YNL085W / MKT1

Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL085W / MKT1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:-3.10|P-value:6.93E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.92|P-value:5.60E-10 ID:SGTC_147|Compound:4466-0538|FD-Score:3.22|P-value:4.73E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.04|P-value:8.82E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.10|P-value:7.26E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:7.90|P-value:2.11E-16 ID:SGTC_610|Compound:4215-0184|FD-Score:3.17|P-value:5.60E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.83|P-value:3.91E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-4.01|P-value:1.77E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.05|P-value:8.48E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.02|P-value:9.49E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.51|P-value:1.55E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.28|P-value:3.69E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.06|P-value:8.42E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:7.16|P-value:8.47E-14 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.83|P-value:4.06E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.42|P-value:2.12E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.16|P-value:8.81E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.00|P-value:9.77E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.32|P-value:3.00E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.29|P-value:5.10E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.46|P-value:1.88E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.80|P-value:4.39E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.28|P-value:3.79E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.54|P-value:1.35E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.64|P-value:9.17E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.04|P-value:8.97E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.32|P-value:3.04E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.29|P-value:3.63E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.15|P-value:6.07E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.65|P-value:8.82E-7 ID:SGTC_2366|Compound:9070441|FD-Score:3.59|P-value:1.12E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.56|P-value:1.21E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.23|P-value:4.42E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.81|P-value:4.23E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.40|P-value:2.34E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.25|P-value:4.24E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.27|P-value:3.85E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.50|P-value:1.61E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.18|P-value:5.46E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.06|P-value:7.96E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.32|P-value:3.16E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.48|P-value:1.70E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.39|P-value:2.36E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.36|P-value:2.66E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.48|P-value:2.07E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-3.81|P-value:4.31E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.26|P-value:3.96E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.69|P-value:7.49E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.22|P-value:4.64E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.25|P-value:4.24E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.10|P-value:6.93E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.92|P-value:5.60E-10 ID:SGTC_147|Compound:4466-0538|FD-Score:3.22|P-value:4.73E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.04|P-value:8.82E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.10|P-value:7.26E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:7.90|P-value:2.11E-16 ID:SGTC_610|Compound:4215-0184|FD-Score:3.17|P-value:5.60E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.83|P-value:3.91E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-4.01|P-value:1.77E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.05|P-value:8.48E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.02|P-value:9.49E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.51|P-value:1.55E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.28|P-value:3.69E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.06|P-value:8.42E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:7.16|P-value:8.47E-14 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.83|P-value:4.06E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.42|P-value:2.12E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.16|P-value:8.81E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.00|P-value:9.77E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.32|P-value:3.00E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.29|P-value:5.10E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.46|P-value:1.88E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.80|P-value:4.39E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.28|P-value:3.79E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.54|P-value:1.35E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.64|P-value:9.17E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.04|P-value:8.97E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.32|P-value:3.04E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.29|P-value:3.63E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.15|P-value:6.07E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.65|P-value:8.82E-7 ID:SGTC_2366|Compound:9070441|FD-Score:3.59|P-value:1.12E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.56|P-value:1.21E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.23|P-value:4.42E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.81|P-value:4.23E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.40|P-value:2.34E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.25|P-value:4.24E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.27|P-value:3.85E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.50|P-value:1.61E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.18|P-value:5.46E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.06|P-value:7.96E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.32|P-value:3.16E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.48|P-value:1.70E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.39|P-value:2.36E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.36|P-value:2.66E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.48|P-value:2.07E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-3.81|P-value:4.31E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.26|P-value:3.96E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.69|P-value:7.49E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.22|P-value:4.64E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.25|P-value:4.24E-4

Top fitness defect scores for YNL085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_551 k048-0028 7.90 34.9 µM 2.11E-16 1 1.38E-15
2 SGTC_1076 itraconazole 7.16 331.0 nM 8.47E-14 6 3.96E-13
3 SGTC_131 0141-0277 5.92 33.9 µM 5.60E-10 7 1.61E-9
4 SGTC_2135 5326629 4.65 150.4 µM 8.82E-7 RPP1 & pyrimidine depletion 11 1.69E-6
5 SGTC_2991 9074669 4.48 71.4 µM 2.07E-6 azole & statin 46 3.80E-6
6 SGTC_1505 k297-0037 4.29 20.6 µM 5.10E-6 13 8.90E-6
7 SGTC_1214 0358-0031 4.14 63.7 µM 1.06E-5 11 1.77E-5
8 SGTC_1128 3448-9350 3.83 235.0 µM 4.06E-5 26 6.35E-5
9 SGTC_3101 9120531 3.69 49.5 µM 7.49E-5 41 1.13E-4
10 SGTC_1779 st039427 3.64 55.0 µM 9.17E-5 36 1.37E-4
11 SGTC_1998 st075797 3.61 76.8 µM 1.02E-4 mitochondrial response to ROS 24 1.52E-4
12 SGTC_2366 9070441 3.59 60.6 µM 1.12E-4 41 1.66E-4
13 SGTC_1698 5-fluorocytosine 3.54 1.1 µM 1.35E-4 exosome 14 1.99E-4
14 SGTC_816 0325-0417 3.51 81.3 µM 1.51E-4 19 2.20E-4
15 SGTC_925 2064-1272 3.51 59.6 µM 1.55E-4 36 2.26E-4
16 SGTC_2536 dehydroabietamide 3.50 32.0 µM 1.61E-4 53 2.33E-4
17 SGTC_2874 9043904 3.48 71.4 µM 1.70E-4 25 2.46E-4
18 SGTC_1519 esterone 3.46 74.0 µM 1.88E-4 DNA intercalators 34 2.70E-4
19 SGTC_924 2046-0044 3.44 21.3 µM 2.05E-4 24 2.94E-4
20 SGTC_2412 st077135 3.40 33.4 µM 2.34E-4 44 3.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.04E-10 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.104 1.45E-9 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.094 5.15E-8 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.086 5.34E-7 YCR021C HSP30 hom Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
0.085 8.02E-7 YGR079W_p YGR079W_p hom Putative protein of unknown function; YGR079W is not an essential gene
0.085 8.03E-7 YER088C DOT6 hom Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.11E-6 YNR004W_p SWM2_p hom Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
0.080 3.45E-6 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.079 4.45E-6 YDR091C RLI1 het Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species
0.078 5.39E-6 YBL073W_d YBL073W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C
0.077 7.55E-6 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.076 9.24E-6 YBR004C GPI18 het Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
0.072 2.76E-5 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.072 3.02E-5 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.072 3.10E-5 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication