.15E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:5.00|P-value:9.57E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.92|P-value:6.25E-12 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.25|P-value:2.84E-10 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.83|P-value:5.37E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:14.30|P-value:1.19E-34 ID:SGTC_422|Compound:cantharidin|FD-Score:5.92|P-value:2.09E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:5.14|P-value:5.47E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:4.27|P-value:1.33E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:6.13|P-value:8.03E-8 ID:SGTC_459|Compound:nigericin|FD-Score:5.18|P-value:4.69E-6 ID:SGTC_469|Compound:w7|FD-Score:4.12|P-value:2.15E-4 ID:SGTC_500|Compound:h-89|FD-Score:7.44|P-value:1.01E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.67|P-value:8.22E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.90|P-value:4.33E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.32|P-value:2.72E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:11.40|P-value:1.03E-22 ID:SGTC_788|Compound:1182-0090|FD-Score:5.62|P-value:7.88E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:5.33|P-value:2.59E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:4.41|P-value:8.13E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.94|P-value:1.20E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:5.42|P-value:1.79E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.90|P-value:1.43E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.51|P-value:5.81E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.78|P-value:6.23E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.58|P-value:4.56E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.86|P-value:4.88E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.08|P-value:7.16E-6 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.79|P-value:3.75E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.03|P-value:2.79E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.13|P-value:2.06E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.54|P-value:5.16E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.72|P-value:7.51E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.73|P-value:7.25E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.11|P-value:2.22E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:16.90|P-value:1.04E-47 ID:SGTC_1635|Compound:st007035|FD-Score:7.51|P-value:6.70E-11 ID:SGTC_1656|Compound:st012921|FD-Score:5.41|P-value:1.85E-6 ID:SGTC_1750|Compound:st081859|FD-Score:6.88|P-value:2.01E-9 ID:SGTC_1773|Compound:st048542|FD-Score:4.42|P-value:7.97E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.61|P-value:4.01E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.30|P-value:2.18E-10 ID:SGTC_1876|Compound:myriocin|FD-Score:4.71|P-value:2.81E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.65|P-value:8.73E-4 ID:SGTC_2007|Compound:4011539|FD-Score:12.10|P-value:2.33E-25 ID:SGTC_2009|Compound:4012297|FD-Score:8.08|P-value:2.38E-12 ID:SGTC_2011|Compound:4012611|FD-Score:-4.06|P-value:2.52E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.94|P-value:3.82E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.52|P-value:5.67E-5 ID:SGTC_2179|Compound:6298986|FD-Score:6.24|P-value:4.87E-8 ID:SGTC_2183|Compound:6420625|FD-Score:4.00|P-value:3.15E-4 ID:SGTC_2272|Compound:7805186|FD-Score:7.75|P-value:1.68E-11 ID:SGTC_2286|Compound:7945697|FD-Score:3.66|P-value:8.86E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.95|P-value:3.59E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.65|P-value:9.01E-4 ID:SGTC_2399|Compound:5884133|FD-Score:16.30|P-value:1.97E-44 ID:SGTC_2450|Compound:5739737|FD-Score:4.47|P-value:6.77E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.82|P-value:1.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.84|P-value:1.95E-17 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.13|P-value:5.86E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.67|P-value:8.45E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.65|P-value:8.82E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:7.21|P-value:3.61E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:14.50|P-value:1.91E-35 ID:SGTC_2699|Compound:st077704|FD-Score:4.45|P-value:7.25E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:15.10|P-value:2.62E-38 ID:SGTC_2806|Compound:7952793|FD-Score:3.69|P-value:8.11E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.97|P-value:3.46E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.47|P-value:6.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.31|P-value:2.72E-6 ID:SGTC_2932|Compound:9016711|FD-Score:5.38|P-value:2.14E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-3.65|P-value:8.71E-4 ID:SGTC_2935|Compound:9038016|FD-Score:9.83|P-value:2.05E-17 ID:SGTC_2968|Compound:9090663|FD-Score:-6.07|P-value:9.94E-8 ID:SGTC_2973|Compound:9094665|FD-Score:4.13|P-value:2.07E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.75|P-value:6.52E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.65|P-value:3.49E-5 ID:SGTC_3170|Compound:9103054|FD-Score:4.75|P-value:2.47E-5 ID:SGTC_3304|Compound:9125678|FD-Score:5.53|P-value:1.12E-6 ID:SGTC_3329|Compound:9141233|FD-Score:4.62|P-value:3.99E-5

Top fitness defect scores for YNL084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1597 7-benzyloxygramine 16.90 47.5 µM 1.04E-47 calcium & mitochondrial duress 6 2.03E-64
2 SGTC_2399 5884133 16.30 200.0 µM 1.97E-44 cell wall signaling 3 6.02E-60
3 SGTC_2741 miltefosine 15.10 3.0 µM 2.62E-38 2 1.35E-51
4 SGTC_2679 rapamycin 14.50 1.0 nM 1.91E-35 7 1.09E-47
5 SGTC_310 1273-0058 14.30 1.1 µM 1.19E-34 mitochondrial stress 10 1.31E-46
6 SGTC_2007 4011539 12.10 71.8 µM 2.33E-25 cell wall signaling 9 6.11E-34
7 SGTC_663 1486-0733 11.40 13.9 µM 1.03E-22 cell wall signaling 10 2.46E-30
8 SGTC_2582 agaric acid 9.84 100.0 µM 1.95E-17 redox potentiating 66 3.80E-23
9 SGTC_2935 9038016 9.83 30.0 µM 2.05E-17 1 4.07E-23
10 SGTC_2009 4012297 8.08 12.1 µM 2.38E-12 cell wall signaling 14 3.16E-16
11 SGTC_221 trifluoperazine 7.92 10.3 µM 6.25E-12 NEO1-PIK1 86 1.17E-15
12 SGTC_2272 7805186 7.75 180.0 µM 1.68E-11 cell wall signaling 4 4.50E-15
13 SGTC_1635 st007035 7.51 42.4 µM 6.70E-11 103 2.94E-14
14 SGTC_500 h-89 7.44 112.0 µM 1.01E-10 cell wall signaling 6 5.17E-14
15 SGTC_1844 rapamycin 7.30 4.0 nM 2.18E-10 67 1.46E-13
16 SGTC_241 5hr heat shock (37°C) + cantharidin 7.25 155.4 µM 2.84E-10 cell wall signaling 23 2.10E-13
17 SGTC_2666 tannic acid 7.21 100.0 µM 3.61E-10 iron homeostasis 6 2.89E-13
18 SGTC_168 3970-0862 7.15 530.5 µM 4.92E-10 26 4.42E-13
19 SGTC_1750 st081859 6.88 2.4 µM 2.01E-9 endomembrane recycling 90 2.99E-12
20 SGTC_2179 6298986 6.24 200.0 µM 4.87E-8 heme requiring 3 2.25E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.306 1.64E-73 YBL007C SLA1 hom Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
0.305 2.02E-73 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.282 1.38E-62 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.281 9.92E-62 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.269 1.60E-56 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.266 1.73E-55 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.263 2.34E-54 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.250 3.79E-49 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.247 9.74E-48 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.236 1.10E-43 YOR035C SHE4 hom Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
0.219 9.82E-38 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.207 1.16E-33 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.204 9.25E-33 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.196 1.89E-30 YOR008C SLG1 hom Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.192 5.31E-29 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding