YNL107W / YAF9

Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL107W / YAF9

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.26|P-value:9.22E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:5.08|P-value:4.09E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:3.82|P-value:3.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.41|P-value:9.89E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:6.20|P-value:2.49E-8 ID:SGTC_93|Compound:0109-0045|FD-Score:4.78|P-value:1.32E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.62|P-value:7.03E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.86|P-value:3.48E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.56|P-value:8.97E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.88|P-value:3.26E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.62|P-value:7.33E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.77|P-value:1.38E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:4.76|P-value:1.46E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.34|P-value:6.94E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.56|P-value:1.48E-11 ID:SGTC_229|Compound:benomyl|FD-Score:7.95|P-value:1.34E-12 ID:SGTC_232|Compound:clozapine|FD-Score:4.27|P-value:8.99E-5 ID:SGTC_276|Compound:colchicine|FD-Score:6.22|P-value:2.33E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:3.62|P-value:7.31E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.68|P-value:6.10E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.27|P-value:8.81E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.68|P-value:6.16E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.65|P-value:2.55E-9 ID:SGTC_695|Compound:3505-6186|FD-Score:5.20|P-value:2.46E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.63|P-value:6.80E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.07|P-value:1.67E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.51|P-value:9.84E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.72|P-value:1.68E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.80|P-value:4.26E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.21|P-value:1.08E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.85|P-value:3.60E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.11|P-value:1.46E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.78|P-value:4.24E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:9.92|P-value:1.33E-18 ID:SGTC_931|Compound:2812-0076|FD-Score:4.51|P-value:3.77E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.75|P-value:5.03E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:8.40|P-value:7.73E-14 ID:SGTC_1204|Compound:4049-0315|FD-Score:6.27|P-value:1.75E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.30|P-value:7.85E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.50|P-value:3.92E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.66|P-value:2.16E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.65|P-value:8.90E-12 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.91|P-value:3.01E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.60|P-value:7.84E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.71|P-value:1.75E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.16|P-value:1.30E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.43|P-value:4.95E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.63|P-value:2.42E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.94|P-value:9.02E-8 ID:SGTC_1973|Compound:st070275|FD-Score:3.66|P-value:6.51E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.14|P-value:1.41E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.97|P-value:2.43E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.86|P-value:3.51E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.30|P-value:7.96E-5 ID:SGTC_2141|Compound:5621638|FD-Score:6.43|P-value:8.07E-9 ID:SGTC_2174|Compound:5790901|FD-Score:5.88|P-value:1.17E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.91|P-value:2.96E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.20|P-value:1.15E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.69|P-value:5.98E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.99|P-value:2.30E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.41|P-value:5.41E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.79|P-value:4.32E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.74|P-value:5.12E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.63|P-value:7.25E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.27|P-value:8.36E-5 ID:SGTC_2301|Compound:7769476|FD-Score:5.29|P-value:1.70E-6 ID:SGTC_2319|Compound:6033012|FD-Score:4.09|P-value:1.65E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.08|P-value:1.73E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.13|P-value:3.23E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.49|P-value:4.08E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:8.11E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.71|P-value:5.61E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.63|P-value:2.39E-5 ID:SGTC_2799|Compound:7812892|FD-Score:4.54|P-value:3.30E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.08|P-value:1.69E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.36|P-value:6.46E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.50|P-value:3.80E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.81|P-value:4.08E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.87|P-value:3.22E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.69|P-value:6.04E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.59|P-value:8.02E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.48|P-value:3.84E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.62|P-value:7.42E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-5.03|P-value:4.49E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.87|P-value:3.45E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.65|P-value:6.77E-4 ID:SGTC_3330|Compound:9141424|FD-Score:7.92|P-value:1.69E-12 ID:SGTC_36|Compound:0335-0881|FD-Score:4.26|P-value:9.22E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:5.08|P-value:4.09E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:3.82|P-value:3.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.41|P-value:9.89E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:6.20|P-value:2.49E-8 ID:SGTC_93|Compound:0109-0045|FD-Score:4.78|P-value:1.32E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.62|P-value:7.03E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.86|P-value:3.48E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.56|P-value:8.97E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.88|P-value:3.26E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.62|P-value:7.33E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.77|P-value:1.38E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:4.76|P-value:1.46E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.34|P-value:6.94E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.56|P-value:1.48E-11 ID:SGTC_229|Compound:benomyl|FD-Score:7.95|P-value:1.34E-12 ID:SGTC_232|Compound:clozapine|FD-Score:4.27|P-value:8.99E-5 ID:SGTC_276|Compound:colchicine|FD-Score:6.22|P-value:2.33E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:3.62|P-value:7.31E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.68|P-value:6.10E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.27|P-value:8.81E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.68|P-value:6.16E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.65|P-value:2.55E-9 ID:SGTC_695|Compound:3505-6186|FD-Score:5.20|P-value:2.46E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.63|P-value:6.80E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.07|P-value:1.67E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.51|P-value:9.84E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.72|P-value:1.68E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.80|P-value:4.26E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.21|P-value:1.08E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.85|P-value:3.60E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.11|P-value:1.46E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.78|P-value:4.24E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:9.92|P-value:1.33E-18 ID:SGTC_931|Compound:2812-0076|FD-Score:4.51|P-value:3.77E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.75|P-value:5.03E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:8.40|P-value:7.73E-14 ID:SGTC_1204|Compound:4049-0315|FD-Score:6.27|P-value:1.75E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.30|P-value:7.85E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.50|P-value:3.92E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.66|P-value:2.16E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.65|P-value:8.90E-12 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.91|P-value:3.01E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.60|P-value:7.84E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.71|P-value:1.75E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.16|P-value:1.30E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.43|P-value:4.95E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.63|P-value:2.42E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.94|P-value:9.02E-8 ID:SGTC_1973|Compound:st070275|FD-Score:3.66|P-value:6.51E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.14|P-value:1.41E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.97|P-value:2.43E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.86|P-value:3.51E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.30|P-value:7.96E-5 ID:SGTC_2141|Compound:5621638|FD-Score:6.43|P-value:8.07E-9 ID:SGTC_2174|Compound:5790901|FD-Score:5.88|P-value:1.17E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.91|P-value:2.96E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.20|P-value:1.15E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.69|P-value:5.98E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.99|P-value:2.30E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.41|P-value:5.41E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.79|P-value:4.32E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.74|P-value:5.12E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.63|P-value:7.25E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.27|P-value:8.36E-5 ID:SGTC_2301|Compound:7769476|FD-Score:5.29|P-value:1.70E-6 ID:SGTC_2319|Compound:6033012|FD-Score:4.09|P-value:1.65E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.08|P-value:1.73E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.13|P-value:3.23E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.49|P-value:4.08E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:8.11E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.71|P-value:5.61E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.63|P-value:2.39E-5 ID:SGTC_2799|Compound:7812892|FD-Score:4.54|P-value:3.30E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.08|P-value:1.69E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.36|P-value:6.46E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.50|P-value:3.80E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.81|P-value:4.08E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.87|P-value:3.22E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.69|P-value:6.04E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.59|P-value:8.02E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.48|P-value:3.84E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.62|P-value:7.42E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-5.03|P-value:4.49E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.87|P-value:3.45E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.65|P-value:6.77E-4 ID:SGTC_3330|Compound:9141424|FD-Score:7.92|P-value:1.69E-12

Top fitness defect scores for YNL107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_928 2764-0428 9.92 58.7 µM 1.33E-18 cell wall 2 1.66E-23
2 SGTC_1150 3909-7983 8.40 10.9 µM 7.73E-14 1 2.28E-17
3 SGTC_229 benomyl 7.95 22.9 µM 1.34E-12 tubulin folding & SWR complex 14 8.97E-16
4 SGTC_3330 9141424 7.92 71.4 µM 1.69E-12 amide catabolism 3 1.21E-15
5 SGTC_1374 2889-5571 7.65 141.0 µM 8.90E-12 RSC complex & mRNA processing 5 1.02E-14
6 SGTC_221 trifluoperazine 7.56 10.3 µM 1.48E-11 NEO1-PIK1 92 1.96E-14
7 SGTC_673 1082-0474 6.65 110.0 µM 2.55E-9 RSC complex & mRNA processing 20 1.48E-11
8 SGTC_2141 5621638 6.43 7.7 µM 8.07E-9 tubulin folding & SWR complex 11 6.49E-11
9 SGTC_1204 4049-0315 6.27 18.3 µM 1.75E-8 1 1.75E-10
10 SGTC_276 colchicine 6.22 750.0 µM 2.33E-8 1 2.54E-10
11 SGTC_61 0978-8327 6.20 98.6 µM 2.49E-8 ergosterol biosynthesis 6 2.76E-10
12 SGTC_1875 nocodazole 5.94 6.0 µM 9.02E-8 tubulin folding & SWR complex 31 1.44E-9
13 SGTC_2174 5790901 5.88 200.0 µM 1.17E-7 tubulin folding & SWR complex 16 2.00E-9
14 SGTC_58 0957-0393 5.41 9.0 µM 9.89E-7 cell wall 247 3.11E-8
15 SGTC_2301 7769476 5.29 200.0 µM 1.70E-6 14 6.24E-8
16 SGTC_695 3505-6186 5.20 243.0 µM 2.46E-6 8 1.00E-7
17 SGTC_2409 alverine citrate 5.13 64.0 µM 3.23E-6 31 1.41E-7
18 SGTC_38 0929-0051 5.08 58.3 µM 4.09E-6 8 1.91E-7
19 SGTC_93 0109-0045 4.78 59.2 µM 1.32E-5 DNA damage response 22 8.60E-7
20 SGTC_184 1494-0393 4.77 24.7 µM 1.38E-5 38 9.09E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.311 3.68E-76 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.306 9.07E-74 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.279 7.94E-61 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.261 2.67E-53 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.252 6.91E-50 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.249 1.29E-48 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.230 1.14E-41 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.189 1.84E-28 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.186 1.74E-27 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.174 3.18E-24 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.173 6.31E-24 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.173 7.42E-24 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.148 8.39E-18 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.143 1.17E-16 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.143 1.06E-16 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation