YNL092W_p

Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL092W / YNL092W

Click on Significant Values for Screen Details ID:SGTC_183|Compound:3914-0051|FD-Score:4.44|P-value:7.81E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:3.20|P-value:2.65E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.89|P-value:9.01E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.16|P-value:3.14E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.96|P-value:9.32E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.32|P-value:1.62E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.34|P-value:1.53E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.18|P-value:2.88E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.42|P-value:1.08E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.98|P-value:6.47E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.97|P-value:6.55E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.34|P-value:1.30E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.10|P-value:4.71E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.17|P-value:3.08E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.05|P-value:4.95E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-2.89|P-value:8.99E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.59|P-value:4.99E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.16|P-value:3.09E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.61|P-value:4.62E-5 ID:SGTC_1691|Compound:st019933|FD-Score:2.88|P-value:8.94E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.07|P-value:4.34E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-6.07|P-value:2.60E-11 ID:SGTC_1744|Compound:st037937|FD-Score:3.22|P-value:2.47E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.52|P-value:6.87E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.47|P-value:8.49E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.31|P-value:1.65E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.31|P-value:1.74E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.47|P-value:6.57E-7 ID:SGTC_3140|Compound:9094243|FD-Score:-5.45|P-value:1.88E-9 ID:SGTC_183|Compound:3914-0051|FD-Score:4.44|P-value:7.81E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:3.20|P-value:2.65E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.89|P-value:9.01E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.16|P-value:3.14E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.96|P-value:9.32E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.32|P-value:1.62E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.34|P-value:1.53E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.18|P-value:2.88E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.42|P-value:1.08E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.98|P-value:6.47E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.97|P-value:6.55E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.34|P-value:1.30E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.10|P-value:4.71E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.17|P-value:3.08E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.05|P-value:4.95E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-2.89|P-value:8.99E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.59|P-value:4.99E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.16|P-value:3.09E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.61|P-value:4.62E-5 ID:SGTC_1691|Compound:st019933|FD-Score:2.88|P-value:8.94E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.07|P-value:4.34E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-6.07|P-value:2.60E-11 ID:SGTC_1744|Compound:st037937|FD-Score:3.22|P-value:2.47E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.52|P-value:6.87E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.47|P-value:8.49E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.31|P-value:1.65E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.31|P-value:1.74E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.47|P-value:6.57E-7 ID:SGTC_3140|Compound:9094243|FD-Score:-5.45|P-value:1.88E-9

Top fitness defect scores for YNL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_183 3914-0051 4.44 30.6 µM 7.81E-7 60S ribosome export 11 4.60E-6
2 SGTC_738 1315-0003 4.34 72.4 µM 1.30E-6 15 7.12E-6
3 SGTC_1525 8-methoxypsoralen 3.61 92.5 µM 4.62E-5 DNA damage response 41 1.53E-4
4 SGTC_1087 pterostilbene 3.59 9.1 µM 4.99E-5 38 1.64E-4
5 SGTC_1974 st069448 3.52 26.9 µM 6.87E-5 37 2.16E-4
6 SGTC_2002 4023503 3.47 131.0 µM 8.49E-5 mitochondrial processes 56 2.59E-4
7 SGTC_506 n9-isopropylolomoucine 3.42 153.0 µM 1.08E-4 25 3.18E-4
8 SGTC_425 3825-7017 3.32 13.1 µM 1.62E-4 44 4.51E-4
9 SGTC_2035 5154463 3.31 94.6 µM 1.65E-4 35 4.59E-4
10 SGTC_473 2-arachidonoylglycerol 3.23 10.0 µM 2.37E-4 39 6.26E-4
11 SGTC_1744 st037937 3.22 38.9 µM 2.47E-4 54 6.50E-4
12 SGTC_203 k066-0004 3.20 30.9 µM 2.65E-4 RSC & ERG11 45 6.90E-4
13 SGTC_1389 3405-0187 3.16 19.0 µM 3.09E-4 42 7.87E-4
14 SGTC_1715 st032160 3.07 10.2 µM 4.34E-4 81 0.00106
15 SGTC_1691 st019933 2.88 84.6 µM 8.94E-4 58 0.00197
16 SGTC_1716 st033144 2.87 30.6 µM 9.36E-4 63 0.00205
17 SGTC_2863 9028737 2.84 58.4 µM 0.00103 30 0.00223
18 SGTC_895 0964-0006 2.82 13.7 µM 0.00111 60 0.00237
19 SGTC_705 1124-0212 2.82 310.0 µM 0.00111 66 0.00238
20 SGTC_810 3825-7150 2.81 143.0 µM 0.00116 60S ribosome export 50 0.00247

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.10E-14 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.115 2.65E-11 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.110 1.76E-10 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.107 5.11E-10 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.105 1.01E-9 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.103 2.07E-9 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.102 2.73E-9 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.099 8.15E-9 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.095 3.12E-8 YNR024W MPP6 hom Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.090 2.03E-7 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.088 3.56E-7 YDR263C DIN7 hom Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
0.084 1.19E-6 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
0.081 2.63E-6 YCL058C FYV5 hom Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
0.080 3.65E-6 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.078 5.31E-6 YFR016C YFR016C hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene