YNL089C_d

Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL089C / YNL089C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.48|P-value:1.81E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.86|P-value:3.67E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.13|P-value:5.42E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.37|P-value:3.54E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:5.52|P-value:6.58E-9 ID:SGTC_533|Compound:1222-0222|FD-Score:3.77|P-value:5.47E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.64|P-value:9.23E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:3.84|P-value:4.08E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:7.93|P-value:1.51E-16 ID:SGTC_684|Compound:1140-0066|FD-Score:5.37|P-value:1.63E-8 ID:SGTC_702|Compound:1488-0190|FD-Score:4.24|P-value:6.48E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.07|P-value:8.22E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.08|P-value:8.11E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.05|P-value:8.88E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.14|P-value:6.45E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.75|P-value:5.82E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.47|P-value:1.42E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:7.20|P-value:6.07E-14 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.61|P-value:1.07E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-6.25|P-value:3.88E-11 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.61|P-value:1.08E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.05|P-value:7.15E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.40|P-value:2.42E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.17|P-value:5.90E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.02|P-value:9.91E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.09|P-value:6.12E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.11|P-value:7.34E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.18|P-value:4.41E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.27|P-value:3.96E-4 ID:SGTC_2078|Compound:5212016|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.17|P-value:4.58E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-2.95|P-value:9.99E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.49|P-value:1.70E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.39|P-value:2.53E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.16|P-value:5.99E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.44|P-value:2.08E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.20|P-value:5.19E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.22|P-value:3.85E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.61|P-value:1.06E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.84|P-value:4.02E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.15|P-value:6.15E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.01|P-value:8.31E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.83|P-value:3.26E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.19|P-value:6.17E-6 ID:SGTC_3189|Compound:9110682|FD-Score:-3.60|P-value:8.41E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.54|P-value:1.08E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.08|P-value:7.92E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.30|P-value:3.59E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.14|P-value:5.21E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.27|P-value:5.72E-6 ID:SGTC_3345|Compound:9148410|FD-Score:4.21|P-value:7.68E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.48|P-value:1.81E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.86|P-value:3.67E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.13|P-value:5.42E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.37|P-value:3.54E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:5.52|P-value:6.58E-9 ID:SGTC_533|Compound:1222-0222|FD-Score:3.77|P-value:5.47E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.64|P-value:9.23E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:3.84|P-value:4.08E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:7.93|P-value:1.51E-16 ID:SGTC_684|Compound:1140-0066|FD-Score:5.37|P-value:1.63E-8 ID:SGTC_702|Compound:1488-0190|FD-Score:4.24|P-value:6.48E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.07|P-value:8.22E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.08|P-value:8.11E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.05|P-value:8.88E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.14|P-value:6.45E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.75|P-value:5.82E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.47|P-value:1.42E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:7.20|P-value:6.07E-14 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.61|P-value:1.07E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-6.25|P-value:3.88E-11 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.61|P-value:1.08E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.05|P-value:7.15E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.40|P-value:2.42E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.17|P-value:5.90E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.02|P-value:9.91E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.09|P-value:6.12E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.11|P-value:7.34E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.18|P-value:4.41E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.27|P-value:3.96E-4 ID:SGTC_2078|Compound:5212016|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.17|P-value:4.58E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-2.95|P-value:9.99E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.49|P-value:1.70E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.39|P-value:2.53E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.16|P-value:5.99E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.44|P-value:2.08E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.20|P-value:5.19E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.22|P-value:3.85E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.61|P-value:1.06E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.84|P-value:4.02E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.15|P-value:6.15E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.01|P-value:8.31E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.83|P-value:3.26E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.19|P-value:6.17E-6 ID:SGTC_3189|Compound:9110682|FD-Score:-3.60|P-value:8.41E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.54|P-value:1.08E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.08|P-value:7.92E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.30|P-value:3.59E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.14|P-value:5.21E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.27|P-value:5.72E-6 ID:SGTC_3345|Compound:9148410|FD-Score:4.21|P-value:7.68E-6

Top fitness defect scores for YNL089C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_663 1486-0733 7.93 13.9 µM 1.51E-16 cell wall signaling 16 1.11E-15
2 SGTC_1448 4255-0083 7.20 152.0 µM 6.07E-14 ERG2 2 3.09E-13
3 SGTC_367 0335-0881 5.52 7.1 µM 6.58E-9 ubiquinone biosynthesis & proteasome 30 1.66E-8
4 SGTC_684 1140-0066 5.37 328.0 µM 1.63E-8 Golgi 5 3.91E-8
5 SGTC_360 0957-0399 4.37 1.0 µM 3.54E-6 cell wall 33 6.19E-6
6 SGTC_3337 9144342 4.27 33.5 µM 5.72E-6 21 9.71E-6
7 SGTC_702 1488-0190 4.24 94.0 µM 6.48E-6 amide catabolism 11 1.09E-5
8 SGTC_3345 9148410 4.21 3.6 µM 7.68E-6 5 1.28E-5
9 SGTC_228 caffeine 3.86 993.1 µM 3.67E-5 10 5.61E-5
10 SGTC_2958 9077254 3.84 16.7 µM 4.02E-5 35 6.11E-5
11 SGTC_661 1304-0007 3.84 33.6 µM 4.08E-5 25 6.20E-5
12 SGTC_533 1222-0222 3.77 6.7 µM 5.47E-5 PDR1 36 8.18E-5
13 SGTC_1405 3909-7894 3.75 12.0 µM 5.82E-5 60S ribosome export 14 8.67E-5
14 SGTC_549 1661-1316 3.64 519.0 µM 9.23E-5 24 1.34E-4
15 SGTC_2954 9074818 3.61 52.7 µM 1.06E-4 46 1.53E-4
16 SGTC_1452 4194-0072 3.61 190.0 µM 1.07E-4 21 1.54E-4
17 SGTC_1469 k284-2957 3.61 126.0 µM 1.08E-4 14 1.56E-4
18 SGTC_2078 5212016 3.60 200.0 µM 1.09E-4 60S ribosome export 23 1.56E-4
19 SGTC_2749 bexarotene 3.54 57.4 µM 1.40E-4 38 1.98E-4
20 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.49 15.3 µM 1.70E-4 53 2.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.42E-30 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.176 1.00E-24 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.167 2.67E-22 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.166 3.80E-22 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.165 6.27E-22 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.160 1.11E-20 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.160 1.95E-20 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.135 4.31E-15 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.127 1.69E-13 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.123 7.91E-13 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.116 1.62E-11 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.107 4.61E-10 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.107 5.04E-10 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.106 7.06E-10 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.106 7.55E-10 YBR142W MAK5 het Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits