YNL093W / YPT53

Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL093W / YPT53

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.65|P-value:2.77E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.54|P-value:7.14E-6 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.68|P-value:3.89E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:3.58|P-value:3.52E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.27|P-value:2.35E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.51|P-value:4.55E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:5.20|P-value:3.07E-7 ID:SGTC_776|Compound:4476-4378|FD-Score:3.48|P-value:5.08E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.97|P-value:8.06E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.99|P-value:7.33E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:3.79|P-value:1.62E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.69|P-value:2.37E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.82|P-value:1.44E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.30|P-value:2.06E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:4.02|P-value:6.74E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.72|P-value:2.10E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.37|P-value:7.46E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.81|P-value:1.50E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.30|P-value:2.07E-5 ID:SGTC_1625|Compound:st003711|FD-Score:5.06|P-value:6.10E-7 ID:SGTC_1723|Compound:st034307|FD-Score:-3.01|P-value:8.46E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.63|P-value:4.73E-6 ID:SGTC_1887|Compound:st057648|FD-Score:5.34|P-value:1.47E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.47|P-value:5.18E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.11|P-value:4.54E-5 ID:SGTC_1983|Compound:st071813|FD-Score:3.84|P-value:1.37E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.37|P-value:1.23E-7 ID:SGTC_2005|Compound:4024620|FD-Score:5.87|P-value:7.89E-9 ID:SGTC_2012|Compound:4023501|FD-Score:8.02|P-value:3.51E-15 ID:SGTC_2016|Compound:5121758|FD-Score:4.45|P-value:1.08E-5 ID:SGTC_2023|Compound:5144124|FD-Score:4.27|P-value:2.35E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.45|P-value:5.72E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.70|P-value:2.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.40|P-value:6.79E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.56|P-value:3.86E-4 ID:SGTC_2299|Compound:7976368|FD-Score:5.66|P-value:2.59E-8 ID:SGTC_2301|Compound:7769476|FD-Score:3.29|P-value:9.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:8.18|P-value:9.51E-16 ID:SGTC_2326|Compound:6164455|FD-Score:3.60|P-value:3.25E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.52|P-value:4.36E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.33|P-value:8.54E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.82|P-value:1.98E-6 ID:SGTC_2601|Compound:securinine|FD-Score:3.42|P-value:6.23E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.01|P-value:7.75E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.33|P-value:1.52E-7 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.94|P-value:9.17E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.58|P-value:3.53E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.13|P-value:1.72E-9 ID:SGTC_2848|Compound:9016370|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_2854|Compound:9024559|FD-Score:7.09|P-value:3.47E-12 ID:SGTC_2856|Compound:9022925|FD-Score:5.83|P-value:9.69E-9 ID:SGTC_3047|Compound:9092122|FD-Score:-3.56|P-value:1.12E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.36|P-value:7.78E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.65|P-value:2.77E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.54|P-value:7.14E-6 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.68|P-value:3.89E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:3.58|P-value:3.52E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.27|P-value:2.35E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.51|P-value:4.55E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:5.20|P-value:3.07E-7 ID:SGTC_776|Compound:4476-4378|FD-Score:3.48|P-value:5.08E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.97|P-value:8.06E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.99|P-value:7.33E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:3.79|P-value:1.62E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.69|P-value:2.37E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.82|P-value:1.44E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.30|P-value:2.06E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:4.02|P-value:6.74E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.72|P-value:2.10E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.37|P-value:7.46E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.81|P-value:1.50E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.30|P-value:2.07E-5 ID:SGTC_1625|Compound:st003711|FD-Score:5.06|P-value:6.10E-7 ID:SGTC_1723|Compound:st034307|FD-Score:-3.01|P-value:8.46E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.63|P-value:4.73E-6 ID:SGTC_1887|Compound:st057648|FD-Score:5.34|P-value:1.47E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.47|P-value:5.18E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.11|P-value:4.54E-5 ID:SGTC_1983|Compound:st071813|FD-Score:3.84|P-value:1.37E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.37|P-value:1.23E-7 ID:SGTC_2005|Compound:4024620|FD-Score:5.87|P-value:7.89E-9 ID:SGTC_2012|Compound:4023501|FD-Score:8.02|P-value:3.51E-15 ID:SGTC_2016|Compound:5121758|FD-Score:4.45|P-value:1.08E-5 ID:SGTC_2023|Compound:5144124|FD-Score:4.27|P-value:2.35E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.45|P-value:5.72E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.70|P-value:2.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.40|P-value:6.79E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.56|P-value:3.86E-4 ID:SGTC_2299|Compound:7976368|FD-Score:5.66|P-value:2.59E-8 ID:SGTC_2301|Compound:7769476|FD-Score:3.29|P-value:9.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:8.18|P-value:9.51E-16 ID:SGTC_2326|Compound:6164455|FD-Score:3.60|P-value:3.25E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.52|P-value:4.36E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.33|P-value:8.54E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.82|P-value:1.98E-6 ID:SGTC_2601|Compound:securinine|FD-Score:3.42|P-value:6.23E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.01|P-value:7.75E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.33|P-value:1.52E-7 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.94|P-value:9.17E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.58|P-value:3.53E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.13|P-value:1.72E-9 ID:SGTC_2848|Compound:9016370|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_2854|Compound:9024559|FD-Score:7.09|P-value:3.47E-12 ID:SGTC_2856|Compound:9022925|FD-Score:5.83|P-value:9.69E-9 ID:SGTC_3047|Compound:9092122|FD-Score:-3.56|P-value:1.12E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.36|P-value:7.78E-4

Top fitness defect scores for YNL093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2320 7373003 8.18 200.0 µM 9.51E-16 1 1.37E-16
2 SGTC_2012 4023501 8.02 200.0 µM 3.51E-15 2 5.32E-16
3 SGTC_2854 9024559 7.09 71.4 µM 3.47E-12 2 6.94E-13
4 SGTC_2833 9001315 6.13 45.5 µM 1.72E-9 amide catabolism 16 4.47E-10
5 SGTC_2005 4024620 5.87 188.0 µM 7.89E-9 4 2.21E-9
6 SGTC_2856 9022925 5.83 19.5 µM 9.69E-9 6 2.73E-9
7 SGTC_2299 7976368 5.66 114.9 µM 2.59E-8 11 7.64E-9
8 SGTC_2003 4023581 5.37 200.0 µM 1.23E-7 cell wall signaling 17 3.92E-8
9 SGTC_1887 st057648 5.34 70.8 µM 1.47E-7 1 4.73E-8
10 SGTC_2758 dehydroepiandrosterone 5.33 69.3 µM 1.52E-7 21 4.87E-8
11 SGTC_723 4182-0001 5.20 115.0 µM 3.07E-7 15 1.02E-7
12 SGTC_1625 st003711 5.06 30.1 µM 6.10E-7 calcium & mitochondrial duress 18 2.10E-7
13 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.01 100.0 µM 7.75E-7 18 2.69E-7
14 SGTC_2596 sinensetin 4.82 100.0 µM 1.98E-6 15 7.23E-7
15 SGTC_231 b-estradiol 4.68 524.0 µM 3.89E-6 3 1.46E-6
16 SGTC_1885 st057546 4.63 99.9 µM 4.73E-6 9 1.80E-6
17 SGTC_184 1494-0393 4.54 24.7 µM 7.14E-6 47 2.78E-6
18 SGTC_2016 5121758 4.45 140.0 µM 1.08E-5 redox potentiating 32 4.29E-6
19 SGTC_964 1287-0107 4.30 19.4 µM 2.06E-5 cell wall 29 8.47E-6
20 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.30 61.9 µM 2.07E-5 10 8.52E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.59E-10 YLR460C_p YLR460C_p hom Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine
0.095 3.99E-8 YPL122C TFB2 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
0.093 6.82E-8 YIL163C_p YIL163C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.090 1.69E-7 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.090 2.07E-7 YPL032C SVL3 hom Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.089 2.46E-7 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.083 1.35E-6 YBL091C MAP2 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
0.080 3.20E-6 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.079 4.34E-6 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.079 4.55E-6 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.078 6.16E-6 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.077 7.41E-6 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.076 9.61E-6 YIL101C XBP1 hom Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.073 2.03E-5 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.071 4.47E-5 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress