YNL097C-B_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL097C-B / YNL097C-B

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.46|P-value:9.78E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:2.97|P-value:5.96E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.37|P-value:1.42E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.31|P-value:1.52E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:1.59E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:5.65|P-value:4.19E-10 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:3.80E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-2.98|P-value:6.76E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.36|P-value:1.51E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.05|P-value:5.12E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.45|P-value:8.63E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.49|P-value:7.00E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.96|P-value:8.01E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:3.56|P-value:5.30E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.43|P-value:9.45E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.89|P-value:1.13E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.59|P-value:5.52E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.77|P-value:1.08E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.51|P-value:1.04E-9 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.10|P-value:3.65E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.15|P-value:2.98E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.80|P-value:1.74E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.22|P-value:2.24E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.50|P-value:8.12E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.83|P-value:9.90E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.91|P-value:1.29E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.19|P-value:2.96E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-4.55|P-value:4.61E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.01|P-value:6.09E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.43|P-value:1.11E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-2.96|P-value:7.18E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-8.96|P-value:1.89E-22 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.35|P-value:1.30E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.87|P-value:1.57E-5 ID:SGTC_1971|Compound:st069429|FD-Score:-3.28|P-value:2.10E-4 ID:SGTC_1995|Compound:st072814|FD-Score:2.99|P-value:5.45E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.28|P-value:1.58E-6 ID:SGTC_2263|Compound:7948595|FD-Score:-3.49|P-value:8.71E-5 ID:SGTC_2364|Compound:9055074|FD-Score:3.21|P-value:2.33E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.87|P-value:1.22E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:2.87|P-value:8.74E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.53|P-value:6.00E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.71|P-value:2.70E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-4.10|P-value:5.01E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.55|P-value:5.51E-5 ID:SGTC_3011|Compound:9081274|FD-Score:-2.88|P-value:9.95E-4 ID:SGTC_3019|Compound:9081971|FD-Score:2.92|P-value:7.10E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.89|P-value:1.16E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.04|P-value:5.37E-4 ID:SGTC_3163|Compound:9099914|FD-Score:2.91|P-value:7.38E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.54|P-value:3.91E-7 ID:SGTC_3210|Compound:9128157|FD-Score:-4.62|P-value:3.25E-7 ID:SGTC_3222|Compound:9128301|FD-Score:3.13|P-value:3.23E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.43|P-value:1.12E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.46|P-value:9.78E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:2.97|P-value:5.96E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.37|P-value:1.42E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.31|P-value:1.52E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:1.59E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:5.65|P-value:4.19E-10 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:3.80E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-2.98|P-value:6.76E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.36|P-value:1.51E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.05|P-value:5.12E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.45|P-value:8.63E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.49|P-value:7.00E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.96|P-value:8.01E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:3.56|P-value:5.30E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.43|P-value:9.45E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.89|P-value:1.13E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.59|P-value:5.52E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.77|P-value:1.08E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.51|P-value:1.04E-9 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.10|P-value:3.65E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.15|P-value:2.98E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.80|P-value:1.74E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.22|P-value:2.24E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.50|P-value:8.12E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.83|P-value:9.90E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.91|P-value:1.29E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.19|P-value:2.96E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-4.55|P-value:4.61E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.01|P-value:6.09E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.43|P-value:1.11E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-2.96|P-value:7.18E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-8.96|P-value:1.89E-22 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.35|P-value:1.30E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.87|P-value:1.57E-5 ID:SGTC_1971|Compound:st069429|FD-Score:-3.28|P-value:2.10E-4 ID:SGTC_1995|Compound:st072814|FD-Score:2.99|P-value:5.45E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.28|P-value:1.58E-6 ID:SGTC_2263|Compound:7948595|FD-Score:-3.49|P-value:8.71E-5 ID:SGTC_2364|Compound:9055074|FD-Score:3.21|P-value:2.33E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.87|P-value:1.22E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:2.87|P-value:8.74E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.53|P-value:6.00E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.71|P-value:2.70E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-4.10|P-value:5.01E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.55|P-value:5.51E-5 ID:SGTC_3011|Compound:9081274|FD-Score:-2.88|P-value:9.95E-4 ID:SGTC_3019|Compound:9081971|FD-Score:2.92|P-value:7.10E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.89|P-value:1.16E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.04|P-value:5.37E-4 ID:SGTC_3163|Compound:9099914|FD-Score:2.91|P-value:7.38E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.54|P-value:3.91E-7 ID:SGTC_3210|Compound:9128157|FD-Score:-4.62|P-value:3.25E-7 ID:SGTC_3222|Compound:9128301|FD-Score:3.13|P-value:3.23E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.43|P-value:1.12E-4

Top fitness defect scores for YNL097C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_359 0081-0058 5.65 15.9 µM 4.19E-10 60S ribosome export 11 8.23E-9
2 SGTC_1134 3477-0009 5.51 42.5 µM 1.04E-9 13 1.78E-8
3 SGTC_1131 3454-3128 4.77 32.3 µM 1.08E-7 18 9.43E-7
4 SGTC_3165 9101544 4.54 49.5 µM 3.91E-7 6 2.82E-6
5 SGTC_2078 5212016 4.28 200.0 µM 1.58E-6 60S ribosome export 10 9.27E-6
6 SGTC_757 1066-0008 3.96 322.0 µM 8.01E-6 Golgi 18 3.72E-5
7 SGTC_1006 4099-6547 3.89 255.0 µM 1.13E-5 22 5.01E-5
8 SGTC_3102 9121669 3.89 49.5 µM 1.16E-5 11 5.09E-5
9 SGTC_2704 st078022 3.87 71.1 µM 1.22E-5 14 5.34E-5
10 SGTC_1314 1222-0010 3.80 41.1 µM 1.74E-5 14 7.20E-5
11 SGTC_2768 sulfasalazine 3.71 50.2 µM 2.70E-5 23 1.05E-4
12 SGTC_835 0312-0010 3.56 67.2 µM 5.30E-5 20 1.87E-4
13 SGTC_2925 9010536 3.55 32.5 µM 5.51E-5 azole & statin 67 1.94E-4
14 SGTC_2762 leflunomide 3.53 42.1 µM 6.00E-5 47 2.08E-4
15 SGTC_753 1322-0200 3.49 289.0 µM 7.00E-5 35 2.37E-4
16 SGTC_741 4582-0002 3.45 126.0 µM 8.63E-5 25 2.84E-4
17 SGTC_1003 4049-0218 3.43 100.0 µM 9.45E-5 36 3.07E-4
18 SGTC_1929 genistein trimethyl ether 3.35 50.5 µM 1.30E-4 35 4.04E-4
19 SGTC_1127 asiatic acid 3.33 681.4 nM 1.43E-4 44 4.37E-4
20 SGTC_58 0957-0393 3.31 9.0 µM 1.52E-4 cell wall 451 4.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 1.64E-35 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.172 8.40E-24 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.168 1.17E-22 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.164 1.53E-21 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.161 6.61E-21 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.153 5.69E-19 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.151 1.53E-18 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.151 1.68E-18 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.149 3.84E-18 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.147 1.18E-17 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.145 3.82E-17 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.143 7.07E-17 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.143 8.17E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.142 1.45E-16 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.139 5.59E-16 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2