YNL101W / AVT4

Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL101W / AVT4

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-3.00|P-value:9.83E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:7.37|P-value:1.15E-14 ID:SGTC_144|Compound:4161-2749|FD-Score:5.12|P-value:5.60E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:7.60|P-value:1.81E-15 ID:SGTC_203|Compound:k066-0004|FD-Score:3.03|P-value:8.19E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.71|P-value:6.05E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.32|P-value:3.69E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.29|P-value:3.20E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.21|P-value:6.32E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.54|P-value:1.28E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:4.25|P-value:5.24E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.80|P-value:4.03E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.45|P-value:1.69E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.40|P-value:2.54E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.02|P-value:8.46E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.22|P-value:4.12E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.76|P-value:4.11E-7 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.63|P-value:8.38E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.13|P-value:5.71E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.26|P-value:3.57E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.02|P-value:8.54E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.22|P-value:4.16E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.81|P-value:3.82E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.59|P-value:9.65E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_2041|Compound:5107442|FD-Score:4.05|P-value:1.33E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.21|P-value:4.31E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.07|P-value:7.09E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.22|P-value:4.25E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.50|P-value:1.55E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.25|P-value:4.08E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.29|P-value:4.79E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.06|P-value:7.49E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.06|P-value:8.09E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.14|P-value:8.84E-6 ID:SGTC_2713|Compound:st079149|FD-Score:4.62|P-value:8.51E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.01|P-value:9.07E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.56|P-value:1.15E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.09|P-value:6.81E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.88|P-value:3.16E-5 ID:SGTC_2952|Compound:9073731|FD-Score:3.42|P-value:1.91E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.86|P-value:3.12E-5 ID:SGTC_3040|Compound:9091894|FD-Score:6.84|P-value:7.07E-13 ID:SGTC_3071|Compound:9117417|FD-Score:-3.37|P-value:2.59E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-4.62|P-value:9.45E-7 ID:SGTC_3137|Compound:9097352|FD-Score:4.35|P-value:3.23E-6 ID:SGTC_3204|Compound:9114183|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.37|P-value:2.92E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.00|P-value:9.83E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:7.37|P-value:1.15E-14 ID:SGTC_144|Compound:4161-2749|FD-Score:5.12|P-value:5.60E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:7.60|P-value:1.81E-15 ID:SGTC_203|Compound:k066-0004|FD-Score:3.03|P-value:8.19E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.71|P-value:6.05E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.32|P-value:3.69E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.29|P-value:3.20E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.21|P-value:6.32E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.54|P-value:1.28E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:4.25|P-value:5.24E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.80|P-value:4.03E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.45|P-value:1.69E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.40|P-value:2.54E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.02|P-value:8.46E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.22|P-value:4.12E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.76|P-value:4.11E-7 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.63|P-value:8.38E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.13|P-value:5.71E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.26|P-value:3.57E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.02|P-value:8.54E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.22|P-value:4.16E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.81|P-value:3.82E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.59|P-value:9.65E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_2041|Compound:5107442|FD-Score:4.05|P-value:1.33E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.21|P-value:4.31E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.07|P-value:7.09E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.22|P-value:4.25E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.50|P-value:1.55E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.25|P-value:4.08E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.29|P-value:4.79E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.06|P-value:7.49E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.06|P-value:8.09E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.14|P-value:8.84E-6 ID:SGTC_2713|Compound:st079149|FD-Score:4.62|P-value:8.51E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.01|P-value:9.07E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.56|P-value:1.15E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.09|P-value:6.81E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.88|P-value:3.16E-5 ID:SGTC_2952|Compound:9073731|FD-Score:3.42|P-value:1.91E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.86|P-value:3.12E-5 ID:SGTC_3040|Compound:9091894|FD-Score:6.84|P-value:7.07E-13 ID:SGTC_3071|Compound:9117417|FD-Score:-3.37|P-value:2.59E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-4.62|P-value:9.45E-7 ID:SGTC_3137|Compound:9097352|FD-Score:4.35|P-value:3.23E-6 ID:SGTC_3204|Compound:9114183|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.37|P-value:2.92E-6

Top fitness defect scores for YNL101W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 7.60 38.4 µM 1.81E-15 DNA intercalators 10 1.53E-14
2 SGTC_68 0986-0284 7.37 82.8 µM 1.15E-14 10 8.58E-14
3 SGTC_3040 9091894 6.84 49.5 µM 7.07E-13 DNA intercalators 5 4.03E-12
4 SGTC_144 4161-2749 5.12 112.4 µM 5.60E-8 DNA intercalators 9 1.53E-7
5 SGTC_1349 flufenamic acid 4.76 69.0 µM 4.11E-7 4 9.86E-7
6 SGTC_2713 st079149 4.62 53.4 µM 8.51E-7 12 1.95E-6
7 SGTC_2772 vinpocetine 4.56 57.1 µM 1.15E-6 16 2.59E-6
8 SGTC_785 1270-0111 4.54 65.3 µM 1.28E-6 15 2.84E-6
9 SGTC_1135 dihydrocapsaicin 4.40 536.7 nM 2.54E-6 23 5.41E-6
10 SGTC_3301 9125354 4.37 19.8 µM 2.92E-6 10 6.18E-6
11 SGTC_3137 9097352 4.35 49.5 µM 3.23E-6 32 6.77E-6
12 SGTC_358 0075-0058 4.32 9.4 µM 3.69E-6 50 7.67E-6
13 SGTC_799 1310-0557 4.25 151.0 µM 5.24E-6 superoxide 17 1.07E-5
14 SGTC_729 4092-0585 4.21 94.1 µM 6.32E-6 21 1.27E-5
15 SGTC_2712 st079126 4.14 47.7 µM 8.84E-6 10 1.74E-5
16 SGTC_1926 methyl fluorone black 4.10 53.6 µM 1.05E-5 DNA intercalators 55 2.05E-5
17 SGTC_2041 5107442 4.05 45.3 µM 1.33E-5 RSC complex & mRNA processing 28 2.56E-5
18 SGTC_2995 9067767 3.86 71.4 µM 3.12E-5 21 5.66E-5
19 SGTC_1825 st052143 3.81 62.6 µM 3.82E-5 17 6.84E-5
20 SGTC_975 1335-0046 3.80 28.5 µM 4.03E-5 RPP1 & pyrimidine depletion 41 7.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 5.88E-79 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.293 2.82E-67 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.251 4.15E-49 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.251 3.62E-49 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.236 9.95E-44 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.226 4.72E-40 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.222 1.34E-38 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.218 2.02E-37 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.217 3.91E-37 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.207 7.88E-34 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.207 9.37E-34 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.198 5.91E-31 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.181 4.67E-26 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.177 4.50E-25 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.169 6.45E-23 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin