YNL091W / NST1

Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL091W / NST1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.40|P-value:2.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.95|P-value:2.93E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:4.26|P-value:8.32E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.57|P-value:1.58E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.42|P-value:2.73E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.53|P-value:1.81E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.76|P-value:7.20E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.29|P-value:4.59E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.07|P-value:2.02E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.36|P-value:5.27E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.12|P-value:8.35E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.15|P-value:7.38E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.35|P-value:3.55E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.27|P-value:4.77E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.21|P-value:1.07E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:3.25|P-value:5.15E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.26|P-value:5.01E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.69|P-value:9.74E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.25|P-value:5.06E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.58|P-value:1.84E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.17|P-value:1.28E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.64|P-value:1.20E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.81|P-value:6.00E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.09|P-value:9.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.84|P-value:5.37E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.49|P-value:2.95E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.53|P-value:2.34E-6 ID:SGTC_1778|Compound:st046819|FD-Score:3.44|P-value:2.53E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.54|P-value:1.77E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.10|P-value:8.93E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-4.78|P-value:7.00E-7 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.23|P-value:5.68E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_2165|Compound:5727197|FD-Score:5.49|P-value:1.50E-8 ID:SGTC_2192|Compound:5915882|FD-Score:4.17|P-value:1.25E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.20|P-value:6.25E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.16|P-value:7.11E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.86|P-value:4.72E-7 ID:SGTC_2270|Compound:7924575|FD-Score:-3.26|P-value:5.10E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.27|P-value:4.73E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.61|P-value:1.59E-6 ID:SGTC_2342|Compound:7990637|FD-Score:3.34|P-value:3.72E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-3.57|P-value:1.59E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.94|P-value:2.98E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.69|P-value:9.78E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-4.36|P-value:5.50E-6 ID:SGTC_2472|Compound:5377652|FD-Score:5.49|P-value:1.49E-8 ID:SGTC_2479|Compound:5617353|FD-Score:3.70|P-value:9.51E-5 ID:SGTC_2525|Compound:harmine|FD-Score:3.12|P-value:8.02E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.09|P-value:8.95E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:5.59|P-value:8.17E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-10.20|P-value:6.15E-25 ID:SGTC_2678|Compound:equilin|FD-Score:3.26|P-value:5.02E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.38|P-value:3.19E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.75|P-value:7.68E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-3.75|P-value:7.78E-5 ID:SGTC_2912|Compound:7964298|FD-Score:6.52|P-value:2.29E-11 ID:SGTC_2931|Compound:9014674|FD-Score:4.33|P-value:6.10E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-4.15|P-value:1.42E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-4.53|P-value:2.51E-6 ID:SGTC_2939|Compound:9044578|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.35|P-value:5.50E-6 ID:SGTC_2998|Compound:9066762|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.29|P-value:4.42E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.14|P-value:7.77E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.63|P-value:1.25E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.40|P-value:2.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.95|P-value:2.93E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:4.26|P-value:8.32E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.57|P-value:1.58E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.42|P-value:2.73E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.53|P-value:1.81E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.76|P-value:7.20E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.29|P-value:4.59E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.07|P-value:2.02E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.36|P-value:5.27E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.12|P-value:8.35E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.15|P-value:7.38E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.35|P-value:3.55E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.27|P-value:4.77E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.21|P-value:1.07E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:3.25|P-value:5.15E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.26|P-value:5.01E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.69|P-value:9.74E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.25|P-value:5.06E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.58|P-value:1.84E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.17|P-value:1.28E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.64|P-value:1.20E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.81|P-value:6.00E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.09|P-value:9.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.84|P-value:5.37E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.49|P-value:2.95E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.53|P-value:2.34E-6 ID:SGTC_1778|Compound:st046819|FD-Score:3.44|P-value:2.53E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.54|P-value:1.77E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.10|P-value:8.93E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-4.78|P-value:7.00E-7 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.23|P-value:5.68E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_2165|Compound:5727197|FD-Score:5.49|P-value:1.50E-8 ID:SGTC_2192|Compound:5915882|FD-Score:4.17|P-value:1.25E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.20|P-value:6.25E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.16|P-value:7.11E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.86|P-value:4.72E-7 ID:SGTC_2270|Compound:7924575|FD-Score:-3.26|P-value:5.10E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.27|P-value:4.73E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.61|P-value:1.59E-6 ID:SGTC_2342|Compound:7990637|FD-Score:3.34|P-value:3.72E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-3.57|P-value:1.59E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.94|P-value:2.98E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.69|P-value:9.78E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-4.36|P-value:5.50E-6 ID:SGTC_2472|Compound:5377652|FD-Score:5.49|P-value:1.49E-8 ID:SGTC_2479|Compound:5617353|FD-Score:3.70|P-value:9.51E-5 ID:SGTC_2525|Compound:harmine|FD-Score:3.12|P-value:8.02E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.09|P-value:8.95E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:5.59|P-value:8.17E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-10.20|P-value:6.15E-25 ID:SGTC_2678|Compound:equilin|FD-Score:3.26|P-value:5.02E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.38|P-value:3.19E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.75|P-value:7.68E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-3.75|P-value:7.78E-5 ID:SGTC_2912|Compound:7964298|FD-Score:6.52|P-value:2.29E-11 ID:SGTC_2931|Compound:9014674|FD-Score:4.33|P-value:6.10E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-4.15|P-value:1.42E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-4.53|P-value:2.51E-6 ID:SGTC_2939|Compound:9044578|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.35|P-value:5.50E-6 ID:SGTC_2998|Compound:9066762|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.29|P-value:4.42E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.14|P-value:7.77E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.63|P-value:1.25E-4

Top fitness defect scores for YNL091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2912 7964298 6.52 10.9 µM 2.29E-11 cell wall 40 3.46E-11
2 SGTC_2610 ononetin 5.59 44.2 µM 8.17E-9 9 1.11E-8
3 SGTC_2472 5377652 5.49 49.4 µM 1.49E-8 TRP & mitochondrial translation 26 2.01E-8
4 SGTC_2165 5727197 5.49 32.1 µM 1.50E-8 15 2.03E-8
5 SGTC_58 0957-0393 4.95 9.0 µM 2.93E-7 cell wall 288 3.75E-7
6 SGTC_2370 9071495 4.94 200.0 µM 2.98E-7 mitochondrial processes 10 3.82E-7
7 SGTC_2265 7929201 4.86 200.0 µM 4.72E-7 11 5.99E-7
8 SGTC_2296 7971656 4.61 126.5 µM 1.59E-6 29 1.98E-6
9 SGTC_1019 4262-0212 4.58 3.4 µM 1.84E-6 ergosterol depletion effects on membrane 40 2.27E-6
10 SGTC_1745 st081495 4.53 74.0 µM 2.34E-6 RNA processing & uracil transport 59 2.89E-6
11 SGTC_1621 st003705 4.49 32.4 µM 2.95E-6 calcium & mitochondrial duress 13 3.63E-6
12 SGTC_563 tetrahydrosecaminediol 4.36 614.0 µM 5.27E-6 amide catabolism 11 6.41E-6
13 SGTC_2970 9090938 4.35 41.9 µM 5.50E-6 RNA processing & uracil transport 27 6.68E-6
14 SGTC_2931 9014674 4.33 55.7 µM 6.10E-6 15 7.40E-6
15 SGTC_138 0850-0259 4.26 40.9 µM 8.32E-6 cell wall 178 1.00E-5
16 SGTC_710 3448-4187 4.21 58.0 µM 1.07E-5 fatty acid desaturase (OLE1) 50 1.28E-5
17 SGTC_2192 5915882 4.17 198.5 µM 1.25E-5 RNA processing & uracil transport 25 1.49E-5
18 SGTC_1349 flufenamic acid 4.17 69.0 µM 1.28E-5 8 1.53E-5
19 SGTC_467 ro 31-8220 4.07 72.8 µM 2.02E-5 calcium & mitochondrial duress 71 2.40E-5
20 SGTC_1597 7-benzyloxygramine 3.84 47.5 µM 5.37E-5 calcium & mitochondrial duress 129 6.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 1.43E-60 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.186 1.91E-27 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.175 1.54E-24 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.170 4.31E-23 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.162 4.60E-21 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.161 8.00E-21 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.160 1.42E-20 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.158 3.59E-20 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.157 8.65E-20 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.155 1.58E-19 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.154 2.52E-19 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.153 4.05E-19 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.151 1.48E-18 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.149 3.74E-18 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.143 7.92E-17 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins