YNL100W / AIM37

Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL100W / AIM37

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-5.11|P-value:7.85E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:6.07|P-value:6.72E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.15|P-value:9.29E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.22|P-value:4.35E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.35|P-value:4.60E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.80|P-value:8.33E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.19|P-value:4.80E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.11|P-value:6.34E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.26|P-value:6.38E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.48|P-value:4.16E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.18|P-value:8.39E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.74|P-value:1.18E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.43|P-value:3.48E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.16|P-value:9.14E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.11|P-value:6.31E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.00|P-value:9.22E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:7.08|P-value:7.15E-13 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.33|P-value:8.54E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.80|P-value:8.32E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.27|P-value:6.11E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.61|P-value:2.31E-6 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.99|P-value:3.81E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.28|P-value:6.05E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.49|P-value:2.76E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.86|P-value:6.47E-5 ID:SGTC_1808|Compound:st050063|FD-Score:4.77|P-value:1.03E-6 ID:SGTC_1862|Compound:st057513|FD-Score:3.99|P-value:3.73E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.37|P-value:4.36E-8 ID:SGTC_1961|Compound:st076550|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.66|P-value:1.44E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.76|P-value:9.72E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.43|P-value:3.51E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.62|P-value:2.16E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:3.73|P-value:1.11E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.28|P-value:5.89E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.10|P-value:6.50E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.64|P-value:2.00E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.20|P-value:8.02E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.28|P-value:6.07E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.06|P-value:7.66E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.42|P-value:3.55E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.21|P-value:4.54E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.24|P-value:3.97E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.67|P-value:7.54E-5 ID:SGTC_3118|Compound:9124250|FD-Score:4.20|P-value:1.54E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.60|P-value:1.81E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.98|P-value:3.52E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.11|P-value:7.85E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:6.07|P-value:6.72E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.15|P-value:9.29E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.22|P-value:4.35E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.35|P-value:4.60E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.80|P-value:8.33E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.19|P-value:4.80E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.11|P-value:6.34E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.26|P-value:6.38E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.48|P-value:4.16E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.18|P-value:8.39E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.74|P-value:1.18E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.43|P-value:3.48E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.16|P-value:9.14E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.11|P-value:6.31E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.00|P-value:9.22E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:7.08|P-value:7.15E-13 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.33|P-value:8.54E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.80|P-value:8.32E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.27|P-value:6.11E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.61|P-value:2.31E-6 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.99|P-value:3.81E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.28|P-value:6.05E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.49|P-value:2.76E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.86|P-value:6.47E-5 ID:SGTC_1808|Compound:st050063|FD-Score:4.77|P-value:1.03E-6 ID:SGTC_1862|Compound:st057513|FD-Score:3.99|P-value:3.73E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.37|P-value:4.36E-8 ID:SGTC_1961|Compound:st076550|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.66|P-value:1.44E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.76|P-value:9.72E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.43|P-value:3.51E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.62|P-value:2.16E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:3.73|P-value:1.11E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.28|P-value:5.89E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.10|P-value:6.50E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.64|P-value:2.00E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.20|P-value:8.02E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.28|P-value:6.07E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.06|P-value:7.66E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.42|P-value:3.55E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.21|P-value:4.54E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.24|P-value:3.97E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.67|P-value:7.54E-5 ID:SGTC_3118|Compound:9124250|FD-Score:4.20|P-value:1.54E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.60|P-value:1.81E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.98|P-value:3.52E-7

Top fitness defect scores for YNL100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 7.08 424.9 nM 7.15E-13 DNA damage response 16 7.23E-13
2 SGTC_45 0kpi-0036 6.07 14.9 µM 6.72E-10 excess fatty acid 4 6.33E-10
3 SGTC_1959 st077091 5.37 55.8 µM 4.36E-8 RPP1 & pyrimidine depletion 15 3.96E-8
4 SGTC_3205 9113483 4.98 49.5 µM 3.52E-7 8 3.15E-7
5 SGTC_1808 st050063 4.77 61.5 µM 1.03E-6 3 9.13E-7
6 SGTC_604 1000-0114 4.74 314.0 µM 1.18E-6 6 1.05E-6
7 SGTC_2600 tangeritin 4.64 88.0 µM 2.00E-6 18 1.77E-6
8 SGTC_2497 7-hydroxyflavone 4.62 100.0 µM 2.16E-6 11 1.90E-6
9 SGTC_1368 1852-0141 4.61 284.0 µM 2.31E-6 ERG2 25 2.04E-6
10 SGTC_557 1315-0110 4.48 16.2 µM 4.16E-6 Golgi 14 3.67E-6
11 SGTC_1145 3546-0597 4.33 10.2 µM 8.54E-6 mitochondrial processes 13 7.50E-6
12 SGTC_3118 9124250 4.20 49.5 µM 1.54E-5 9 1.34E-5
13 SGTC_1976 st070609 4.13 63.5 µM 2.03E-5 9 1.78E-5
14 SGTC_1862 st057513 3.99 3.8 µM 3.73E-5 9 3.25E-5
15 SGTC_1474 0330-0125 3.99 5.3 µM 3.81E-5 29 3.32E-5
16 SGTC_1772 st048439 3.86 82.2 µM 6.47E-5 41 5.63E-5
17 SGTC_1159 4092-0538 3.80 61.2 µM 8.32E-5 35 7.24E-5
18 SGTC_367 0335-0881 3.80 7.1 µM 8.33E-5 ubiquinone biosynthesis & proteasome 85 7.25E-5
19 SGTC_2171 5739187 3.76 198.1 µM 9.72E-5 copper-dependent oxidative stress 21 8.45E-5
20 SGTC_2508 celastrol 3.73 40.5 µM 1.11E-4 PDR1 23 9.64E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 5.39E-18 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.105 1.20E-9 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.100 7.16E-9 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.096 2.97E-8 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.091 1.24E-7 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.089 2.78E-7 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.087 4.63E-7 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.081 2.68E-6 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.079 4.93E-6 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.076 1.10E-5 YAL056W GPB2 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication
0.075 1.52E-5 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.074 1.73E-5 YGL190C CDC55 hom Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion
0.074 1.92E-5 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.072 2.66E-5 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.072 2.81E-5 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta