YNL095C_p

Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL095C / YNL095C

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:4.16|P-value:1.20E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.37|P-value:4.47E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:4.27|P-value:7.27E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.35|P-value:4.89E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.76|P-value:7.14E-5 ID:SGTC_269|Compound:exalamide|FD-Score:3.59|P-value:1.30E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-4.66|P-value:1.19E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:3.95|P-value:3.02E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.48|P-value:2.04E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.34|P-value:3.55E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.02|P-value:2.17E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.19|P-value:5.86E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.97|P-value:2.77E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.06|P-value:9.37E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.84|P-value:4.79E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.43|P-value:2.55E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.48|P-value:1.98E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.15|P-value:6.77E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.71|P-value:8.37E-7 ID:SGTC_1746|Compound:st038117|FD-Score:3.42|P-value:2.49E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.11|P-value:1.46E-5 ID:SGTC_1897|Compound:st060201|FD-Score:8.14|P-value:7.06E-17 ID:SGTC_1998|Compound:st075797|FD-Score:3.96|P-value:2.82E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.70|P-value:9.12E-5 ID:SGTC_2460|Compound:5552655|FD-Score:3.12|P-value:7.53E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.15|P-value:6.87E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.02|P-value:2.24E-5 ID:SGTC_2914|Compound:7968218|FD-Score:3.47|P-value:2.07E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.92|P-value:3.37E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.69|P-value:8.91E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.06|P-value:9.77E-4 ID:SGTC_3150|Compound:9097574|FD-Score:5.12|P-value:1.01E-7 ID:SGTC_3271|Compound:9137798|FD-Score:3.89|P-value:3.78E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:4.16|P-value:1.20E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.37|P-value:4.47E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:4.27|P-value:7.27E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.35|P-value:4.89E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.76|P-value:7.14E-5 ID:SGTC_269|Compound:exalamide|FD-Score:3.59|P-value:1.30E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-4.66|P-value:1.19E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:3.95|P-value:3.02E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.48|P-value:2.04E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.34|P-value:3.55E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.02|P-value:2.17E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.19|P-value:5.86E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.97|P-value:2.77E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.06|P-value:9.37E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.84|P-value:4.79E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.43|P-value:2.55E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.48|P-value:1.98E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.15|P-value:6.77E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.71|P-value:8.37E-7 ID:SGTC_1746|Compound:st038117|FD-Score:3.42|P-value:2.49E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.11|P-value:1.46E-5 ID:SGTC_1897|Compound:st060201|FD-Score:8.14|P-value:7.06E-17 ID:SGTC_1998|Compound:st075797|FD-Score:3.96|P-value:2.82E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.70|P-value:9.12E-5 ID:SGTC_2460|Compound:5552655|FD-Score:3.12|P-value:7.53E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.15|P-value:6.87E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.02|P-value:2.24E-5 ID:SGTC_2914|Compound:7968218|FD-Score:3.47|P-value:2.07E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.92|P-value:3.37E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.69|P-value:8.91E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.06|P-value:9.77E-4 ID:SGTC_3150|Compound:9097574|FD-Score:5.12|P-value:1.01E-7 ID:SGTC_3271|Compound:9137798|FD-Score:3.89|P-value:3.78E-5

Top fitness defect scores for YNL095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1897 st060201 8.14 15.0 µM 7.06E-17 mitochondrial processes 2 2.01E-16
2 SGTC_3150 9097574 5.12 49.5 µM 1.01E-7 4 1.55E-7
3 SGTC_1576 erythromycin ethylsuccinate 4.71 23.2 µM 8.37E-7 11 1.22E-6
4 SGTC_151 3013-0144 4.37 2.3 µM 4.47E-6 iron homeostasis 18 6.19E-6
5 SGTC_238 5hr heat shock (37°C) + nsc-638432 4.35 8.9 µM 4.89E-6 heat shock/prefoldin 30 6.76E-6
6 SGTC_198 3454-2873 4.27 16.2 µM 7.27E-6 60S ribosome export 10 9.94E-6
7 SGTC_20 0481-0013 4.16 4.9 µM 1.20E-5 17 1.62E-5
8 SGTC_1855 st056195 4.11 39.6 µM 1.46E-5 60S ribosome export 14 1.95E-5
9 SGTC_479 n-linoleoylglycine 4.02 10.0 µM 2.17E-5 10 2.87E-5
10 SGTC_2913 7966556 4.02 36.6 µM 2.24E-5 60S ribosome export 11 2.96E-5
11 SGTC_655 k060-0012 3.97 42.0 µM 2.77E-5 11 3.64E-5
12 SGTC_1998 st075797 3.96 76.8 µM 2.82E-5 mitochondrial response to ROS 16 3.71E-5
13 SGTC_367 0335-0881 3.95 7.1 µM 3.02E-5 ubiquinone biosynthesis & proteasome 81 3.96E-5
14 SGTC_2933 9026794 3.92 32.5 µM 3.37E-5 19 4.41E-5
15 SGTC_3271 9137798 3.89 49.5 µM 3.78E-5 6 4.93E-5
16 SGTC_1251 0490-5699 3.84 265.0 µM 4.79E-5 36 6.20E-5
17 SGTC_2968 9090663 3.69 33.4 µM 8.91E-5 40 1.13E-4
18 SGTC_2406 ethylparaben 3.65 405.7 µM 1.02E-4 56 1.29E-4
19 SGTC_1205 4161-2785 3.65 76.0 µM 1.02E-4 39 1.29E-4
20 SGTC_269 exalamide 3.59 29.0 µM 1.30E-4 ergosterol biosynthesis 29 1.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.46E-17 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.112 9.27E-11 YNL191W DUG3 hom Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
0.103 2.52E-9 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.088 3.25E-7 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.087 4.66E-7 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.082 1.77E-6 YER143W DDI1 hom DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
0.082 2.27E-6 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.077 6.97E-6 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.075 1.22E-5 YJL048C UBX6 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication
0.074 1.74E-5 YCR060W TAH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.073 2.36E-5 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.42E-5 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.073 2.53E-5 YER037W PHM8 hom Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p
0.071 3.86E-5 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.071 4.21E-5 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency