YNL097C / PHO23

Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL097C / PHO23

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.11|P-value:8.43E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:5.57|P-value:1.14E-8 ID:SGTC_36|Compound:0335-0881|FD-Score:4.94|P-value:3.57E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.35|P-value:3.65E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.12|P-value:8.23E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.33|P-value:4.59E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.32|P-value:4.03E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.72|P-value:8.96E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.42|P-value:4.51E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:3.40|P-value:2.98E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.49|P-value:2.21E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.46|P-value:2.41E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.47|P-value:3.54E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:4.85|P-value:5.72E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:4.32|P-value:7.07E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.57|P-value:1.60E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.92|P-value:5.96E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.35|P-value:3.95E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.55|P-value:2.47E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.62|P-value:8.59E-9 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.78|P-value:3.48E-9 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.26|P-value:9.24E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.25|P-value:5.25E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.09|P-value:9.14E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.40|P-value:3.00E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.67|P-value:1.33E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.46|P-value:2.39E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.57|P-value:2.22E-6 ID:SGTC_1992|Compound:st073643|FD-Score:4.05|P-value:2.28E-5 ID:SGTC_2007|Compound:4011539|FD-Score:5.82|P-value:2.68E-9 ID:SGTC_2024|Compound:5144227|FD-Score:3.22|P-value:5.71E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.97|P-value:3.29E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.07|P-value:9.55E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.96|P-value:3.16E-7 ID:SGTC_2289|Compound:7946404|FD-Score:4.91|P-value:4.15E-7 ID:SGTC_2310|Compound:7668677|FD-Score:3.09|P-value:9.05E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.48|P-value:3.33E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.21|P-value:8.50E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.28|P-value:4.61E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.34|P-value:6.52E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.00|P-value:2.87E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.19|P-value:8.98E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.84|P-value:5.46E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.24|P-value:7.72E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.52|P-value:2.83E-4 ID:SGTC_2815|Compound:7968870|FD-Score:6.73|P-value:7.90E-12 ID:SGTC_2821|Compound:7996764|FD-Score:6.95|P-value:1.69E-12 ID:SGTC_2853|Compound:9015042|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.03|P-value:2.51E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.90|P-value:6.53E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.66|P-value:1.14E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.45|P-value:2.48E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.33|P-value:3.95E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.11|P-value:8.43E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:5.57|P-value:1.14E-8 ID:SGTC_36|Compound:0335-0881|FD-Score:4.94|P-value:3.57E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.35|P-value:3.65E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.12|P-value:8.23E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.33|P-value:4.59E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.32|P-value:4.03E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.72|P-value:8.96E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.42|P-value:4.51E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:3.40|P-value:2.98E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.49|P-value:2.21E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.46|P-value:2.41E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.47|P-value:3.54E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:4.85|P-value:5.72E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:4.32|P-value:7.07E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.57|P-value:1.60E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.92|P-value:5.96E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.35|P-value:3.95E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.55|P-value:2.47E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.62|P-value:8.59E-9 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.78|P-value:3.48E-9 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.26|P-value:9.24E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.25|P-value:5.25E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.09|P-value:9.14E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.40|P-value:3.00E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.67|P-value:1.33E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.46|P-value:2.39E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.57|P-value:2.22E-6 ID:SGTC_1992|Compound:st073643|FD-Score:4.05|P-value:2.28E-5 ID:SGTC_2007|Compound:4011539|FD-Score:5.82|P-value:2.68E-9 ID:SGTC_2024|Compound:5144227|FD-Score:3.22|P-value:5.71E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.97|P-value:3.29E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.07|P-value:9.55E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.96|P-value:3.16E-7 ID:SGTC_2289|Compound:7946404|FD-Score:4.91|P-value:4.15E-7 ID:SGTC_2310|Compound:7668677|FD-Score:3.09|P-value:9.05E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.48|P-value:3.33E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.21|P-value:8.50E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.28|P-value:4.61E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.34|P-value:6.52E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.00|P-value:2.87E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.19|P-value:8.98E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.84|P-value:5.46E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.24|P-value:7.72E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.52|P-value:2.83E-4 ID:SGTC_2815|Compound:7968870|FD-Score:6.73|P-value:7.90E-12 ID:SGTC_2821|Compound:7996764|FD-Score:6.95|P-value:1.69E-12 ID:SGTC_2853|Compound:9015042|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.03|P-value:2.51E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.90|P-value:6.53E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.66|P-value:1.14E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.45|P-value:2.48E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.33|P-value:3.95E-4

Top fitness defect scores for YNL097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2821 7996764 6.95 71.4 µM 1.69E-12 2 1.76E-12
2 SGTC_2815 7968870 6.73 71.4 µM 7.90E-12 4 8.31E-12
3 SGTC_2007 4011539 5.82 71.8 µM 2.68E-9 cell wall signaling 26 2.90E-9
4 SGTC_1320 1313-0481 5.78 95.3 µM 3.48E-9 7 3.78E-9
5 SGTC_1135 dihydrocapsaicin 5.62 536.7 nM 8.59E-9 8 9.36E-9
6 SGTC_31 0508-1974 5.57 57.2 µM 1.14E-8 4 1.24E-8
7 SGTC_1133 3473-0247 5.35 50.0 µM 3.95E-8 RSC complex & mRNA processing 16 4.32E-8
8 SGTC_158 k038-0087 5.33 26.4 µM 4.59E-8 ubiquinone biosynthesis & proteasome 84 5.03E-8
9 SGTC_2129 girgensonine 4.96 121.0 µM 3.16E-7 heme biosynthesis & mitochondrial translocase 17 3.49E-7
10 SGTC_36 0335-0881 4.94 14.2 µM 3.57E-7 ubiquinone biosynthesis & proteasome 82 3.94E-7
11 SGTC_2289 7946404 4.91 165.1 µM 4.15E-7 58 4.59E-7
12 SGTC_927 2425-1185 4.85 123.0 µM 5.72E-7 8 6.32E-7
13 SGTC_1538 2',3',6-trimethoxyflavanone 4.67 63.6 µM 1.33E-6 8 1.48E-6
14 SGTC_1824 st053723 4.57 68.6 µM 2.22E-6 18 2.46E-6
15 SGTC_1134 3477-0009 4.55 42.5 µM 2.47E-6 31 2.74E-6
16 SGTC_2312 7706453 4.48 155.7 µM 3.33E-6 20 3.70E-6
17 SGTC_891 0929-0073 4.47 133.0 µM 3.54E-6 13 3.93E-6
18 SGTC_605 1315-0399 4.42 119.0 µM 4.51E-6 Golgi 16 5.01E-6
19 SGTC_2416 tofa 4.34 880.0 nM 6.52E-6 sphingolipid biosynthesis & PDR1 39 7.25E-6
20 SGTC_960 1222-0186 4.32 7.7 µM 7.07E-6 24 7.86E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.03E-22 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.159 1.62E-20 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.148 8.19E-18 YMR263W SAP30 hom Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
0.137 1.38E-15 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.129 6.17E-14 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.125 4.28E-13 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.124 4.91E-13 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.124 5.83E-13 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.123 8.00E-13 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.121 2.01E-12 YMR268C PRP24 het Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
0.113 4.43E-11 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.113 4.72E-11 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 8.77E-11 YOL004W SIN3 hom Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
0.110 1.69E-10 YAL013W DEP1 hom Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
0.110 1.84E-10 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones