YNL105W_d / RRT16

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL105W / RRT16

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:6.78|P-value:1.62E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:6.27|P-value:1.51E-13 ID:SGTC_67|Compound:0335-0847|FD-Score:10.60|P-value:1.56E-35 ID:SGTC_77|Compound:0828-0286|FD-Score:-6.10|P-value:6.05E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.68|P-value:9.05E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.13|P-value:1.36E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.14|P-value:1.27E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.60|P-value:1.40E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-2.75|P-value:6.84E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:2.74|P-value:7.19E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.68|P-value:9.38E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.12|P-value:1.43E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.33|P-value:5.33E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:2.68|P-value:9.28E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.57|P-value:1.64E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.80|P-value:5.60E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-2.76|P-value:6.36E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.80|P-value:5.63E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.55|P-value:1.85E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.74|P-value:7.17E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.47|P-value:9.91E-8 ID:SGTC_1675|Compound:st018485|FD-Score:-3.63|P-value:1.15E-5 ID:SGTC_1713|Compound:st033146|FD-Score:2.83|P-value:5.06E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.91|P-value:5.67E-9 ID:SGTC_1722|Compound:st034304|FD-Score:-4.75|P-value:1.54E-8 ID:SGTC_1848|Compound:st056003|FD-Score:-3.44|P-value:3.09E-5 ID:SGTC_1908|Compound:st060353|FD-Score:2.75|P-value:6.87E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.23|P-value:4.47E-7 ID:SGTC_2011|Compound:4012611|FD-Score:-2.66|P-value:9.86E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.69|P-value:8.66E-6 ID:SGTC_2155|Compound:5570423|FD-Score:-2.66|P-value:9.80E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.01|P-value:2.27E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-2.81|P-value:5.25E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.39|P-value:1.58E-7 ID:SGTC_2256|Compound:7954252|FD-Score:-3.09|P-value:1.59E-4 ID:SGTC_2262|Compound:9014885|FD-Score:2.84|P-value:4.78E-4 ID:SGTC_2298|Compound:7976326|FD-Score:2.73|P-value:7.47E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.67|P-value:9.30E-6 ID:SGTC_2314|Compound:7727897|FD-Score:-2.78|P-value:5.93E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.44|P-value:3.25E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:2.94|P-value:3.20E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.90|P-value:5.60E-51 ID:SGTC_2584|Compound:androsterone|FD-Score:4.90|P-value:6.08E-9 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.09|P-value:1.56E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.78|P-value:5.98E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.95|P-value:3.10E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.47|P-value:2.69E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.84|P-value:4.76E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-2.91|P-value:3.48E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.58|P-value:1.51E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.98|P-value:1.90E-6 ID:SGTC_2922|Compound:7999257|FD-Score:-3.58|P-value:1.55E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-2.68|P-value:8.95E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.27|P-value:7.07E-5 ID:SGTC_3210|Compound:9128157|FD-Score:8.31|P-value:2.00E-22 ID:SGTC_64|Compound:000l-0018|FD-Score:6.78|P-value:1.62E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:6.27|P-value:1.51E-13 ID:SGTC_67|Compound:0335-0847|FD-Score:10.60|P-value:1.56E-35 ID:SGTC_77|Compound:0828-0286|FD-Score:-6.10|P-value:6.05E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.68|P-value:9.05E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.13|P-value:1.36E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.14|P-value:1.27E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.60|P-value:1.40E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-2.75|P-value:6.84E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:2.74|P-value:7.19E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.68|P-value:9.38E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.12|P-value:1.43E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.33|P-value:5.33E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:2.68|P-value:9.28E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.57|P-value:1.64E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.80|P-value:5.60E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-2.76|P-value:6.36E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.80|P-value:5.63E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.55|P-value:1.85E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.74|P-value:7.17E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.47|P-value:9.91E-8 ID:SGTC_1675|Compound:st018485|FD-Score:-3.63|P-value:1.15E-5 ID:SGTC_1713|Compound:st033146|FD-Score:2.83|P-value:5.06E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.91|P-value:5.67E-9 ID:SGTC_1722|Compound:st034304|FD-Score:-4.75|P-value:1.54E-8 ID:SGTC_1848|Compound:st056003|FD-Score:-3.44|P-value:3.09E-5 ID:SGTC_1908|Compound:st060353|FD-Score:2.75|P-value:6.87E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.23|P-value:4.47E-7 ID:SGTC_2011|Compound:4012611|FD-Score:-2.66|P-value:9.86E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.69|P-value:8.66E-6 ID:SGTC_2155|Compound:5570423|FD-Score:-2.66|P-value:9.80E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.01|P-value:2.27E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-2.81|P-value:5.25E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.39|P-value:1.58E-7 ID:SGTC_2256|Compound:7954252|FD-Score:-3.09|P-value:1.59E-4 ID:SGTC_2262|Compound:9014885|FD-Score:2.84|P-value:4.78E-4 ID:SGTC_2298|Compound:7976326|FD-Score:2.73|P-value:7.47E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.67|P-value:9.30E-6 ID:SGTC_2314|Compound:7727897|FD-Score:-2.78|P-value:5.93E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.44|P-value:3.25E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:2.94|P-value:3.20E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.90|P-value:5.60E-51 ID:SGTC_2584|Compound:androsterone|FD-Score:4.90|P-value:6.08E-9 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.09|P-value:1.56E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.78|P-value:5.98E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.95|P-value:3.10E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.47|P-value:2.69E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.84|P-value:4.76E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-2.91|P-value:3.48E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.58|P-value:1.51E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.98|P-value:1.90E-6 ID:SGTC_2922|Compound:7999257|FD-Score:-3.58|P-value:1.55E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-2.68|P-value:8.95E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.27|P-value:7.07E-5 ID:SGTC_3210|Compound:9128157|FD-Score:8.31|P-value:2.00E-22

Top fitness defect scores for YNL105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 12.90 100.0 µM 5.60E-51 redox potentiating 31 3.32E-38
2 SGTC_67 0335-0847 10.60 266.0 µM 1.56E-35 ubiquinone biosynthesis & proteasome 18 8.96E-27
3 SGTC_3210 9128157 8.31 49.5 µM 2.00E-22 5 4.59E-17
4 SGTC_64 000l-0018 6.78 272.1 µM 1.62E-15 ubiquinone biosynthesis & proteasome 63 6.15E-12
5 SGTC_65 0798-0905 6.27 35.0 µM 1.51E-13 calcium & mitochondrial duress 26 1.79E-10
6 SGTC_1714 st033236 4.91 13.6 µM 5.67E-9 9 4.55E-7
7 SGTC_2584 androsterone 4.90 48.7 µM 6.08E-9 cell wall 84 4.79E-7
8 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 4.47 67.5 µM 9.91E-8 24 3.85E-6
9 SGTC_2009 4012297 4.23 12.1 µM 4.47E-7 cell wall signaling 54 1.19E-5
10 SGTC_2912 7964298 3.98 10.9 µM 1.90E-6 cell wall 96 3.50E-5
11 SGTC_634 1611-4317 3.57 11.2 µM 1.64E-5 ERG2 29 1.77E-4
12 SGTC_1142 3253-1408 3.55 9.8 µM 1.85E-5 21 1.93E-4
13 SGTC_2633 5,7-dihydroxyisoflavone 3.47 100.0 µM 2.69E-5 45 2.56E-4
14 SGTC_2454 5-benzylidenerhodanine 3.44 10.4 µM 3.25E-5 TRP & mitochondrial translation 65 2.95E-4
15 SGTC_2926 9010726 3.27 65.2 µM 7.07E-5 53 5.29E-4
16 SGTC_138 0850-0259 3.13 40.9 µM 1.36E-4 cell wall 265 8.67E-4
17 SGTC_360 0957-0399 3.12 1.0 µM 1.43E-4 cell wall 90 8.99E-4
18 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 2.95 100.0 µM 3.10E-4 80 0.00161
19 SGTC_2566 crystal violet carbinol 2.94 226.0 nM 3.20E-4 91 0.00165
20 SGTC_2262 9014885 2.84 67.5 µM 4.78E-4 20 0.00224

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.422 1.59E-144 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.313 3.59E-77 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.312 1.37E-76 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.297 3.25E-69 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.286 2.32E-64 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.278 1.36E-60 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.270 2.91E-57 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.269 9.46E-57 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.264 9.95E-55 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.264 1.18E-54 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.262 7.23E-54 YDL194W SNF3 hom Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication
0.257 1.01E-51 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.256 3.40E-51 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.247 6.76E-48 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.244 1.15E-46 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover