YNL090W / RHO2

Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL090W / RHO2

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.10|P-value:9.20E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:6.14|P-value:4.94E-10 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.61|P-value:1.49E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.55|P-value:2.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.56|P-value:2.93E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.44|P-value:3.20E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.70|P-value:1.44E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.30|P-value:9.59E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.12|P-value:9.86E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.22|P-value:6.95E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.77|P-value:9.01E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.16|P-value:8.45E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.18|P-value:7.22E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.31|P-value:7.82E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:5.21|P-value:1.11E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:8.43|P-value:2.30E-17 ID:SGTC_935|Compound:2996-0153|FD-Score:3.29|P-value:5.42E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.34|P-value:4.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.70|P-value:1.17E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-5.46|P-value:2.35E-8 ID:SGTC_1058|Compound:3448-5425|FD-Score:-6.29|P-value:1.52E-10 ID:SGTC_1205|Compound:4161-2785|FD-Score:12.40|P-value:2.25E-35 ID:SGTC_1523|Compound:st012844|FD-Score:4.57|P-value:2.73E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.81|P-value:7.66E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.28|P-value:5.56E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.13|P-value:9.45E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.44|P-value:3.14E-4 ID:SGTC_1771|Compound:st048882|FD-Score:5.30|P-value:6.80E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.63|P-value:1.02E-8 ID:SGTC_1812|Compound:st052057|FD-Score:-3.63|P-value:1.39E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.27|P-value:5.78E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.31|P-value:9.16E-6 ID:SGTC_2052|Compound:5265182|FD-Score:5.86|P-value:2.79E-9 ID:SGTC_2108|Compound:5365811|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.75|P-value:9.76E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.52|P-value:2.33E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.53|P-value:3.33E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.96|P-value:4.18E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.36|P-value:4.18E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.55|P-value:1.62E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.96|P-value:4.09E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.20|P-value:1.30E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.67|P-value:1.48E-6 ID:SGTC_2824|Compound:7998404|FD-Score:-4.07|P-value:2.26E-5 ID:SGTC_2940|Compound:9060638|FD-Score:4.55|P-value:3.09E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.65|P-value:1.45E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.10|P-value:9.20E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:6.14|P-value:4.94E-10 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.61|P-value:1.49E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.55|P-value:2.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.56|P-value:2.93E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.44|P-value:3.20E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.70|P-value:1.44E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.30|P-value:9.59E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.12|P-value:9.86E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.22|P-value:6.95E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.77|P-value:9.01E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.16|P-value:8.45E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.18|P-value:7.22E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.31|P-value:7.82E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:5.21|P-value:1.11E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:8.43|P-value:2.30E-17 ID:SGTC_935|Compound:2996-0153|FD-Score:3.29|P-value:5.42E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.34|P-value:4.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.70|P-value:1.17E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-5.46|P-value:2.35E-8 ID:SGTC_1058|Compound:3448-5425|FD-Score:-6.29|P-value:1.52E-10 ID:SGTC_1205|Compound:4161-2785|FD-Score:12.40|P-value:2.25E-35 ID:SGTC_1523|Compound:st012844|FD-Score:4.57|P-value:2.73E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.81|P-value:7.66E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.28|P-value:5.56E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.13|P-value:9.45E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.44|P-value:3.14E-4 ID:SGTC_1771|Compound:st048882|FD-Score:5.30|P-value:6.80E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.63|P-value:1.02E-8 ID:SGTC_1812|Compound:st052057|FD-Score:-3.63|P-value:1.39E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.27|P-value:5.78E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.31|P-value:9.16E-6 ID:SGTC_2052|Compound:5265182|FD-Score:5.86|P-value:2.79E-9 ID:SGTC_2108|Compound:5365811|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.75|P-value:9.76E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.52|P-value:2.33E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.53|P-value:3.33E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.96|P-value:4.18E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.36|P-value:4.18E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.55|P-value:1.62E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.96|P-value:4.09E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.20|P-value:1.30E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.67|P-value:1.48E-6 ID:SGTC_2824|Compound:7998404|FD-Score:-4.07|P-value:2.26E-5 ID:SGTC_2940|Compound:9060638|FD-Score:4.55|P-value:3.09E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.65|P-value:1.45E-4

Top fitness defect scores for YNL090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1205 4161-2785 12.40 76.0 µM 2.25E-35 2 1.37E-35
2 SGTC_920 mycophenolic acid 8.43 780.4 nM 2.30E-17 1 1.74E-17
3 SGTC_23 0213-0011 6.14 40.0 µM 4.94E-10 copper-dependent oxidative stress 9 4.14E-10
4 SGTC_2052 5265182 5.86 7.1 µM 2.79E-9 4 2.37E-9
5 SGTC_1785 bathophenanthroline 5.63 24.0 µM 1.02E-8 heme requiring 13 8.76E-9
6 SGTC_2289 7946404 5.55 165.1 µM 1.62E-8 44 1.39E-8
7 SGTC_1771 st048882 5.30 4.2 µM 6.80E-8 RPP1 & pyrimidine depletion 5 5.89E-8
8 SGTC_912 3474-0017 5.21 2.2 µM 1.11E-7 9 9.66E-8
9 SGTC_383 2324-0395 4.70 7.4 µM 1.44E-6 azole & statin 22 1.28E-6
10 SGTC_1523 st012844 4.57 44.7 µM 2.73E-6 60S ribosome export 7 2.43E-6
11 SGTC_138 0850-0259 4.56 40.9 µM 2.93E-6 cell wall 162 2.60E-6
12 SGTC_2940 9060638 4.55 45.9 µM 3.09E-6 amide catabolism 10 2.74E-6
13 SGTC_2283 7944793 4.53 200.0 µM 3.33E-6 25 2.96E-6
14 SGTC_2024 5144227 4.31 134.0 µM 9.16E-6 27 8.20E-6
15 SGTC_387 norethindrone acetate 4.30 66.7 µM 9.59E-6 6 8.58E-6
16 SGTC_2541 muurolladie-3-one 3.96 83.1 µM 4.09E-5 excess fatty acid 26 3.70E-5
17 SGTC_2286 7945697 3.96 125.0 µM 4.18E-5 56 3.78E-5
18 SGTC_1531 st059297 3.81 52.4 µM 7.66E-5 19 6.97E-5
19 SGTC_726 3448-4391 3.77 34.2 µM 9.01E-5 16 8.20E-5
20 SGTC_2248 tofa 3.75 1.1 µM 9.76E-5 sphingolipid biosynthesis & PDR1 42 8.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.07E-17 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.128 8.57E-14 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.124 5.20E-13 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.111 1.01E-10 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.109 2.11E-10 YPR134W MSS18 hom Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
0.108 3.44E-10 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.108 3.81E-10 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.105 1.13E-9 YOR341W RPA190 het RNA polymerase I largest subunit A190
0.104 1.67E-9 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.102 3.22E-9 YMR294W JNM1 hom Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
0.100 6.34E-9 YHR074W QNS1 het Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
0.098 1.12E-8 YKL047W_p ANR2_p hom Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.097 1.80E-8 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.094 5.49E-8 YCL061C MRC1 hom S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres
0.092 9.69E-8 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress