YNL099C / OCA1

Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL099C / OCA1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.44|P-value:1.10E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:7.12|P-value:4.52E-12 ID:SGTC_14|Compound:0354-0009|FD-Score:3.37|P-value:6.45E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.90|P-value:7.79E-9 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.42|P-value:5.48E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.20|P-value:2.91E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:6.42|P-value:3.79E-10 ID:SGTC_75|Compound:0159-0059|FD-Score:3.73|P-value:1.82E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.59|P-value:3.04E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.36|P-value:6.68E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.21|P-value:2.85E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:6.99|P-value:1.02E-11 ID:SGTC_216|Compound:k038-0035|FD-Score:5.12|P-value:4.73E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.86|P-value:1.63E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.69|P-value:2.14E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.65|P-value:2.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:5.84|P-value:1.09E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.02|P-value:4.89E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.62|P-value:4.85E-6 ID:SGTC_587|Compound:k089-0003|FD-Score:4.08|P-value:4.88E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.33|P-value:7.33E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.51|P-value:4.04E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.72|P-value:1.89E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.79|P-value:1.49E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.25|P-value:9.65E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.38|P-value:6.17E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.44|P-value:5.05E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.32|P-value:1.83E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:4.98|P-value:9.29E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:4.96|P-value:1.03E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:3.40|P-value:5.78E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.09|P-value:4.59E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:4.87|P-value:1.60E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:4.55|P-value:6.67E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:4.00|P-value:6.49E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:4.38|P-value:1.38E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.17|P-value:3.34E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.90|P-value:9.54E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.97|P-value:7.38E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.49|P-value:8.58E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:5.93|P-value:6.66E-9 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.31|P-value:1.81E-7 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.35|P-value:6.98E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:4.26E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.49|P-value:7.43E-8 ID:SGTC_1518|Compound:st038567|FD-Score:6.70|P-value:6.70E-11 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.95|P-value:8.13E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:7.12|P-value:4.43E-12 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.39|P-value:1.07E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:5.09|P-value:5.61E-7 ID:SGTC_1717|Compound:st033143|FD-Score:12.70|P-value:1.88E-34 ID:SGTC_1719|Compound:st032227|FD-Score:6.03|P-value:3.79E-9 ID:SGTC_1767|Compound:st044992|FD-Score:4.76|P-value:2.60E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.42|P-value:5.40E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.28|P-value:8.72E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.10|P-value:4.47E-5 ID:SGTC_2014|Compound:4013930|FD-Score:-3.90|P-value:7.82E-5 ID:SGTC_2024|Compound:5144227|FD-Score:8.41|P-value:3.65E-16 ID:SGTC_2025|Compound:5147754|FD-Score:3.73|P-value:1.81E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.36|P-value:6.67E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.34|P-value:7.20E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.31|P-value:6.48E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.31|P-value:6.60E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.52|P-value:3.92E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.76|P-value:1.65E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.28|P-value:8.63E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.43|P-value:1.14E-5 ID:SGTC_2585|Compound:alliin|FD-Score:5.86|P-value:1.02E-8 ID:SGTC_2781|Compound:5567276|FD-Score:3.36|P-value:6.75E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.49|P-value:3.57E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.10|P-value:4.53E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.25|P-value:8.03E-4 ID:SGTC_2871|Compound:9038510|FD-Score:4.58|P-value:5.99E-6 ID:SGTC_2880|Compound:9042983|FD-Score:3.79|P-value:1.46E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.70|P-value:2.04E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.01|P-value:6.36E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.29|P-value:8.43E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.26|P-value:9.44E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.34|P-value:7.24E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.33|P-value:7.49E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.71|P-value:1.58E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.29|P-value:8.49E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.58|P-value:5.91E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.66|P-value:2.35E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.25|P-value:9.78E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.44|P-value:1.10E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:7.12|P-value:4.52E-12 ID:SGTC_14|Compound:0354-0009|FD-Score:3.37|P-value:6.45E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.90|P-value:7.79E-9 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.42|P-value:5.48E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.20|P-value:2.91E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:6.42|P-value:3.79E-10 ID:SGTC_75|Compound:0159-0059|FD-Score:3.73|P-value:1.82E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.59|P-value:3.04E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.36|P-value:6.68E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.21|P-value:2.85E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:6.99|P-value:1.02E-11 ID:SGTC_216|Compound:k038-0035|FD-Score:5.12|P-value:4.73E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.86|P-value:1.63E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.69|P-value:2.14E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.65|P-value:2.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:5.84|P-value:1.09E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.02|P-value:4.89E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.62|P-value:4.85E-6 ID:SGTC_587|Compound:k089-0003|FD-Score:4.08|P-value:4.88E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.33|P-value:7.33E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.51|P-value:4.04E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.72|P-value:1.89E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.79|P-value:1.49E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.25|P-value:9.65E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.38|P-value:6.17E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.44|P-value:5.05E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.32|P-value:1.83E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:4.98|P-value:9.29E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:4.96|P-value:1.03E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:3.40|P-value:5.78E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.09|P-value:4.59E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:4.87|P-value:1.60E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:4.55|P-value:6.67E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:4.00|P-value:6.49E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:4.38|P-value:1.38E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.17|P-value:3.34E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.90|P-value:9.54E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.97|P-value:7.38E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.49|P-value:8.58E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:5.93|P-value:6.66E-9 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.31|P-value:1.81E-7 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.35|P-value:6.98E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:4.26E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.49|P-value:7.43E-8 ID:SGTC_1518|Compound:st038567|FD-Score:6.70|P-value:6.70E-11 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.95|P-value:8.13E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:7.12|P-value:4.43E-12 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.39|P-value:1.07E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:5.09|P-value:5.61E-7 ID:SGTC_1717|Compound:st033143|FD-Score:12.70|P-value:1.88E-34 ID:SGTC_1719|Compound:st032227|FD-Score:6.03|P-value:3.79E-9 ID:SGTC_1767|Compound:st044992|FD-Score:4.76|P-value:2.60E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.42|P-value:5.40E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.28|P-value:8.72E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.10|P-value:4.47E-5 ID:SGTC_2014|Compound:4013930|FD-Score:-3.90|P-value:7.82E-5 ID:SGTC_2024|Compound:5144227|FD-Score:8.41|P-value:3.65E-16 ID:SGTC_2025|Compound:5147754|FD-Score:3.73|P-value:1.81E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.36|P-value:6.67E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.34|P-value:7.20E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.31|P-value:6.48E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.31|P-value:6.60E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.52|P-value:3.92E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.76|P-value:1.65E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.28|P-value:8.63E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.43|P-value:1.14E-5 ID:SGTC_2585|Compound:alliin|FD-Score:5.86|P-value:1.02E-8 ID:SGTC_2781|Compound:5567276|FD-Score:3.36|P-value:6.75E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.49|P-value:3.57E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.10|P-value:4.53E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.25|P-value:8.03E-4 ID:SGTC_2871|Compound:9038510|FD-Score:4.58|P-value:5.99E-6 ID:SGTC_2880|Compound:9042983|FD-Score:3.79|P-value:1.46E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.70|P-value:2.04E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.01|P-value:6.36E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.29|P-value:8.43E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.26|P-value:9.44E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.34|P-value:7.24E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.33|P-value:7.49E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.71|P-value:1.58E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.29|P-value:8.49E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.58|P-value:5.91E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.66|P-value:2.35E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.25|P-value:9.78E-4

Top fitness defect scores for YNL099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 12.70 58.0 µM 1.88E-34 2 3.45E-37
2 SGTC_2024 5144227 8.41 134.0 µM 3.65E-16 7 2.08E-17
3 SGTC_1532 4',5'-dihydroxyflavone 7.12 78.7 µM 4.43E-12 Golgi 3 5.47E-13
4 SGTC_8 0354-0001 7.12 70.0 µM 4.52E-12 17 5.59E-13
5 SGTC_174 3553-0389 6.99 74.3 µM 1.02E-11 1 1.35E-12
6 SGTC_1518 st038567 6.70 90.8 µM 6.70E-11 1 1.03E-11
7 SGTC_52 0329-0193 6.42 875.0 nM 3.79E-10 TSC3-RPN4 8 6.75E-11
8 SGTC_1719 st032227 6.03 49.2 µM 3.79E-9 5 8.15E-10
9 SGTC_1292 0kpi-0043 5.93 232.0 µM 6.66E-9 2 1.50E-9
10 SGTC_18 0111-0177 5.90 500.0 nM 7.79E-9 21 1.78E-9
11 SGTC_2585 alliin 5.86 100.0 µM 1.02E-8 7 2.38E-9
12 SGTC_516 3992-2719 5.84 87.3 µM 1.09E-8 5 2.56E-9
13 SGTC_1514 1189-1591 5.49 158.0 µM 7.43E-8 14 2.04E-8
14 SGTC_1304 1165-0502 5.31 251.0 µM 1.81E-7 40 5.34E-8
15 SGTC_216 k038-0035 5.12 28.4 µM 4.73E-7 ubiquinone biosynthesis & proteasome 34 1.51E-7
16 SGTC_1693 xanthone 5.09 101.9 µM 5.61E-7 DNA damage response 5 1.82E-7
17 SGTC_747 3448-8087 4.98 38.7 µM 9.29E-7 9 3.14E-7
18 SGTC_751 0833-0568 4.96 350.0 µM 1.03E-6 7 3.51E-7
19 SGTC_786 4544-0069 4.87 423.0 µM 1.60E-6 14 5.65E-7
20 SGTC_402 epigallocatechin gallate 4.86 10.0 µM 1.63E-6 6 5.76E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 2.36E-27 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.138 1.24E-15 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.131 2.27E-14 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.104 1.73E-9 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.102 3.06E-9 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.101 5.39E-9 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.100 6.27E-9 YPL166W ATG29 hom Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.100 7.45E-9 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.099 8.59E-9 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.098 1.37E-8 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.094 5.12E-8 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.091 1.20E-7 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.088 3.66E-7 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.088 3.82E-7 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.087 4.85E-7 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth